| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Articles |
and ß
Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute (G.G.J.M.K., K.G., E.E., J.-Å.G.); and KaroBio AB (B.C., J.H., S.N.) Huddinge, Sweden
Address all correspondence and requests for reprints to: George Kuiper, Center for Biotechnology, Karolinska Institute, NOVUM, S-14186 Huddinge, Sweden. E-mail: george.kuiper{at}cbt.ki.se
The rat estrogen receptor (ER) exists as two subtypes, ER
and ERß,
which differ in the C-terminal ligand binding domain and in the
N-terminal transactivation domain. In this study we investigated the
messenger RNA expression of both ER subtypes in rat tissues by RT-PCR
and compared the ligand binding specificity of the ER subtypes.
Saturation ligand binding analysis of in vitro
synthesized human ER
and rat ERß protein revealed a single binding
component for 16
-iodo-17ß-estradiol with high affinity
[dissociation constant (Kd) = 0.1 nM for ER
protein and 0.4 nM for ERß protein]. Most estrogenic
substances or estrogenic antagonists compete with
16
-[125I]iodo-17ß-estradiol for binding to both ER
subtypes in a very similar preference and degree; that is,
diethylstilbestrol > hexestrol > dienestrol >
4-OH-tamoxifen > 17ß-estradiol > coumestrol,
ICI-164384 > estrone, 17
-estradiol > nafoxidine,
moxestrol > clomifene > estriol, 4-OH-estradiol >
tamoxifen, 2-OH-estradiol, 5-androstene-3ß,17ß-diol, genistein for
the ER
protein and dienestrol > 4-OH-tamoxifen >
diethylstilbestrol > hexestrol > coumestrol,
ICI-164384 > 17ß-estradiol > estrone,
genistein > estriol > nafoxidine,
5-androstene-3ß,17ß-diol > 17
-estradiol, clomifene,
2-OH-estradiol > 4-OH-estradiol, tamoxifen, moxestrol for the
ERß protein. The rat tissue distribution and/or the relative level of
ER
and ERß expression seems to be quite different,
i.e. moderate to high expression in uterus, testis,
pituitary, ovary, kidney, epididymis, and adrenal for ER
and
prostate, ovary, lung, bladder, brain, uterus, and testis for ERß.
The described differences between the ER subtypes in relative ligand
binding affinity and tissue distribution could contribute to the
selective action of ER agonists and antagonists in different tissues.
This article has been cited by other articles:
![]() |
R. Singhal, K. Shankar, T. M Badger, and M. J Ronis Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17{beta}-estradiol treatment J. Endocrinol., July 1, 2009; 202(1): 141 - 152. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Hooper, J.J. Ryder, M.S. Kurzer, J.W. Lampe, M.J. Messina, W.R. Phipps, and A. Cassidy Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis Hum. Reprod. Update, July 1, 2009; 15(4): 423 - 440. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Shao, M. Nutu, L. Karlsson-Lindahl, A. Benrick, B. Weijdegard, S. Lager, E. Egecioglu, J. Fernandez-Rodriguez, K. Gemzell-Danielsson, C. Ohlsson, et al. Downregulation of cilia-localized Il-6R{alpha} by 17{beta}-estradiol in mouse and human fallopian tubes Am J Physiol Cell Physiol, July 1, 2009; 297(1): C140 - C151. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Yang, S. Hu, J. Chen, M. A. Choudhry, L. W. Rue III, K. I. Bland, and I. H. Chaudry Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses J. Leukoc. Biol., June 1, 2009; 85(6): 1015 - 1026. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. M. Boue, S. L. Tilghman, S. Elliott, M. C. Zimmerman, K. Y. Williams, F. Payton-Stewart, A. P. Miraflor, M. H. Howell, B. Y. Shih, C. H. Carter-Wientjes, et al. Identification of the Potent Phytoestrogen Glycinol in Elicited Soybean (Glycine max) Endocrinology, May 1, 2009; 150(5): 2446 - 2453. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Messina and A. H Wu Perspectives on the soy-breast cancer relation Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1673S - 1679S. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Sonestedt, M. I. L. Ivarsson, S. Harlid, U. Ericson, B. Gullberg, J. Carlson, H. Olsson, H. Adlercreutz, and E. Wirfalt The Protective Association of High Plasma Enterolactone with Breast Cancer Is Reasonably Robust in Women with Polymorphisms in the Estrogen Receptor {alpha} and {beta} Genes J. Nutr., May 1, 2009; 139(5): 993 - 1001. