help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lalli, E.
Right arrow Articles by Sassone-Corsi, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lalli, E.
Right arrow Articles by Sassone-Corsi, P.
Endocrinology Vol. 139, No. 10 4237-4243
Copyright © 1998 by The Endocrine Society

ARTICLES

DAX-1 Blocks Steroid Production at Multiple Levels1

Enzo Lalli2, Michael H. Melner, Douglas M. Stocco and Paolo Sassone-Corsi

Institut de Génétique et de Biologie Moléculaire et Cellulaire (E.L., P.S.-C.), Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, 67404 Illkirch, Strasbourg, France; Department of Obstetrics and Gynecology (M.H.M.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2515; Department of Cell Biology & Biochemistry (D.M.S.), Texas Tech University Health Sciences Center, Lubbock, Texas 79430

Address all correspondence and requests for reprints to: Dr. Paolo Sassone-Corsi, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, Boîte Postale 163, 67404 Illkirch, Strasbourg, France. E-mail: paolosc{at}igbmc u-strasbg.fr.

DAX-1 is an unusual member of the nuclear hormone receptor superfamily whose expression is mainly, but not uniquely, restricted to steroidogenic tissues. We have recently shown that DAX-1 can block the first and rate-limiting step in steroid biosynthesis by repressing StAR (steroidogenic acute regulatory protein) expression. Here we show that DAX-1 blocks steroid production at multiple levels in the Y-1 mouse adrenocortical tumor cell line. Expression of DAX-1 in Y-1 cells significantly impairs both basal and cAMP-stimulated steroid production, without affecting the functionality of the cAMP-responsive PKA pathway. Experiments using an hydroxylated cholesterol derivative show that biochemical steps in steroidogenesis subsequent to cholesterol delivery to mitochondria are also impaired in Y-1 cells expressing DAX-1. This is explained by the repression of P450scc and 3ß-HSD expression, in addition to StAR. DAX-1 expression in Y-1 cells results in the inhibition of the activity of the StAR, P450scc and 3ß-HSD promoters. An inappropriate steroidogenic block in the male fetus might have an important role in the pathogenesis of sex reversal syndromes caused by a duplication of the genomic region of the X chromosome containing the DAX-1 gene.




