help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Simoni, M. G.
Right arrow Articles by Forloni, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Simoni, M. G.
Right arrow Articles by Forloni, G. L.
Endocrinology Vol. 138, No. 12 5220-5226
Copyright © 1997 by The Endocrine Society

ARTICLES

Interferon-{gamma} Potentiates Interleukin (IL)-6 and Tumor Necrosis Factor-{alpha} But Not IL-1ß Induced by Endotoxin in the Brain

M. G. De Simoni, L. Terreni, R. Chiesa, F. Mangiarotti and G. L. Forloni

Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy

Address all correspondence and requests for reprints to: Dr. Maria Grazia De Simoni, Istituto Mario Negri, Via Eritrea 62, 20157 Milan, Italy. E-mail: de-simoni{at}irfmn.mnegri.it

Because interferon-{gamma} (IFN{gamma}) is present in the central nervous system during neurologic diseases associated with inflammation, its effect on endotoxin-induced cytokines was studied. Cerebrospinal fluid (CSF) and serum levels of interleukin (IL)-1ß, IL-6, and tumor necrosis factor-{alpha} (TNF{alpha}), their messenger RNA expression in brain areas (hypothalamus, hyppocampus, and striatum) and in spleen were evaluated 2 and 8 h after endotoxin [lipopolysaccharide (LPS), 25 µg/rat icv], IFN{gamma} (2.5 µg/rat icv) or after their coadministration in rats. CSF and serum IL-1ß levels were increased by LPS alone and IFN{gamma} coadministration did not furtherly increase them. IFN{gamma} potentiated LPS effect on IL-6 and TNF{alpha} levels in both CSF and serum. LPS and IFN-{gamma} coadministration did not alter IL-1ß messenger RNA expression induced by LPS in brain areas and in spleen, but it potentiated that of IL-6 and TNF{alpha}. The present in vivo data show that icv coadministration of LPS and IFN{gamma} results in a potentiation of cytokine production (IL-6 and TNF{alpha}) which may trigger a cascade of events relevant to neurodegenerative processes. This action is independent of IL-1ß because the production of this cytokine is not altered by IFN{gamma} treatment.




This article has been cited by other articles:


Home page
 J PsychopharmacolHome page
G. J. Paterson, Y. Ohashi, G. P. Reynolds, J. A. Pratt, and B. J. Morris
Selective increases in the cytokine, TNF{alpha}, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: influence of antipsychotic drugs
J Psychopharmacol, September 1, 2006; 20(5): 636 - 642.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. Shimizu, M. Miyoshi, K. Matsumoto, O. Goto, T. Imoto, and T. Watanabe
The Effect of Central Injection of Angiotensin-Converting Enzyme Inhibitor and the Angiotensin Type 1 Receptor Antagonist on the Induction by Lipopolysaccharide of Fever and Brain Interleukin-1{beta} Response in Rats
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 865 - 873.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
P. F Smith and C. L Darlington
Recent developments in drug therapy for multiple sclerosis
Multiple Sclerosis, April 1, 1999; 5(2): 110 - 120.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society