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Distribution and Localization of a Novel Cholecystokinin-Releasing Factor in the Rat Gastrointestinal Tract¹

Advanced Bioscience Laboratories-Basic Research Program (N.T.), National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702; Department of Physiology (A.W.S., G.M.G.), University of Texas Health Science Center, San Antonio, Texas 78284; Department of Surgery (G.G., J.T.R., J.C.T., M.R.H., G.H.G.), The University of Texas Medical Branch, Galveston, Texas 77555; Center for Ulcer Research Education: Center for Digestive Disease Research (J.R.R.), Veterans Administration-West Los Angeles, Los Angeles, California 90073; and Department of Medicine (R.A.L.), Duke University Medical Center, Durham, North Carolina 27710

Address all correspondence and requests for reprints to: George H. Greeley, Jr., Ph.D., Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555-0725. E-mail: ggreeley{at}mspo2.med.utmb.edu

The purpose of this study was to examine the distribution and localization of an intestinal cholecystokinin (CCK)-releasing factor, called luminal CCK-releasing factor (LCRF), in the gastrointestinal tract and pancreas of the rat. RIA analysis indicates that LCRF immunoreactivity is found throughout the gut including the pancreas, stomach, duodenum, jejunum, ileum, and colon with the highest levels in the small intestine. Immunohistochemistry analysis shows LCRF immunoreactivity staining in intestinal villi, Brunner’s glands of the duodenum, the duodenal myenteric plexus, gastric pits, pancreatic ductules, and pancreatic islets. These results indicate potential sources for secretagogue-stimulated release of luminal LCRF and support the hypothesis that LCRF is secreted into the intestinal lumen to stimulate CCK release from mucosal CCK cells.

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