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Endocrinology Vol. 138, No. 8 3369-3373
Copyright © 1997 by The Endocrine Society

ARTICLES

Aldosterone Biosynthesis in the Rat Brain1

Celso E. Gomez-Sanchez, Ming Yi Zhou, Eduardo N. Cozza2, Hiroyuki Morita, Mark F. Foecking and Elise P. Gomez-Sanchez

Endocrinology Section (C.E.G.-S., M.F.F., E.P.G.-S.), Medical Service and Research Service, Harry S. Truman Memorial Veterans Hospital, and Department of Internal Medicine (C.E.G.-S., M.Y.Z., H.M., E.P.G.-S.), and Department of Veterinary Biomedical Sciences (E.P.G.-S.), University of Missouri-Columbia, Columbia, Missouri 65201; and Facultad de Ciencias Exactas y Naturales (E.N.C.), Universidad de Buenos Aires, 1428 Buenos Aires, Argentina

Address all correspondence and requests for reprints to: Elise P. Gomez-Sanchez, D.V.M., Ph.D., Research Service, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri 65201. E-mail: intmdceg{at}showme.missouri.edu

Messenger RNA (mRNA) for enzymes involved in adrenal steroid biosynthesis are expressed in the brain, and the coded enzymes have been shown to be active. The expression of mRNA for the cytochrome P-450 enzyme aldosterone synthase, crucial for the final step in the synthesis of aldosterone and the synthesis of aldosterone was studied in several anatomic areas of the rat brain. Expression of the mRNA for the aldosterone synthase was demonstrated by RT-PCR/Southern blot in adrenal, aorta, hypothalamus, hippocampus, amygdala, cerebrum, and cerebellum. Incubation of brain minces from intact and adrenalectomized rats demonstrated the synthesis of corticosterone and aldosterone from endogenous precursors. Incubations of brain minces with [1,23H]-deoxycorticosterone, followed by extraction and three different successive TLCs, demonstrated the presence of labeled aldosterone, corticosterone, and 18-hydroxy-deoxycorticosterone. Incubation, in the presence of 10 µM cortisol or metyrapone, inhibited the synthesis of aldosterone or both aldosterone and corticosterone, respectively. These studies indicate that the rat brain has the enzymatic machinery for the synthesis of adrenal corticosteroids and is capable of synthesizing aldosterone. Aldosterone synthesized in the brain might play a paracrine role in the regulation of blood pressure.




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