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
H. A. LaVoie and S. R. King
Transcriptional Regulation of Steroidogenic Genes: STARD1, CYP11A1 and HSD3B
Experimental Biology and Medicine, August 1, 2009; 234(8): 880 - 907.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Ehrlund, E. H. Anthonisen, N. Gustafsson, N. Venteclef, K. Robertson Remen, A. E. Damdimopoulos, A. Galeeva, M. Pelto-Huikko, E. Lalli, K. R. Steffensen, et al.
E3 Ubiquitin Ligase RNF31 Cooperates with DAX-1 in Transcriptional Repression of Steroidogenesis
Mol. Cell. Biol., April 15, 2009; 29(8): 2230 - 2242.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Xu, W.-H. Yang, I. Gerin, C.-D. Hu, G. D. Hammer, and R. J. Koenig
Dax-1 and Steroid Receptor RNA Activator (SRA) Function as Transcriptional Coactivators for Steroidogenic Factor 1 in Steroidogenesis
Mol. Cell. Biol., April 1, 2009; 29(7): 1719 - 1734.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Ye, Y. Nakamura, E. Lalli, and W. E. Rainey
Differential Effects of High and Low Steroidogenic Factor-1 Expression on CYP11B2 Expression and Aldosterone Production in Adrenocortical Cells
Endocrinology, March 1, 2009; 150(3): 1303 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. Bielinska, H. Parviainen, S. Kiiveri, M. Heikinheimo, and D. B. Wilson
REVIEW PAPER: Origin and Molecular Pathology of Adrenocortical Neoplasms
Vet. Pathol., March 1, 2009; 46(2): 194 - 210.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. R. Manna, M. T. Dyson, Y. Jo, and D. M. Stocco
Role of Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene 1 in Protein Kinase A- and Protein Kinase C-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action
Endocrinology, January 1, 2009; 150(1): 187 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G.-C. Wu, S. Tomy, and C.-F. Chang
The Expression of nr0b1 and nr5a4 During Gonad Development and Sex Change in Protandrous Black Porgy Fish, Acanthopagrus schlegeli
Biol Reprod, February 1, 2008; 78(2): 200 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G.-S. Hwang, S.-W. Wang, W.-M. Tseng, C.-H. Yu, and P. S. Wang
Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1763 - E1769.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
P. R Manna, Y. Jo, and D. M Stocco
Regulation of Leydig cell steroidogenesis by extracellular signal-regulated kinase 1/2: role of protein kinase A and protein kinase C signaling
J. Endocrinol., April 1, 2007; 193(1): 53 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. M. Gummow, J. O. Scheys, V. R. Cancelli, and G. D. Hammer
Reciprocal Regulation of a Glucocorticoid Receptor-Steroidogenic Factor-1 Transcription Complex on the Dax-1 Promoter by Glucocorticoids and Adrenocorticotropic Hormone in the Adrenal Cortex
Mol. Endocrinol., November 1, 2006; 20(11): 2711 - 2723.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
A. J Casal, V. J P Sinclair, A. M Capponi, J. Nicod, U. Huynh-Do, and P. Ferrari
A novel mutation in the steroidogenic acute regulatory protein gene promoter leading to reduced promoter activity.
J. Mol. Endocrinol., August 1, 2006; 37(1): 71 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
P. R. Manna, S. P. Chandrala, S. R. King, Y. Jo, R. Counis, I. T. Huhtaniemi, and D. M. Stocco
Molecular Mechanisms of Insulin-like Growth Factor-I Mediated Regulation of the Steroidogenic Acute Regulatory Protein in Mouse Leydig Cells
Mol. Endocrinol., February 1, 2006; 20(2): 362 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. A. Myers, K. Hyatt, M. Mlynarczyk, I. M. Bird, and C. A. Ducsay
Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1707 - R1714.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M.-C. Battista, M. Otis, M. Cote, A. Laforest, M. Peter, E. Lalli, and N. Gallo-Payet
Extracellular Matrix and Hormones Modulate DAX-1 Localization in the Human Fetal Adrenal Gland
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5426 - 5431.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
F.-Q. Yu, C.-S. Han, W. Yang, X. Jin, Z.-Y. Hu, and Y.-X. Liu
Activation of the p38 MAPK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially
J. Endocrinol., July 1, 2005; 186(1): 85 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Simard, M.-L. Ricketts, S. Gingras, P. Soucy, F. A. Feltus, and M. H. Melner
Molecular Biology of the 3{beta}-Hydroxysteroid Dehydrogenase/{Delta}5-{Delta}4 Isomerase Gene Family
Endocr. Rev., June 1, 2005; 26(4): 525 - 582.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Park, J. J. Meeks, G. Raverot, L. E. Pfaff, J. Weiss, G. D. Hammer, and J. L. Jameson
Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
Development, May 15, 2005; 132(10): 2415 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
O. Zwermann, F. Beuschlein, E. Lalli, A. Klink, P. Sassone-Corsi, and M. Reincke
Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression
Eur. J. Endocrinol., May 1, 2005; 152(5): 769 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Kim, J. C. Havelock, B. R. Carr, and G. R. Attia
The Orphan Nuclear Receptor, Liver Receptor Homolog-1, Regulates Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Granulosa Cells
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1678 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Jo and D. M. Stocco
Regulation of Steroidogenesis and Steroidogenic Acute Regulatory Protein in R2C Cells by DAX-1 (Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene-1)
Endocrinology, December 1, 2004; 145(12): 5629 - 5637.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. D. Pisarska, J. Bae, C. Klein, and A. J. W. Hsueh
Forkhead L2 Is Expressed in the Ovary and Represses the Promoter Activity of the Steroidogenic Acute Regulatory Gene
Endocrinology, July 1, 2004; 145(7): 3424 - 3433.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Kim, N. Peng, W. E. Rainey, B. R. Carr, and G. R. Attia
Liver Receptor Homolog-1 Regulates the Expression of Steroidogenic Acute Regulatory Protein in Human Granulosa Cells
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 3042 - 3047.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Hossain, C. Li, and G. F. Saunders
Generation of Two Distinct Functional Isoforms of Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita-Critical Region on the X Chromosome Gene 1 (DAX-1) by Alternative Splicing
