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Influence of Estrogenic Status on the Lipolytic Activity of Parametrial Adipose Tissue in Vivo: an in Situ Microdialysis Study¹

Centre de Biochimie (C.D., G.A., R.N.) (UMR 6543 CNRS), Université de Nice-Sophia Antipolis, Faculté des Sciences, Parc Valrose, 06108 Nice cedex 2, France; and Laboratoire THERAMEX (R.D., J.P.), Preclinical R & D Department, BP 59, MC 98000 Monaco cedex

Address all correspondence and requests for reprints to: Prof. Raymond Negrel, Centre de Biochimie (UMR 6543 CNRS), Université de Nice-Sophia Antipolis, Faculté des Sciences, Parc Valrose, 06108 Nice cedex 2, France. E-mail: Negrel{at}unice fr.

Ovarian hormones have been shown to modulate the metabolism of adipose cells obtained from adipose tissue of different animals. The aim of this study was to better understand the short- and long-term influences of estrogens on the in vivo lipolytic response of rat parametrial fat pads, determined by measurement of extracellular glycerol concentrations using in situ microdialysis. Possible direct effects of estrogens on lipolysis were studied by perfusion of a potent estrogenic analogue such as moxestrol. Moxestrol (10^-6 M) failed to increase glycerol concentrations in estrus, diestrus, or 8-day ovariectomized animals. However, the basal glycerol concentrations and the lipolytic responses stimulated by 10^-6 M isoproterenol were decreased in parametrial fat pads of diestrus, compared with estrus, rats. Greater decreases in basal and stimulated glycerol concentrations were observed in rats that had been ovariectomized for 8, 15, or 30 days. In ovariectomized rats, isoproterenol-induced lipolysis was restored to the levels observed in diestrus animals by a daily injection of 17ß-estradiol for a period of 7 days. These results implicate estrogens as long-term modulators of in vivo basal and stimulated lipolytic responses of rat parametrial fat pad.

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