| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ARTICLES |
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School (Y.C.L., A.E.P., J.M., M.B.D.), Boston, Massachusetts 02114; the Department of Cell Biology, Yale University School of Medicine (M.A., R.B.), New Haven, Connecticut 06510; and the Department of Bone Pathology, Hamburg University School of Medicine (M.A., M.P., G.D.), 20246 Hamburg, Germany
Address all correspondence and requests for reprints to: Marie B. Demay, M.D., Endocrine Unit, Massachusetts General Hospital, Wellman 501, 32 Fruit Street, Boston, Massachusetts 02114. E-mail: demay{at}helix.mgh.harvard.edu
1,25-Dihydroxyvitamin D3 plays a major role in intestinal calcium transport. To determine what phenotypic abnormalities observed in vitamin D receptor (VDR)-ablated mice are secondary to impaired intestinal calcium absorption rather than receptor deficiency, mineral ion levels were normalized by dietary means. VDR-ablated mice and control littermates were fed a diet that has been shown to prevent secondary hyperparathyroidism in vitamin D-deficient rats. This diet normalized growth and random serum ionized calcium levels in the VDR-ablated mice. The correction of ionized calcium levels prevented the development of parathyroid hyperplasia and the increases in PTH messenger RNA synthesis and in serum PTH levels. VDR-ablated animals fed this diet did not develop rickets or osteomalacia. However, alopecia was still observed in the VDR-ablated mice with normal mineral ions, suggesting that the VDR is required for normal hair growth. This study demonstrates that normalization of mineral ion homeostasis can prevent the development of hyperparathyroidism, osteomalacia, and rickets in the absence of the genomic actions of 1,25-dihydroxyvitamin D3.
This article has been cited by other articles:
 |
|
 |
|
  B. S. Benn, D. Ajibade, A. Porta, P. Dhawan, M. Hediger, J.-B. Peng, Y. Jiang, G. T. Oh, E.-B. Jeung, L. Lieben, et al. Active Intestinal Calcium Transport in the Absence of Transient Receptor Potential Vanilloid Type 6 and Calbindin-D9k Endocrinology, June 1, 2008; 149(6): 3196 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. McCann and B. N. Ames Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J, April 1, 2008; 22(4): 982 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. X. Tishkoff, K. A. Nibbelink, K. H. Holmberg, L. Dandu, and R. U. Simpson Functional Vitamin D Receptor (VDR) in the T-Tubules of Cardiac Myocytes: VDR Knockout Cardiomyocyte Contractility Endocrinology, February 1, 2008; 149(2): 558 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. K. Gipson The Ocular Surface: The Challenge to Enable and Protect Vision: The Friedenwald Lecture Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4391 - 4398. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Drueke, D. Martin, and M. Rodriguez Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1828 - 1839. [Full Text] [PDF]
|
|
|
|
 |
|
 T. I. Ellison, R. L. Eckert, and P. N. MacDonald Evidence for 1,25-Dihydroxyvitamin D3-independent Transactivation by the Vitamin D Receptor: UNCOUPLING THE RECEPTOR AND LIGAND IN KERATINOCYTES J. Biol. Chem., April 13, 2007; 282(15): 10953 - 10962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Demay, Y. Sabbagh, and T. O. Carpenter Calcium and Vitamin D: What Is Known About the Effects on Growing Bone Pediatrics, March 1, 2007; 119(Supplement_2): S141 - S144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xie, S. Chang, Y. Oda, and D. D. Bikle Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology, January 1, 2006; 147(1): 314 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Bula, J. Huhtakangas, C. Olivera, J. E. Bishop, A. W. Norman, and H. L. Henry Presence of a Truncated Form of the Vitamin D Receptor (VDR) in a Strain of VDR-Knockout Mice Endocrinology, December 1, 2005; 146(12): 5581 - 5586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rodriguez, C. Tu, Z. Cheng, T.-H. Chen, D. Bikle, D. Shoback, and W. Chang Expression and Functional Assessment of an Alternatively Spliced Extracellular Ca2+-Sensing Receptor in Growth Plate Chondrocytes Endocrinology, December 1, 2005; 146(12): 5294 - 5303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rodriguez, Z. Cheng, T.