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Keay and J. W. Thornton Hormone-Activated Estrogen Receptors in Annelid Invertebrates: Implications for Evolution and Endocrine Disruption Endocrinology, April 1, 2009; 150(4): 1731 - 1738. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Trukhacheva, Z. Lin, S. Reierstad, Y.-H. Cheng, M. Milad, and S. E. Bulun Estrogen Receptor (ER) {beta} Regulates ER{alpha} Expression in Stromal Cells Derived from Ovarian Endometriosis J. Clin. Endocrinol. Metab., February 1, 2009; 94(2): 615 - 622. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Ajdzanovic, B. Sosic-Jurjevic, B. Filipovic, S. Trifunovic, M. Manojlovic-Stojanoski, M. Sekulic, and V. Milosevic Genistein-Induced Histomorphometric and Hormone Secreting Changes in the Adrenal Cortex in Middle-Aged Rats Experimental Biology and Medicine, February 1, 2009; 234(2): 148 - 156. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Su and R. C.M. Simmen Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates {beta}-catenin signaling in mammary epithelial cells Carcinogenesis, February 1, 2009; 30(2): 331 - 339. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Sato, T. Suzuki, Y. Katayose, K. Miura, K. Shiiba, H. Tateno, Y. Miki, J. Akahira, Y. Kamogawa, S. Nagasaki, et al. Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma: Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors Cancer Res., February 1, 2009; 69(3): 914 - 922. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. S. Driscoll and J. M. Grant-Kels Estrogen Receptor Expression in Cutaneous Melanoma Arch Dermatol, January 1, 2009; 145(1): 73 - 75. [Full Text] [PDF] |
||||
![]() |
M. Chen, I. Hsu, A. Wolfe, S. Radovick, K. Huang, S. Yu, C. Chang, E. M. Messing, and S. Yeh Defects of Prostate Development and Reproductive System in the Estrogen Receptor-{alpha} Null Male Mice Endocrinology, January 1, 2009; 150(1): 251 - 259. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Weiss, M. L. Bernhardt, M. M. Laronda, L. A. Hurley, C. Glidewell-Kenney, S. Pillai, M. Tong, K. S. Korach, and J. L. Jameson Estrogen Actions in the Male Reproductive System Involve Estrogen Response Element-Independent Pathways Endocrinology, December 1, 2008; 149(12): 6198 - 6206. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Weiss, J. V. Lacey Jr., X.-O. Shu, B.-T. Ji, L. Hou, G. Yang, H. Li, N. Rothman, A. Blair, Y.-T. Gao, et al. Menstrual and Reproductive Factors in Association With Lung Cancer in Female Lifetime Nonsmokers Am. J. Epidemiol., December 1, 2008; 168(11): 1319 - 1325. [Abstract] [Full Text] [PDF] |
||||
![]() |
L Lundholm, G Bryzgalova, H Gao, N Portwood, S Falt, K D Berndt, A Dicker, D Galuska, J R Zierath, J-A Gustafsson, et al. The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms J. Endocrinol., November 1, 2008; 199(2): 275 - 286. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Jiang, N. M. Patterson, Y. Ling, J. Xie, W. G. Helferich, and D. J. Shapiro Low Concentrations of the Soy Phytoestrogen Genistein Induce Proteinase Inhibitor 9 and Block Killing of Breast Cancer Cells by Immune Cells Endocrinology, November 1, 2008; 149(11): 5366 - 5373. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. S. Shirke, S. R. Jadhav, and A. G. Jagtap Methanolic Extract of Cuminum cyminum Inhibits Ovariectomy-Induced Bone Loss in Rats Experimental Biology and Medicine, November 1, 2008; 233(11): 1403 - 1410. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. F. Ba and I. H. Chaudry Role of estrogen receptor subtypes in estrogen-induced organ-specific vasorelaxation after trauma-hemorrhage Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H2061 - H2067. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. A. Molenda-Figueira, S. D. Murphy, K. L. Shea, N. K. Siegal, Y. Zhao, J. G. Chadwick Jr., L. A. Denner, and M. J. Tetel Steroid Receptor Coactivator-1 from Brain Physically Interacts Differentially with Steroid Receptor Subtypes Endocrinology, October 1, 2008; 149(10): 5272 - 5279. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. R. Bhavnani, S.