help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gettys, T. W.
Right arrow Articles by Taylor, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gettys, T. W.
Right arrow Articles by Taylor, I. L.
Endocrinology Vol. 138, No. 7 2697-2704
Copyright © 1997 by The Endocrine Society

ARTICLES

Adrenalectomy after Weaning Restores ß3-Adrenergic Receptor Expression in White Adipocytes from C57BL/6J-ob/ob Mice1

Thomas W. Gettys, Patricia M. Watson2, Lucy Seger, Mark Padgett and Ian L. Taylor

Departments of Medicine (T.W.G., P.M.W., L.S., M.P., I.L.T.) and Biochemistry and Molecular Biology (T.W.G.), Medical University of South Carolina, Charleston, South Carolina 29425

Address all correspondence and requests for reprints to: Dr. Thomas W. Gettys, 655 Thurmond Research Building, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425. E-mail: Gettystw{at}musc.edu

The role of hypercorticism in the development of compromised ß-adrenergic signaling in adipose tissue was assessed in ob/ob mice adrenalectomized at 4 weeks of age and studied 1 and 3 weeks thereafter. Adrenalectomy prevented the rapid increase in body weight and fat deposition between 4 and 5 weeks of age in ob/ob mice and produced a phenotype indistinguishable from that of lean mice. However, adrenalectomized ob/ob mice became intermediate between lean and ob/ob mice by 7 weeks of age. Adipocyte ß3-adrenergic receptor (AR) messenger RNA levels were similar between lean and adrenalectomized ob/ob mice at both time points and were 4- to 8-fold higher than messenger RNA levels in ob/ob mice. As judged by maximal activation of adenylyl cyclase by a ß3-AR-selective agonist, adrenalectomy also restored functional activity of the ß3-AR to levels above or equivalent to those seen in lean mice at both time points. The present results suggest that development of hypercorticism at or before weaning in ob/ob mice represses expression of the ß3-AR and prevents the normal postweaning development of this signaling system in the adipocyte.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. R. Lenard, V. Prpic, A. W. Adamson, R. C. Rogers, and T. W. Gettys
Differential coupling of beta3A- and beta3B-adrenergic receptors to endogenous and chimeric G{alpha}s and G{alpha}i
Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E704 - E715.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y. Zhang, G. E Kilroy, T. M. Henagan, V. Prpic-Uhing, W. G. Richards, A. W. Bannon, R. L. Mynatt, and T. W. Gettys
Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin
FASEB J, September 1, 2005; 19(11): 1482 - 1491.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. R. Bowers, T. W. Gettys, V. Prpic, R. B. S. Harris, and T. J. Bartness
Short photoperiod exposure increases adipocyte sensitivity to noradrenergic stimulation in Siberian hamsters
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1354 - R1360.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K.-H. Jeong, S. Sakihara, E. P. Widmaier, and J. A. Majzoub
Impaired Leptin Expression and Abnormal Response to Fasting in Corticotropin-Releasing Hormone-Deficient Mice
Endocrinology, July 1, 2004; 145(7): 3174 - 3181.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Prpic, P. M. Watson, I. C. Frampton, M. A. Sabol, G. E. Jezek, and T. W. Gettys
Differential Mechanisms and Development of Leptin Resistance in A/J Versus C57BL/6J Mice during Diet-Induced Obesity
Endocrinology, April 1, 2003; 144(4): 1155 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. Prpic, P. M. Watson, I. C. Frampton, M. A. Sabol, G. E. Jezek, and T. W. Gettys
Adaptive Changes in Adipocyte Gene Expression Differ in AKR/J and SWR/J Mice during Diet-Induced Obesity
J. Nutr., November 1, 2002; 132(11): 3325 - 3332.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. M. Watson, S. P. Commins, R. J. Beiler, H. C. Hatcher, and T. W. Gettys
Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity
Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E356 - E365.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. P. Commins, P. M. Watson, M. A. Padgett, A. Dudley, G. Argyropoulos, and T. W. Gettys
Induction of Uncoupling Protein Expression in Brown and White Adipose Tissue by Leptin
Endocrinology, January 1, 1999; 140(1): 292 - 300.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. P. Commins, P. M. Watson, N. Levin, R. J. Beiler, and T. W. Gettys
Central Leptin Regulates the UCP1 and ob Genes in Brown and White Adipose Tissue via Different beta -Adrenoceptor Subtypes
J. Biol. Chem., October 13, 2000; 275(42): 33059 - 33067.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society