Mol. Endocrinol., June 1, 2004; 18(6): 1428 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Peng, J. W. Kim, W. E. Rainey, B. R. Carr, and G. R. Attia
The Role of the Orphan Nuclear Receptor, Liver Receptor Homologue-1, in the Regulation of Human Corpus Luteum 3{beta}-Hydroxysteroid Dehydrogenase Type II
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 6020 - 6028.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Lalli and P. Sassone-Corsi
DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual Differentiation
Mol. Endocrinol., August 1, 2003; 17(8): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Sato, T. Suzuki, K. Hidaka, H. Sato, K. Ito, S. Ito, and H. Sasano
Immunolocalization of Nuclear Transcription Factors, DAX-1 and COUP-TF II, in the Normal Human Ovary: Correlation with Adrenal 4 Binding Protein/ Steroidogenic Factor-1 Immunolocalization during the Menstrual Cycle
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3415 - 3420.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. G. Lehmann, J.-M. Wurtz, J.-P. Renaud, P. Sassone-Corsi, and E. Lalli
Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients
Hum. Mol. Genet., May 1, 2003; 12(9): 1063 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Tajima, A. Dantes, Z. Yao, K. Sorokina, F. Kotsuji, R. Seger, and A. Amsterdam
Down-Regulation of Steroidogenic Response to Gonadotropins in Human and Rat Preovulatory Granulosa Cells Involves Mitogen-Activated Protein Kinase Activation and Modulation of DAX-1 and Steroidogenic Factor-1
J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2288 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yazawa, T. Mizutani, K. Yamada, H. Kawata, T. Sekiguchi, M. Yoshino, T. Kajitani, Z. Shou, and K. Miyamoto
Involvement of Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein, Steroidogenic Factor 1, and Dax-1 in the Regulation of Gonadotropin-Inducible Ovarian Transcription Factor 1 Gene Expression by Follicle-Stimulating Hormone in Ovarian Granulosa Cells
Endocrinology, May 1, 2003; 144(5): 1920 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Osman, C. Murigande, A. Nadakal, and A. M. Capponi
Repression of DAX-1 and Induction of SF-1 Expression. TWO MECHANISMS CONTRIBUTING TO THE ACTIVATION OF ALDOSTERONE BIOSYNTHESIS IN ADRENAL GLOMERULOSA CELLS
J. Biol. Chem., October 18, 2002; 277(43): 41259 - 41267.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. Gurates, S. Sebastian, S. Yang, J. Zhou, M. Tamura, Z. Fang, T. Suzuki, H. Sasano, and S. E. Bulun
WT1 and DAX-1 Inhibit Aromatase P450 Expression in Human Endometrial and Endometriotic Stromal Cells
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4369 - 4377.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. I. Dmitrieva and P. A. Doris
Cardiotonic Steroids: Potential Endogenous Sodium Pump Ligands with Diverse Function
Experimental Biology and Medicine, September 1, 2002; 227(8): 561 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. G. Lehmann, E. Lalli, and P. Sassone-Corsi
From the Cover: X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein
PNAS, June 11, 2002; 99(12): 8225 - 8230.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, W. Shea-Eaton, M. D. Sanchez, and M. P. McLean
DAX-1 Represses the High-Density Lipoprotein Receptor Through Interaction with Positive Regulators Sterol Regulatory Element-Binding Protein-1a and Steroidogenic Factor-1
Endocrinology, December 1, 2001; 142(12): 5097 - 5106.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Domenice, A. C. Latronico, V. N. Brito, I. J. P. Arnhold, F. Kok, and B. B. Mendonca
Adrenocorticotropin-Dependent Precocious Puberty of Testicular Origin in a Boy with X-Linked Adrenal Hypoplasia Congenita Due to a Novel Mutation in the DAX1 Gene
J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4068 - 4071.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. D. Murphy, E. Lalli, L. P. Walsh, Z. Liu, J. Soh, D. M. Stocco, and P. Sassone-Corsi
Heat Shock Interferes with Steroidogenesis by Reducing Transcription of the Steroidogenic Acute Regulatory Protein Gene
Mol. Endocrinol., August 1, 2001; 15(8): 1255 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
X.-z. Lin, H. Takemori, Y. Katoh, J. Doi, N. Horike, A. Makino, Y. Nonaka, and M. Okamoto
Salt-Inducible Kinase Is Involved in the ACTH/cAMP-Dependent Protein Kinase Signaling in Y1 Mouse Adrenocortical Tumor Cells
Mol. Endocrinol., August 1, 2001; 15(8): 1264 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Sugawara, S. Abe, N. Sakuragi, Y. Fujimoto, E. Nomura, K. Fujieda, M. Saito, and S. Fujimoto
RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1
Endocrinology, August 1, 2001; 142(8): 3570 - 3577.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. L. Johnson and J. T. Bridgham
Regulation of Steroidogenic Acute Regulatory Protein and Luteinizing Hormone Receptor Messenger Ribonucleic Acid in Hen Granulosa Cells
Endocrinology, July 1, 2001; 142(7): 3116 - 3124.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. J. Wang, B. Jeffs, M. Ito, J. C. Achermann, R. N. Yu, D. B. Hales, and J. L. Jameson
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1
PNAS, June 20, 2001; (2001) 141543298.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. M. Calvo, M. Asunción, D. Tellería, J. Sancho, J. L. San Millán, and H. F. Escobar-Morreale
Screening for Mutations in the Steroidogenic Acute Regulatory Protein and Steroidogenic Factor-1 Genes, and in CYP11A and Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Gene on the X Chromosome, Gene-1 (DAX-1), in Hyperandrogenic Hirsute Women
J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1746 - 1749.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
N. A. Hanley, W. E. Rainey, D. I. Wilson, S. G. Ball, and K. L. Parker
Expression Profiles of SF-1, DAX1, and CYP17 in the Human Fetal Adrenal Gland: Potential Interactions in Gene Regulation
Mol. Endocrinol., January 1, 2001; 15(1): 57 - 68.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
C. Aigueperse, P. Val, C. Pacot, C. Darne, E. Lalli, P. Sassone-Corsi, G. Veyssiere, C. Jean, and A. Martinez
SF-1 (Steroidogenic Factor-1), C/EBP{beta} (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells
Mol. Endocrinol., January 1, 2001; 15(1): 93 - 111.
[Abstract] [Full Text]