-H. Chen, C. Tu, and W. Chang Extracellular Calcium and Parathyroid Hormone-Related Peptide Signaling Modulate the Pace of Growth Plate Chondrocyte Differentiation Endocrinology, November 1, 2005; 146(11): 4597 - 4608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shimada, Y. Yamazaki, M. Takahashi, H. Hasegawa, I. Urakawa, T. Oshima, K. Ono, M. Kakitani, K. Tomizuka, T. Fujita, et al. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1088 - F1095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kallay, G. Bises, E. Bajna, C. Bieglmayer, W. Gerdenitsch, I. Steffan, S. Kato, H.J. Armbrecht, and H. S. Cross Colon-specific regulation of vitamin D hydroxylases--a possible approach for tumor prevention Carcinogenesis, September 1, 2005; 26(9): 1581 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sabbagh, T. O. Carpenter, and M. B. Demay Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes PNAS, July 5, 2005; 102(27): 9637 - 9642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Dusso, A. J. Brown, and E. Slatopolsky Vitamin D Am J Physiol Renal Physiol, July 1, 2005; 289(1): F8 - F28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Kovacs, M. L. Woodland, N. J. Fudge, and J. K. Friel The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E133 - E144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Skorija, M. Cox, J. M. Sisk, D. R. Dowd, P. N. MacDonald, C. C. Thompson, and M. B. Demay Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Mol. Endocrinol., April 1, 2005; 19(4): 855 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Healy, J. L. Vanhooke, J. M. Prahl, and H. F. DeLuca Parathyroid hormone decreases renal vitamin D receptor expression in vivo PNAS, March 29, 2005; 102(13): 4724 - 4728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Capuano, T. Radanovic, C. A. Wagner, D. Bacic, S. Kato, Y. Uchiyama, R. St.-Arnoud, H. Murer, and J. Biber Intestinal and renal adaptation to a low-Pi diet of type II NaPi cotransporters in vitamin D receptor- and 1{alpha}OHase-deficient mice Am J Physiol Cell Physiol, February 1, 2005; 288(2): C429 - C434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakagawa, A. Kawaura, S. Kato, E. Takeda, and T. Okano 1{alpha},25-Dihydroxyvitamin D3 is a preventive factor in the metastasis of lung cancer Carcinogenesis, February 1, 2005; 26(2): 429 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Chen and D. Lohnes Dominant-negative Retinoic Acid Receptors Elicit Epidermal Defects through a Non-canonical Pathway J. Biol. Chem., January 28, 2005; 280(4): 3012 - 3021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zheng, Y. Xie, G. Li, J. Kong, J. Q. Feng, and Y. C. Li Critical Role of Calbindin-D28k in Calcium Homeostasis Revealed by Mice Lacking Both Vitamin D Receptor and Calbindin-D28k J. Biol. Chem., December 10, 2004; 279(50): 52406 - 52413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Zinser and J. Welsh Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice Carcinogenesis, December 1, 2004; 25(12): 2361 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. G. Bolt, W. Liu, G. Qiao, J. Kong, W. Zheng, T. Krausz, G. Cs-Szabo, M. D. Sitrin, and Y. C. Li Critical role of vitamin D in sulfate homeostasis: regulation of the sodium-sulfate cotransporter by 1,25-dihydroxyvitamin D3 Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E744 - E749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Zinser and J. Welsh Accelerated Mammary Gland Development during Pregnancy and Delayed Postlactational Involution in Vitamin D3 Receptor Null Mice Mol. Endocrinol., September 1, 2004; 18(9): 2208 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Aihara, H. Azuma, M. Akaike, Y. Ikeda, M. Yamashita, T. Sudo, H. Hayashi, Y. Yamada, F. Endoh, M. Fujimura, et al. Disruption of Nuclear Vitamin D Receptor Gene Causes Enhanced Thrombogenicity in Mice J. Biol. Chem., August 20, 2004; 279(34): 35798 - 35802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Chen and W. G. Goodman Role of the calcium-sensing receptor in parathyroid gland physiology Am J Physiol Renal Physiol, June 1, 2004; 286(6): F1005 - F1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Panda, D. Miao, I. Bolivar, J. Li, R. Huo, G. N. Hendy, and D. Goltzman Inactivation of the 25-Hydroxyvitamin D 1{alpha}-Hydroxylase and Vitamin D Receptor Demonstrates Independent and Interdependent Effects of Calcium and Vitamin D on Skeletal and Mineral Homeostasis J. Biol. Chem., April 16, 2004; 279(16): 16754 - 16766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Demay Muscle: A Nontraditional 1,25-Dihydroxyvitamin D Target Tissue Exhibiting Classic Hormone-Dependent Vitamin D Receptor Actions Endocrinology, December 1, 2003; 144(12): 5135 - 5137. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zlotogorski, Z.'e. Hochberg, P. Mirmirani, A. Metzker, D. Ben-Amitai, A. Martinez-Mir, A. A. Panteleyev, and A. M. Christiano Clinical and Pathologic Correlations in Genetically Distinct Forms of Atrichia Arch Dermatol, December 1, 2003; 139(12): 1591 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Welsh, J. A. Wietzke, G. M. Zinser, B. Byrne, K. Smith, and C. J. Narvaez Vitamin D-3 Receptor as a Target for Breast Cancer Prevention J. Nutr., July 1, 2003; 133(7): 2425S - 2433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. M. Sutton and P. N. MacDonald Vitamin D: More Than a "Bone-a-Fide" Hormone Mol. Endocrinol., May 1, 2003; 17(5): 777 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. D. Quarles, D. J. Sherrard, S. Adler, S. J. Rosansky, L. C. McCary, W. Liu, S. A. Turner, and D. A. Bushinsky The Calcimimetic AMG 073 as a Potential Treatment for Secondary Hyperparathyroidism of End-Stage Renal Disease J. Am. Soc. Nephrol., March 1, 2003; 14(3): 575 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Goodman Medical management of secondary hyperparathyroidism in chronic renal failure Nephrol. Dial. Transplant., March 1, 2003; 18(90003): iii2 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Song, S. Kato, and J. C. Fleet Vitamin D Receptor (VDR) Knockout Mice Reveal VDR-Independent Regulation of Intestinal Calcium Absorption and ECaC2 and Calbindin D9k mRNA J. Nutr., February 1, 2003; 133(2): 374 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Zinser, J. P. Sundberg, and J. Welsh Vitamin D3 receptor ablation sensitizes skin to chemically induced tumorigenesis Carcinogenesis, December 1, 2002; 23(12): 2103 - 2109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vegesna, J. O'Kelly, M. Uskokovic, J. Said, N. Lemp, T. Saitoh, T. Ikezoe, L. Binderup, and H. P. Koeffler Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice Endocrinology, November 1, 2002; 143(11): 4389 - 4396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. McCormick Passive Diffusion Does Not Play a Major Role in the Absorption of Dietary Calcium in Normal Adults J. Nutr., November 1, 2002; 132(11): 3428 - 3430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Shevde, L. A. Plum, M. Clagett-Dame, H. Yamamoto, J. W. Pike, and H. F. DeLuca A potent analog of 1alpha ,25-dihydroxyvitamin D3 selectively induces bone formation PNAS, October 15, 2002; 99(21): 13487 - 13491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Silver, R. Kilav, and T. Naveh-Many Mechanisms of secondary hyperparathyroidism Am J Physiol Renal Physiol, September 1, 2002; 283(3): F367 - F376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lewin, B. Garfia, F. L. Recio, M. Rodriguez, and K. Olgaard Persistent Downregulation of Calcium-Sensing Receptor mRNA in Rat Parathyroids when Severe Secondary Hyperparathyroidism Is Reversed by an Isogenic Kidney Transplantation J. Am. Soc. Nephrol., August 1, 2002; 13(8): 2110 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Erben, D. W. Soegiarto, K. Weber, U. Zeitz, M. Lieberherr, R. Gniadecki, G. Moller, J. Adamski, and R. Balling Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Mol. Endocrinol., July 1, 2002; 16(7): 1524 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Goodman Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention Nephrol. Dial. Transplant., February 1, 2002; 17(2): 204 - 207. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zinser, K. Packman, and J. Welsh Vitamin D3 receptor ablation alters mammary gland morphogenesis Development, January 7, 2002; 129(13): 3067 - 3076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yagishita, Y. Yamamoto, T. Yoshizawa, K. Sekine, Y. Uematsu, H. Murayama, Y. Nagai, W. Krezel, P. Chambon, T. Matsumoto, et al. Aberrant Growth Plate Development in VDR/RXR{gamma} Double Null Mutant Mice Endocrinology, December 1, 2001; 142(12): 5332 - 5341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Van Cromphaut, M. Dewerchin, J. G. J. Hoenderop, I. Stockmans, E. Van Herck, S. Kato, R. J. M. Bindels, D. Collen, P. Carmeliet, R. Bouillon, et al. Duodenal calcium absorption in vitamin D receptor-knockout mice: Functional and molecular aspects PNAS, October 25, 2001; (2001) 231474698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Garner, M. Pi, Q. Tu, and L. D. Quarles Rickets in Cation-Sensing Receptor-Deficient Mice: An Unexpected Skeletal Phenotype Endocrinology, September 1, 2001; 142(9): 3996 - 4005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kallay, P. Pietschmann, S. Toyokuni, E. Bajna, P. Hahn, K. Mazzucco, C. Bieglmayer, S. Kato, and H. S. Cross Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage Carcinogenesis, September 1, 2001; 22(9): 1429 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Li, M. J. G. Bolt, L.-P. Cao, and M. D. Sitrin Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E558 - E564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Panda, D. Miao, M. L. Tremblay, J. Sirois, R. Farookhi, G. N. Hendy, and D. Goltzman Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction PNAS, June 19, 2001; 98(13): 7498 - 7503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Li, H Chiba, X Warot, N Messaddeq, C Gerard, P Chambon, and D Metzger RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations Development, January 3, 2001; 128(5): 675 - 688. [Abstract] [PDF]
|
|
|
|
 |
|
 S. J. Marx Hyperparathyroid and Hypoparathyroid Disorders N. Engl. J. Med., December 21, 2000; 343(25): 1863 - 1875. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Deplewski and R. L. Rosenfield Role of Hormones in Pilosebaceous Unit Development Endocr. Rev., August 1, 2000; 21(4): 363 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. St-Arnaud, A. Arabian, R. Travers, F. Barletta, M. Raval-Pandya, K. Chapin, J. Depovere, C. Mathieu, S. Christakos, M. B. Demay, et al. Deficient Mineralization of Intramembranous Bone in Vitamin D-24-Hydroxylase-Ablated Mice Is Due to Elevated 1,25-Dihydroxyvitamin D and Not to the Absence of 24,25-Dihydroxyvitamin D Endocrinology, July 1, 2000; 141(7): 2658 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sakai and M. B. Demay Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice Endocrinology, June 1, 2000; 141(6): 2043 - 2049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Carling, J. Rastad, E. Szabó, G. Westin, and G. Åkerström Reduced Parathyroid Vitamin D Receptor Messenger Ribonucleic Acid Levels in Primary and Secondary Hyperparathyroidism J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 2000 - 2003. [Abstract] [Full Text]
|
|
|
|
|
|
N. J. Schroeder and J. Cunningham What's new in vitamin D for the nephrologist? Nephrol. Dial. Transplant., April 1, 2000; 15(4): 460 - 466. [Full Text] [PDF]
|
|
|
|
|
|
M. Lorentzon, R. Lorentzon, and P. Nordström Vitamin D Receptor Gene Polymorphism Is Associated with Birth Height, Growth to Adolescence, and Adult Stature in Healthy Caucasian Men: A Cross-Sectional and Longitudinal Study J. Clin. Endocrinol. Metab., April 1, 2000; 85(4): 1666 - 1671. [Abstract] [Full Text]
|
|
|
|
|
|
K. Kinuta, H. Tanaka, T. Moriwake, K. Aya, S. Kato, and Y. Seino Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads Endocrinology, April 1, 2000; 141(4): 1317 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Karsenty The genetic transformation of bone biology Genes & Dev., December 1, 1999; 13(23): 3037 - 3051. [Full Text]
|
|
|
|
|
|
M. Amling, M. Priemel, T. Holzmann, K. Chapin, J. M. Rueger, R. Baron, and M. B. Demay Rescue of the Skeletal Phenotype of Vitamin D Receptor-Ablated Mice in the Setting of Normal Mineral Ion Homeostasis: Formal Histomorphometric and Biomechanical Analyses Endocrinology, November 1, 1999; 140(11): 4982 - 4987. [Abstract] [Full Text]
|
|
|
|
< |
