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Endocrinology Vol. 138, No. 10 4410-4415
Copyright © 1997 by The Endocrine Society

ARTICLES

Transgenic Mice Overexpressing the Prolactin Gene Develop Dramatic Enlargement of the Prostate Gland1

Håkan Wennbo, Jon Kindblom, Olle G. P. Isaksson and Jan Törnell

Department of Physiology, Research Centre for Endocrinology and Metabolism, Göteborg University, Medicinaregatan 1F, S-413 90 Göteborg, Sweden (H.W., J.K., J.T.) and Department of Internal Medicine, Research Centre for Endocrinology and Metabolism, Sahlgrenska Hospital, S-413 45 Göteborg, Sweden (O.G.P.I.)

Address all correspondence and requests for reprints to: Jan Törnell, Department of Physiology, Göteborg University, Medicinaregatan 1F, S-413 90 Göteborg, Sweden. E-mail: jan.tornell{at}ss.gu.se

An altered endocrine status of elderly men has been hypothesized to be important for development of prostate hyperplasia. The present study addresses the question whether increased PRL expression is of importance for development of prostate hyperplasia in mice. Three lines of PRL transgenic mice were generated having serum levels of PRL of approximately 15 ng/ml, 100 ng/ml, and 250 ng/ml, respectively. These mice developed dramatic enlargement of the prostate gland, approximately 20 times the normal prostate weight and they had a 4- to 5-fold increased DNA content. Histologically, the prostate glands in the transgenic mice were distended from secretion, and the amount of interstitial tissue was increased. The levels of testosterone and IGF-I were increased in the PRL transgenic animals. In mice overexpressing the bovine GH gene, displaying elevated IGF-1 levels, the prostate gland was slightly larger compared with normal mice, indicating that the effect of PRL was not primarily mediated through elevated plasma IGF-I levels. The present study suggests that PRL is an important factor in the development of prostate hyperplasia acting directly on the prostate gland or via increased plasma levels of testosterone.




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