Home page
 HypertensionHome page
R. I. Dmitrieva, A. Y. Bagrov, E. Lalli, P. Sassone-Corsi, D. M. Stocco, and P. A. Doris
Mammalian Bufadienolide Is Synthesized From Cholesterol in the Adrenal Cortex by a Pathway That Is Independent of Cholesterol Side-Chain Cleavage
Hypertension, September 1, 2000; 36(3): 442 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. Lalli, K. Ohe, C. Hindelang, and P. Sassone-Corsi
Orphan Receptor DAX-1 Is a Shuttling RNA Binding Protein Associated with Polyribosomes via mRNA
Mol. Cell. Biol., July 1, 2000; 20(13): 4910 - 4921.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
P. R. Manna, P. Pakarinen, T. El-Hefnawy, and I. T. Huhtaniemi
Functional Assessment of the Calcium Messenger System in Cultured Mouse Leydig Tumor Cells: Regulation of Human Chorionic Gonadotropin-Induced Expression of the Steroidogenic Acute Regulatory Protein
Endocrinology, April 1, 1999; 140(4): 1739 - 1751.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Zhang, J. S. Thomsen, L. Johansson, J.-A. Gustafsson, and E. Treuter
DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors
J. Biol. Chem., December 15, 2000; 275(51): 39855 - 39859.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Seger, T. Hanoch, R. Rosenberg, A. Dantes, W. E. Merz, J. F. Strauss III, and A. Amsterdam
The ERK Signaling Cascade Inhibits Gonadotropin-stimulated Steroidogenesis
J. Biol. Chem., April 20, 2001; 276(17): 13957 - 13964.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. J. Wang, B. Jeffs, M. Ito, J. C. Achermann, R. N. Yu, D. B. Hales, and J. L. Jameson
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1
PNAS, July 3, 2001; 98(14): 7988 - 7993.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society