help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dai, G.
Right arrow Articles by Soares, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dai, G.
Right arrow Articles by Soares, M. J.
Endocrinology Vol. 139, No. 12 5157-5163
Copyright © 1998 by The Endocrine Society

ARTICLES

A New Member of the Mouse Prolactin (PRL)-Like Protein-C Subfamily, PRL-Like Protein-C{alpha}: Structure and Expression1

Guoli Dai, Belinda M. Chapman, Bing Liu, Kyle E. Orwig2, Danhua Wang3, Robert A. White, Barry Preuett and Michael J. Soares

Department of Molecular & Integrative Physiology (G.D., B.M.C., B.L., K.E.O., D.W., M.J.S.), University of Kansas Medical Center, Kansas City, Kansas 66160; Section of Medical Genetics and Molecular Medicine (R.A.W., B.P.), Children’s Mercy Hospital, Kansas City, Missouri 64108

Address all correspondence and requests for reprints to: Michael J. Soares, Ph.D., Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160-7401. E-mail: msoares{at}kumc.edu

In this study, we establish the presence of a unique member of the PRL-like protein-C (PLP-C) subfamily in the mouse, PLP-C{alpha}, characterize its complementary DNA and gene, and map its chromosomal location and pattern of expression during pregnancy. Mouse PLP-C{alpha} encodes for a 239 amino acid protein and possesses from 69–71% identity with rat PLP-C, PLP-Cv, PLP-D, and PLP-H. Another feature characteristic of PLP-C subfamily members that is also present in mouse PLP-C{alpha} is a 6-exon/5-intron gene structure including an aromatic domain encoded by exon 3. Southern analysis with mouse and rat PLP-C subfamily probes suggested the existence of a single mouse PLP-C{alpha} gene. Mouse PLP-C{alpha} maps to chromosome 13 along with other members of the mouse PRL family. Expression of mouse PLP-C{alpha} increases dramatically as gestation advances and is restricted to spongiotrophoblast and trophoblast giant cells of the junctional zone. In summary, we have established the presence of a new PLP-C subfamily member in the mouse and demonstrated its similarity in structure and expression to rat PLP-C subfamily members. This level of conservation between species expands the biological significance of the PLP-C subfamily and provides additional opportunities for genetically evaluating its function.




This article has been cited by other articles:


Home page
 Genome ResHome page
M. G. Carter, T. Hamatani, A. A. Sharov, C. E. Carmack, Y. Qian, K. Aiba, N. T. Ko, D. B. Dudekula, P. M. Brzoska, S. S. Hwang, et al.
In Situ-Synthesized Novel Microarray Optimized for Mouse Stem Cell and Early Developmental Expression Profiling
Genome Res., May 1, 2003; 13(5): 1011 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. O. Wiemers, L.-j. Shao, R. Ain, G. Dai, and M. J. Soares
The Mouse Prolactin Gene Family Locus
Endocrinology, January 1, 2003; 144(1): 313 - 325.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I.-T. Hwang, Y.-H. Lee, B.-C. Moon, K.-Y. Ahn, S.-W. Lee, and J.-Y. Chun
Identification and Characterization of a New Member of the Placental Prolactin-Like Protein-C (PLP-C) Subfamily, PLP-C{beta}
Endocrinology, September 1, 2000; 141(9): 3343 - 3352.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. J. Toft and D. I.H. Linzer
Identification of Three Prolactin-Related Hormones as Markers of Invasive Trophoblasts in the Rat
Biol Reprod, August 1, 2000; 63(2): 519 - 525.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. T. FASSETT, R. T. HAMILTON, and M. NILSEN-HAMILTON
Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in this Gene Family for its Expression in the Adult Mouse Tail and Ear
Endocrinology, May 1, 2000; 141(5): 1863 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Su, S. A. Liebhaber, and N. E. Cooke
The Human Growth Hormone Gene Cluster Locus Control Region Supports Position-independent Pituitary- and Placenta-specific Expression in the Transgenic Mouse
J. Biol. Chem., March 10, 2000; 275(11): 7902 - 7909.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Toft and D. I. H. Linzer
Prolactin (PRL)-Like Protein J, a Novel Member of the PRL/Growth Hormone Family, Is Exclusively Expressed in Maternal Decidua
Endocrinology, November 1, 1999; 140(11): 5095 - 5101.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
G. Dai, M. W. Wolfe, and M. J. Soares
Distinct Regulatory Regions from the Prolactin-Like Protein C Variant Promoter Direct Trophoblast Giant Cell Versus Spongiotrophoblast Cell-Specific Expression
Endocrinology, October 1, 1999; 140(10): 4691 - 4698.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society