-P. Tam, and X. Lu Structure Activity Relationships and Differential Interactions and Functional Activity of Various Equine Estrogens Mediated via Estrogen Receptors (ERs) ER{alpha} and ER{beta} Endocrinology, October 1, 2008; 149(10): 4857 - 4870. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.-M. Suzuki, Y. Isohama, H. Maruyama, Y. Yamada, Y. Narita, S. Ohta, Y. Araki, T. Miyata, and S. Mishima Estrogenic Activities of Fatty Acids and a Sterol Isolated from Royal Jelly Evid. Based Complement. Altern. Med., September 1, 2008; 5(3): 295 - 302. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Ikeda, H. Tanaka, and M. Esaki Effects of Gestational Diethylstilbestrol Treatment on Male and Female Gonads during Early Embryonic Development Endocrinology, August 1, 2008; 149(8): 3970 - 3979. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Raju and I. H. Chaudry Sex Steroids/Receptor Antagonist: Their Use as Adjuncts After Trauma-Hemorrhage for Improving Immune/Cardiovascular Responses and for Decreasing Mortality from Subsequent Sepsis Anesth. Analg., July 1, 2008; 107(1): 159 - 166. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-Y. Deng, P.-S. Hsieh, J.-P. Huang, L.-S. Lu, and L.-M. Hung Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways Diabetes, July 1, 2008; 57(7): 1814 - 1823. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. de Cremoux, D. Rosenberg, J. Goussard, C. Bremont-Weil, F. Tissier, C. Tran-Perennou, L. Groussin, X. Bertagna, J. Bertherat, and M.-L. Raffin-Sanson Expression of progesterone and estradiol receptors in normal adrenal cortex, adrenocortical tumors, and primary pigmented nodular adrenocortical disease Endocr. Relat. Cancer, June 1, 2008; 15(2): 465 - 474. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Hammoud, B. Tan, S. Badve, and R. M Bigsby Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma Endocr. Relat. Cancer, June 1, 2008; 15(2): 475 - 483. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wahlgren, K. Svechnikov, M.-L. Strand, K. Jahnukainen, M. Parvinen, J.-A. Gustafsson, and O. Soder Estrogen Receptor {beta} Selective Ligand 5{alpha}-Androstane-3{beta}, 17{beta}-Diol Stimulates Spermatogonial Deoxyribonucleic Acid Synthesis in Rat Seminiferous Epithelium in Vitro Endocrinology, June 1, 2008; 149(6): 2917 - 2922. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. K. Nayak, H. J. Hathaway, C. Ramesh, J. B. Arterburn, D. Dai, L. A. Sklar, J. P. Norenberg, and E. R. Prossnitz Preclinical Development of a Neutral, Estrogen Receptor-Targeted, Tridentate 99mTc(I)-Estradiol-Pyridin-2-yl Hydrazine Derivative for Imaging of Breast and Endometrial Cancers J. Nucl. Med., June 1, 2008; 49(6): 978 - 986. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Asai, T. Tokunaga, K. Kondo, T. Kawaguchi, S. Takayanagi, T. Shinmyozu, M. Nakai, Y. Yakabe, and Y. Shimohigashi Direct Measure of Fluorescence Intensity for Efficient Receptor-binding Assay: Conjugates of Ethinylcarboxyestradiol and 5(and 6)-Carboxyfluorescein via {alpha},{omega}-Diaminoalkanes as a Tracer for Estrogen Receptor J. Biochem., June 1, 2008; 143(6): 781 - 792. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. C. Chang, T. H. Charn, S.-H. Park, W. G. Helferich, B. Komm, J. A. Katzenellenbogen, and B. S. Katzenellenbogen Estrogen Receptors {alpha} and {beta} as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding Mol. Endocrinol., May 1, 2008; 22(5): 1032 - 1043. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Rasbach and R. G. Schnellmann Isoflavones Promote Mitochondrial Biogenesis J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 536 - 543. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Grossini, C. Molinari, D. A. S. G. Mary, F. Uberti, P. P. Caimmi, N. Surico, and G. Vacca Intracoronary Genistein Acutely Increases Coronary Blood Flow in Anesthetized Pigs through {beta}-Adrenergic Mediated Nitric Oxide Release and Estrogenic Receptors Endocrinology, May 1, 2008; 149(5): 2678 - 2687. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. R. Cederroth, M. Vinciguerra, A. Gjinovci, F. Kuhne, M. Klein, M. Cederroth, D. Caille, M. Suter, D. Neumann, R. W. James, et al. Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism Diabetes, May 1, 2008; 57(5): 1176 - 1185. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Dip, S. Lenz, J.-P. Antignac, B. Le Bizec, H. Gmuender, and H. Naegeli Global gene expression profiles induced by phytoestrogens in human breast cancer cells Endocr. Relat. Cancer, March 1, 2008; 15(1): 161 - 173. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Mattingly, M. M. Ivanova, K. A. Riggs, N. S. Wickramasinghe, M. J. Barch, and C. M. Klinge Estradiol Stimulates Transcription of Nuclear Respiratory Factor-1 and Increases Mitochondrial Biogenesis Mol. Endocrinol., March 1, 2008; 22(3): 609 - 622. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Sperry and J. P. Minei Gender dimorphism following injury: making the connection from bench to bedside J. Leukoc. Biol., March 1, 2008; 83(3): 499 - 506. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.A. Walters, C.M. Allan, and D.J. Handelsman Androgen Actions and the Ovary Biol Reprod, March 1, 2008; 78(3): 380 - 389. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Buteau-Lozano, G. Velasco, M. Cristofari, P. Balaguer, and M. Perrot-Applanat Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism J. Endocrinol., February 1, 2008; 196(2): 399 - 412. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Mardon, J. Mathey, S. Kati-Coulibaly, C. Puel, M.-J. Davicco, P. Lebecque, M.-N. Horcajada, and V. Coxam Influence of Lifelong Soy Isoflavones Consumption on Bone Mass in the Rat Experimental Biology and Medicine, February 1, 2008; 233(2): 229 - 237. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Levy, D. Tatomer, C. B. Herber, X. Zhao, H. Tang, T. Sargeant, L. J. Ball, J. Summers, T. P. Speed, and D. C. Leitman Differential Regulation of Native Estrogen Receptor-Regulatory Elements by Estradiol, Tamoxifen, and Raloxifene Mol. Endocrinol., February 1, 2008; 22(2): 287 - 303. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. D. DuSell, M. Umetani, P. W. Shaul, D. J. Mangelsdorf, and D. P. McDonnell 27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator Mol. Endocrinol., January 1, 2008; 22(1): 65 - 77. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. E. Damdimopoulos, G. Spyrou, and J.-A. Gustafsson Ligands Differentially Modify the Nuclear Mobility of Estrogen Receptors {alpha} and Endocrinology, January 1, 2008; 149(1): 339 - 345. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Cvoro, D. Tatomer, M.-K. Tee, T. Zogovic, H. A. Harris, and D. C. Leitman Selective Estrogen Receptor- Agonists Repress Transcription of Proinflammatory Genes J. Immunol., January 1, 2008; 180(1): 630 - 636. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. G. Schwartz, A. S. Wenzlaff, G. M. Prysak, V. Murphy, M. L. Cote, S. C. Brooks, D. F. Skafar, and F. Lonardo Reproductive Factors, Hormone Use, Estrogen Receptor Expression and Risk of Non Small-Cell Lung Cancer in Women J. Clin. Oncol., December 20, 2007; 25(36): 5785 - 5792. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. B Alabraba, P. Taniere, G. M Reynolds, P. M Stewart, S. J Wigmore, and S. R Bramhall Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas Endocr. Relat. Cancer, December 1, 2007; 14(4): 1081 - 1088. [Abstract] [Full Text] [PDF] |
||||
![]() |
P.-A. Scott, A. Tremblay, M. Brochu, and J. St-Louis Vasorelaxant action of 17 -estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3713 - H3719. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Sun, Z. Nawaz, and J. M. Slingerland Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells Mol. Endocrinol., November 1, 2007; 21(11): 2651 - 2662. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. M. Cho, N. Peng, J. T. Clark, L. Novak, S. Roysommuti, J. Prasain, and J. M. Wyss Genistein Attenuates the Hypertensive Effects of Dietary NaCl in Hypertensive Male Rats Endocrinology, November 1, 2007; 148(11): 5396 - 5402. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-C. Chen, P. Kraft, P. Bretsky, S. Ketkar, D. J. Hunter, D. Albanes, D. Altshuler, G. Andriole, C. D. Berg, H. Boeing, et al. Sequence Variants of Estrogen Receptor {beta} and Risk of Prostate Cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 1973 - 1981. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Tammemagi, M. T. Freedman, T. R. Church, M. M. Oken, W. G. Hocking, P. A. Kvale, P. Hu, T. L. Riley, L. R. Ragard, P. C. Prorok, et al. Factors Associated with Human Small Aggressive Non Small Cell Lung Cancer Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2082 - 2089. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A Pearl, E. At-Taras, T. Berger, and J. F Roser Reduced endogenous estrogen delays epididymal development but has no effect on efferent duct morphology in boars Reproduction, October 1, 2007; 134(4): 593 - 604. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Wang, E. R. Prossnitz, and S. K. Roy Expression of G Protein-Coupled Receptor 30 in the Hamster Ovary: Differential Regulation by Gonadotropins and Steroid Hormones Endocrinology, October 1, 2007; 148(10): 4853 - 4864. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Xue, Z. Lin, Y.-H. Cheng, C.-C. Huang, E. Marsh, P. Yin, M. P Milad, E. Confino, S. Reierstad, J. Innes, et al. Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis Biol Reprod, October 1, 2007; 77(4): 681 - 687. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. A. Ansari and J. Gandy Determining the Transrepression Activity of Xenoestrogen on Nuclear Factor-{kappa}B in Cos-1 Cells by Estrogen Receptor-{alpha} International Journal of Toxicology, September 1, 2007; 26(5): 441 - 449. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Duffy, K. Perez, and A. Partridge Implications of Phytoestrogen Intake for Breast Cancer CA Cancer J Clin, September 1, 2007; 57(5): 260 - 277. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. T. Akingbemi, T. D. Braden, B. W. Kemppainen, K. D. Hancock, J. D. Sherrill, S. J. Cook, X. He, and J. G. Supko Exposure to Phytoestrogens in the Perinatal Period Affects Androgen Secretion by Testicular Leydig Cells in the Adult Rat Endocrinology, September 1, 2007; 148(9): 4475 - 4488. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Suzuki, T. Shimizu, H.-P. Yu, Y.-C. Hsieh, M. A. Choudhry, K. I. Bland, and I. H. Chaudry Estrogen receptor-{alpha} predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage Am J Physiol Cell Physiol, September 1, 2007; 293(3): C978 - C984. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. A Grippo, K. Capps, B. Rougeau, and B. J Gurley Analysis of Flavonoid Phytoestrogens in Botanical and Ephedra-Containing Dietary Supplements Ann. Pharmacother., September 1, 2007; 41(9): 1375 - 1382. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. E. Drummond, M. Tellbach, M. Dyson, and J. K. Findlay Fibroblast Growth Factor-9, a Local Regulator of Ovarian Function Endocrinology, August 1, 2007; 148(8): 3711 - 3721. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. H. Dang, T. H. Nguyen, K.-C. Choi, and E.-B. Jeung A Calcium-Binding Protein, Calbindin-D9k, Is Regulated through an Estrogen-Receptor Mediated Mechanism following Xenoestrogen Exposure in the GH3 Cell Line Toxicol. Sci., August 1, 2007; 98(2): 408 - 415. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Arreguin-Arevalo, T. L. Davis, and T. M. Nett Differential Modulation of Gonadotropin Secretion by Selective Estrogen Receptor 1 and Estrogen Receptor 2 Agonists in Ovariectomized Ewes Biol Reprod, August 1, 2007; 77(2): 320 - 328. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. E. Mann, D. J. Rowlands, F. Y.L. Li, P. de Winter, and R. C.M. Siow Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression Cardiovasc Res, July 15, 2007; 75(2): 261 - 274. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Strom, E. Treuter, M. Warner, et al. Estrogen Receptors: How Do They Signal and What Are Their Targets Physiol Rev, July 1, 2007; 87(3): 905 - 931. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. R. Pak, W. C. J. Chung, L. R. Hinds, and R. J. Handa Estrogen Receptor-{beta} Mediates Dihydrotestosterone-Induced Stimulation of the Arginine Vasopressin Promoter in Neuronal Cells Endocrinology, July 1, 2007; 148(7): 3371 - 3382. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Suzuki, T. Shimizu, H.-P. Yu, Y.-C. Hsieh, M. A. Choudhry, and I. H. Chaudry Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-{alpha} Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2103 - C2111. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Li, M. E Andersen, S. Heber, and Q. Zhang Non-monotonic dose-response relationship in steroid hormone receptor-mediated gene expression J. Mol. Endocrinol., May 1, 2007; 38(5): 569 - 585. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Kipp, S. M. Kilen, S. Bristol-Gould, T. K. Woodruff, and K. E. Mayo Neonatal Exposure to Estrogens Suppresses Activin Expression and Signaling in the Mouse Ovary Endocrinology, May 1, 2007; 148(5): 1968 - 1976. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C Garrido-Gracia, A. Gordon, C. Bellido, R. Aguilar, I. Barranco, Y. Millan, J. M. de las Mulas, and J. E Sanchez-Criado The integrated action of oestrogen receptor isoforms and sites with progesterone receptor in the gonadotrope modulates LH secretion: evidence from tamoxifen-treated ovariectomized rats J. Endocrinol., April 1, 2007; 193(1): 107 - 119. [Abstract] [Full Text] [PDF] |
||||
![]() |
G.-E. Costin and V. J. Hearing Human skin pigmentation: melanocytes modulate skin color in response to stress FASEB J, April 1, 2007; 21(4): 976 - 994. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-C. Hsieh, H.-P. Yu, M. Frink, T. Suzuki, M. A. Choudhry, M. G. Schwacha, and I. H. Chaudry G Protein-Coupled Receptor 30-Dependent Protein Kinase A Pathway Is Critical in Nongenomic Effects of Estrogen in Attenuating Liver Injury after Trauma-Hemorrhage Am. J. Pathol., April 1, 2007; 170(4): 1210 - 1218. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Gruvberger-Saal, P.-O. Bendahl, L. H. Saal, M. Laakso, C. Hegardt, P. Eden, C. Peterson, P. Malmstrom, J. Isola, A. Borg, et al. Estrogen Receptor {beta} Expression Is Associated with Tamoxifen Response in ER{alpha}-Negative Breast Carcinoma Clin. Cancer Res., April 1, 2007; 13(7): 1987 - 1994. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Corbacho, J. P. Eiserich, L. A. Zuniga, G. Valacchi, and A. C. Villablanca Compromised Aortic Vasoreactivity in Male Estrogen Receptor-{alpha}-Deficient Mice during Acute Lipopolysaccharide-Induced Inflammation Endocrinology, March 1, 2007; 148(3): 1403 - 1411. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. L. Quinn, J. M. Regan, J. M. Tobin, B. J. Marinik, J. M. McMahon, D. A. McNett, C. M. Sushynski, S. D. Crofoot, P. A. Jean, and K. P. Plotzke In Vitro and In Vivo Evaluation of the Estrogenic, Androgenic, and Progestagenic Potential of Two Cyclic Siloxanes Toxicol. Sci., March 1, 2007; 96(1): 145 - 153. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Moroni, G. Pisoni, G. Savoini, E. van Lier, S. Acuna, J. P. Damian, and A. Meikle Influence of Estrus of Dairy Goats on Somatic Cell Count, Milk Traits, and Sex Steroid Receptors in the Mammary Gland J Dairy Sci, February 1, 2007; 90(2): 790 - 797. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. A. Carey, J. W. Card, J. A. Bradbury, M. P. Moorman, N. Haykal-Coates, S. H. Gavett, J. P. Graves, V. R. Walker, G. P. Flake, J. W. Voltz, et al. Spontaneous Airway Hyperresponsiveness in Estrogen Receptor-{alpha}-deficient Mice Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 126 - 135. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. A. Harris Estrogen Receptor-{beta}: Recent Lessons from in Vivo Studies Mol. Endocrinol., January 1, 2007; 21(1): 1 - 13. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Huang, F. Shi, T. Lei, Y. Song, C. L. Hughes, and G. Liu Effect of the Isoflavone Genistein Against Galactose-Induced Cataracts in Rats Experimental Biology and Medicine, January 1, 2007; 232(1): 118 - 125. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Assinder, R. Davis, M. Fenwick, and A. Glover Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells Reproduction, January 1, 2007; 133(1): 11 - 19. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Suzuki, T. Shimizu, H.-P. Yu, Y.-C. Hsieh, M. A. Choudhry, M. G. Schwacha, and I. H. Chaudry Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage J Appl Physiol, January 1, 2007; 102(1): 163 - 168. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. F. Ba, A. Lu, T. Shimizu, L. Szalay, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry 17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H245 - H250. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Fan, M. Warner, and J.-A. Gustafsson Estrogen receptor beta expression in the embryonic brain regulates development of calretinin-immunoreactive GABAergic interneurons PNAS, December 19, 2006; 103(51): 19338 - 19343. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Rice and S. A Whitehead Phytoestrogens and breast cancer -promoters or protectors? Endocr. Relat. Cancer, December 1, 2006; 13(4): 995 - 1015. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. J. Teede, D. Giannopoulos, F. S. Dalais, J. Hodgson, and B. P. McGrath Randomised, Controlled, Cross-Over Trial of Soy Protein with Isoflavones on Blood Pressure and Arterial Function in Hypertensive Subjects J. Am. Coll. Nutr., December 1, 2006; 25(6): 533 - 540. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Dahlman-Wright, V. Cavailles, S. A. Fuqua, V. C. Jordan, J. A. Katzenellenbogen, K. S. Korach, A. Maggi, M. Muramatsu, M. G. Parker, and J.-A. Gustafsson International Union of Pharmacology. LXIV. Estrogen Receptors Pharmacol. Rev., December 1, 2006; 58(4): 773 - 781. [Full Text] [PDF] |
||||
![]() |
K. W. Wilhelms, C. G. Scanes, and L. L. Anderson Lack of estrogenic or antiestrogenic actions of soy isoflavones in an avian model: the Japanese quail. Poult. Sci., November 1, 2006; 85(11): 1885 - 1889. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Lindzey, F. L Jayes, M. M Yates, J. F Couse, and K. S Korach The bi-modal effects of estradiol on gonadotropin synthesis and secretion in female mice are dependent on estrogen receptor-{alpha}. J. Endocrinol., October 1, 2006; 191(1): 309 - 317. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Delbes, C. Levacher, and R. Habert Estrogen effects on fetal and neonatal testicular development. Reproduction, October 1, 2006; 132(4): 527 - 538. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Messina, W. McCaskill-Stevens, and J. W. Lampe Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J Natl Cancer Inst, September 20, 2006; 98(18): 1275 - 1284. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. T. Zhu, G.-Z. Han, J.-Y. Shim, Y. Wen, and X.-R. Jiang Quantitative Structure-Activity Relationship of Various Endogenous Estrogen Metabolites for Human Estrogen Receptor {alpha} and {beta} Subtypes: Insights into the Structural Determinants Favoring a Differential Subtype Binding Endocrinology, September 1, 2006; 147(9): 4132 - 4150. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. A. Madureira, R. Varshochi, D. Constantinidou, R. E. Francis, R. C. Coombes, K.-M. Yao, and E. W.-F. Lam The Forkhead Box M1 Protein Regulates the Transcription of the Estrogen Receptor {alpha} in Breast Cancer Cells J. Biol. Chem., September 1, 2006; 281(35): 25167 - 25176. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Nickerson, S. L. Kennedy, J. D. Johnson, and M. Fleshner Sexual dimorphism of the intracellular heat shock protein 72 response J Appl Physiol, August 1, 2006; 101(2): 566 - 575. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. F. Kritzer Regional, Laminar and Cellular Distribution of Immunoreactivity for ER{beta} in the Cerebral Cortex of Hormonally Intact, Postnatally Developing Male and Female Rats Cereb Cortex, August 1, 2006; 16(8): 1181 - 1192. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. A. Babiker, D. Lips, R. Meyer, E. Delvaux, P. Zandberg, B. Janssen, G. van Eys, C. Grohe, and P. A. Doevendans Estrogen Receptor {beta} Protects the Murine Heart Against Left Ventricular Hypertrophy Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1524 - 1530. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. W. Hsieh, S. S. Rajan, S. K. Sharma, Y. Guo, E. R. DeSombre, M. Mrksich, and G. L. Greene Identification of Ligands with Bicyclic Scaffolds Provides Insights into Mechanisms of Estrogen Receptor Subtype Selectivity J. Biol. Chem., June 30, 2006; 281(26): 17909 - 17919. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. B. J. Morales, K. K. Loo, H.-b. Liu, C. Peterson, S. Tiwari-Woodruff, and R. R. Voskuhl Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. J. Neurosci., June 21, 2006; 26(25): 6823 - 6833. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |