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Endocrinology Vol. 138, No. 7 2697-2704
Copyright © 1997 by The Endocrine Society

ARTICLES

Adrenalectomy after Weaning Restores ß3-Adrenergic Receptor Expression in White Adipocytes from C57BL/6J-ob/ob Mice1

Thomas W. Gettys, Patricia M. Watson2, Lucy Seger, Mark Padgett and Ian L. Taylor

Departments of Medicine (T.W.G., P.M.W., L.S., M.P., I.L.T.) and Biochemistry and Molecular Biology (T.W.G.), Medical University of South Carolina, Charleston, South Carolina 29425

Address all correspondence and requests for reprints to: Dr. Thomas W. Gettys, 655 Thurmond Research Building, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425. E-mail: Gettystw{at}musc.edu

The role of hypercorticism in the development of compromised ß-adrenergic signaling in adipose tissue was assessed in ob/ob mice adrenalectomized at 4 weeks of age and studied 1 and 3 weeks thereafter. Adrenalectomy prevented the rapid increase in body weight and fat deposition between 4 and 5 weeks of age in ob/ob mice and produced a phenotype indistinguishable from that of lean mice. However, adrenalectomized ob/ob mice became intermediate between lean and ob/ob mice by 7 weeks of age. Adipocyte ß3-adrenergic receptor (AR) messenger RNA levels were similar between lean and adrenalectomized ob/ob mice at both time points and were 4- to 8-fold higher than messenger RNA levels in ob/ob mice. As judged by maximal activation of adenylyl cyclase by a ß3-AR-selective agonist, adrenalectomy also restored functional activity of the ß3-AR to levels above or equivalent to those seen in lean mice at both time points. The present results suggest that development of hypercorticism at or before weaning in ob/ob mice represses expression of the ß3-AR and prevents the normal postweaning development of this signaling system in the adipocyte.




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Copyright © 1997 by The Endocrine Society