This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Reyes, J. L. Articles by Jaramillo-Juárez, F. Search for Related Content PubMed PubMed Citation Articles by Reyes, J. L. Articles by Jaramillo-Juárez, F.

Influence of Sex Differences on the Renal Secretion of Organic Anions

Department of Physiology (J.L.R., A.A.), Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, D.F. 07000; Department of Pharmacy (E.M.), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F. 11340; and Department of Pharmacology and Physiology (F.J.-J.), Centro Básico, Universidad Autónoma de Aguascalientes, Mexico, D.F. 20100

Address all correspondence and requests for reprints to: Jose L. Reyes, M.D., Ph.D., Department of Physiology and Biophysics, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, P.O. Box 14–740, México, D.F. 07000, Mexico. E-mail: jreyes{at}fisio.cinvestav.mx

The kidney’s responsiveness to male sexual hormones has been often neglected. Renal secretion of organic anions is higher in male than in female individuals; as a consequence, most of the xenobiotics that are excreted from the organism through this pathway are eliminated more rapidly by males than by female animals. To gain further insight into this issue, we studied in vitro and in vivo characteristics of the transport of p-aminohippurate (PAH), a suitable marker for this system, in male and female rats, under different hormonal conditions. Kinetics of PAH showed a shorter elimination half-time in male than in female rats (t_1/2el: male = 16.2 ± 2.1 min, female = 25.7 ± 4.5 min, P < 0.05). Castration of male rats increased t_1/2el to a value similar to that of female rats (t_1/2el: orchiectomized rat = 28.1 ± 7.1 min). Testosterone treatment of female rats increased the elimination rate to a value similar to that of male rats. In vitro PAH uptake by renal cortical slices from intact male rats was higher than that by slices from orchiectomized rats. Kinetic analyses of PAH uptake suggest that the difference was caused by a lower number of transporting molecules in orchiectomized than in intact animals, whereas the transporting capacity for each carrier was similar in male and in orchiectomized rats. Our results suggest that testosterone increases the number of functional carriers for PAH in the kidney.

This article has been cited by other articles:

				S.-Y. Ahn and S. K. Nigam Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis Mol. Pharmacol., September 1, 2009; 76(3): 481 - 490. [Abstract] [Full Text] [PDF]

				R. Schneider, C. Sauvant, B. Betz, M. Otremba, D. Fischer, H. Holzinger, C. Wanner, J. Galle, and M. Gekle Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1599 - F1605. [Abstract] [Full Text] [PDF]

				M. Ljubojevic, D. Balen, D. Breljak, M. Kusan, N. Anzai, A. Bahn, G. Burckhardt, and I. Sabolic Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones Am J Physiol Renal Physiol, January 1, 2007; 292(1): F361 - F372. [Abstract] [Full Text] [PDF]

				C. E. Groves, W. B. Suhre, N. J. Cherrington, and S. H. Wright Sex Differences in the mRNA, Protein, and Functional Expression of Organic Anion Transporter (Oat) 1, Oat3, and Organic Cation Transporter (Oct) 2 in Rabbit Renal Proximal Tubules J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 743 - 752. [Abstract] [Full Text] [PDF]

				R. Ogawa, R. Kishi, K. Mihara, H. Takahashi, A. Takagi, N. Matsumoto, K. Masuhara, K. Nakazawa, F. Miyake, S. Kobayashi, et al. Population Pharmacokinetic and Pharmacodynamic Analysis of a Class IC Antiarrhythmic, Pilsicainide, in Patients With Cardiac Arrhythmias J. Clin. Pharmacol., January 1, 2006; 46(1): 59 - 68. [Abstract] [Full Text] [PDF]

				C. Sauvant, H. Holzinger, and M. Gekle Prostaglandin E2 Inhibits Its Own Renal Transport by Downregulation of Organic Anion Transporters rOAT1 and rOAT3 J. Am. Soc. Nephrol., January 1, 2006; 17(1): 46 - 53. [Abstract] [Full Text] [PDF]

				M. Ljubojevic, C. M. Herak-Kramberger, Y. Hagos, A. Bahn, H. Endou, G. Burckhardt, and I. Sabolic Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition Am J Physiol Renal Physiol, July 1, 2004; 287(1): F124 - F138. [Abstract] [Full Text] [PDF]

				S. C. N. Buist, N. J. Cherrington, S. Choudhuri, D. P. Hartley, and C. D. Klaassen Gender-Specific and Developmental Influences on the Expression of Rat Organic Anion Transporters J. Pharmacol. Exp. Ther., April 1, 2002; 301(1): 145 - 151. [Abstract] [Full Text] [PDF]