help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, J.
Right arrow Articles by Linzer, D. I. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, J.
Right arrow Articles by Linzer, D. I. H.
Endocrinology Vol. 138, No. 12 5541-5549
Copyright © 1997 by The Endocrine Society

ARTICLES

Three New Members of the Mouse Prolactin/Growth Hormone Family Are Homologous to Proteins Expressed in the Rat1

Jiandie Lin, Jason Poole and Daniel I. H. Linzer

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208

Address all correspondence and requests for reprints to: Dr. Daniel I. H. Linzer, Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, Illinois 60208. E-mail: dlinzer{at}nwu.edu

A search of a mouse expressed sequence tag database for novel messenger RNAs (mRNAs) in the PRL/GH family has identified three clones that are homologous to the rat PRL-like protein A (PLP-A), PRL-like protein B (PLP-B), and decidual/trophoblast PRL-related protein (d/tPRP). Full-length complementary DNA clones for each of these three mouse mRNAs have been sequenced. Mouse PLP-A is predicted to be synthesized as a precursor of 227 residues and secreted as a glycoprotein of 196 amino acids; the secreted protein shares 78% identity with rat PLP-A. The open reading frame for mouse PLP-B encodes a protein of 230 residues; the putative mature glycoprotein of 201 amino acids is 66% identical to rat PLP-B. The third mouse complementary DNA clone encodes a precursor protein of 240 residues and a secreted glycoprotein of 211 amino acids with 64% identity to rat d/tPRP. All three mouse mRNAs are expressed specifically in the placenta or decidua. The highest levels of the PLP-A mRNA are detected on day 12, at which time expression is localized to a subset of trophoblast giant cells, especially those cells that line maternal blood sinuses. PLP-B mRNA levels are high on day 10 in decidual cells and on day 12 in spongiotrophoblasts. The mRNA similar to rat d/tPRP is present at high levels even earlier in gestation (day 8) and is localized to the decidual layer. The identification of PRL-related mRNAs in common between the mouse and rat indicates that the encoded hormones are evolutionarily conserved and, therefore, likely to play important roles in reproductive physiology.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. M. K. Alam, T. Konno, N. Sahgal, L. Lu, and M. J. Soares
Decidual Cells Produce a Heparin-binding Prolactin Family Cytokine with Putative Intrauterine Regulatory Actions
J. Biol. Chem., July 4, 2008; 283(27): 18957 - 18968.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. M. K. Alam, T. Konno, G. Dai, L. Lu, D. Wang, J. H. Dunmore, A. R. Godwin, and M. J. Soares
A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor
Development, January 15, 2007; 134(2): 407 - 415.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Ain, G. Dai, J. H. Dunmore, A. R. Godwin, and M. J. Soares
From the Cover: A prolactin family paralog regulates reproductive adaptations to a physiological stressor
PNAS, November 23, 2004; 101(47): 16543 - 16548.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Ozturk, A. Fresnoza, A. Savoie, H. W. Duckworth, and M. L. Duckworth
Defining Regulatory Regions in the Rat Prolactin Gene Family Locus Using a Large P1 Genomic Clone
Endocrinology, November 1, 2003; 144(11): 4742 - 4754.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. O. Wiemers, L.-j. Shao, R. Ain, G. Dai, and M. J. Soares
The Mouse Prolactin Gene Family Locus
Endocrinology, January 1, 2003; 144(1): 313 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
S. Li and E. Goldberg
A Novel N-Terminal Domain Directs Membrane Localization of Mouse Testis-Specific Calpastatin
Biol Reprod, December 1, 2000; 63(6): 1594 - 1600.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
I.-T. Hwang, Y.-H. Lee, B.-C. Moon, K.-Y. Ahn, S.-W. Lee, and J.-Y. Chun
Identification and Characterization of a New Member of the Placental Prolactin-Like Protein-C (PLP-C) Subfamily, PLP-C{beta}
Endocrinology, September 1, 2000; 141(9): 3343 - 3352.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. J. Toft and D. I.H. Linzer
Identification of Three Prolactin-Related Hormones as Markers of Invasive Trophoblasts in the Rat
Biol Reprod, August 1, 2000; 63(2): 519 - 525.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
G. T. Ma and D. I.H. Linzer
GATA-2 Restricts Prolactin-Like Protein A Expression to Secondary Trophoblast Giant Cells in the Mouse
Biol Reprod, August 1, 2000; 63(2): 570 - 574.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. T. FASSETT, R. T. HAMILTON, and M. NILSEN-HAMILTON
Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in this Gene Family for its Expression in the Adult Mouse Tail and Ear
Endocrinology, May 1, 2000; 141(5): 1863 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Nokelainen, H. Peltoketo, M. Mustonen, and P. Vihko
Expression of Mouse 17{beta}-Hydroxysteroid Dehydrogenase/17-Ketosteroid Reductase Type 7 in the Ovary, Uterus, and Placenta: Localization from Implantation to Late Pregnancy
Endocrinology, February 1, 2000; 141(2): 772 - 778.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Toft and D. I. H. Linzer
Prolactin (PRL)-Like Protein J, a Novel Member of the PRL/Growth Hormone Family, Is Exclusively Expressed in Maternal Decidua
Endocrinology, November 1, 1999; 140(11): 5095 - 5101.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
G. Dai, M. W. Wolfe, and M. J. Soares
Distinct Regulatory Regions from the Prolactin-Like Protein C Variant Promoter Direct Trophoblast Giant Cell Versus Spongiotrophoblast Cell-Specific Expression
Endocrinology, October 1, 1999; 140(10): 4691 - 4698.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
H. Müller, B. Liu, B. A. Croy, J. R. Head, J. S. Hunt, G. Dai, and M. J. Soares
Uterine Natural Killer Cells Are Targets for a Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein A
Endocrinology, June 1, 1999; 140(6): 2711 - 2720.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
G. Dai, B. M. Chapman, B. Liu, K. E. Orwig, D. Wang, R. A. White, B. Preuett, and M. J. Soares
A New Member of the Mouse Prolactin (PRL)-Like Protein-C Subfamily, PRL-Like Protein-C{alpha}: Structure and Expression
Endocrinology, December 1, 1998; 139(12): 5157 - 5163.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Lin and D. I. H. Linzer
Identification of Trophoblast-Specific Regulatory Elements in the Mouse Placental Lactogen II Gene
Mol. Endocrinol., March 1, 1998; 12(3): 418 - 427.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. Lin, J. Poole, and D. I. H. Linzer
Two Novel Members of the Prolactin/Growth Hormone Family Are Expressed in the Mouse Placenta
Endocrinology, December 1, 1997; 138(12): 5535 - 5540.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society