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in Bovine Endometrial Cells1
Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Québec J2S 7C6, Canada
Address all correspondence and requests for reprints to: A. K. Goff, Centre de Recherche en Reproduction Animale, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Rue Sicotte, St-Hyacinthe, Québec J2S 7C6, Canada. E-mail: goffak{at}medvet.umontreal.ca
Estradiol (E2) and progesterone are responsible for regulating PG
synthesis in the endometrium during the estrous cycle and
interferon-
(IFN-) alters PG synthesis during early pregnancy in
ruminants. In this study, we examined the effects of these steroid
hormones and recombinant bovine IFN- (rbIFN-) on PG production
and on cyclooxygenase-2 (COX-2) and PG F (PGF) synthase (PGFS) gene
expression in isolated endometrial cells. E2 decreased both
PGF2
and PG E2 (PGE2) whereas
progesterone increased PGF2 secretion in epithelial
cells. Steroid hormones had no effect on PG production in stromal
cells. rbIFN- attenuated both PGF2 and
PGE2 production in epithelial cells and enhanced their
production, and the ratio of PGE2 to PGF2,
in stromal cells. Northern blot analysis showed that E2 and rbIFN-
decreased COX-2 messenger RNA (mRNA) levels in epithelial cells.
Conversely, rbIFN- increased COX-2 mRNA in stromal cells.
Furthermore, rbIFN- decreased PGFS mRNA in both cell types and this
was associated with the increase in
PGE2/PGF2 ratio. These results show that the
regulation of PG synthesis by steroid hormones is different in
endometrial epithelial and stromal cells in vitro. The
attenuation of PGF2 secretion from epithelial cells and
increased PGE2 production in stromal cells by rbIFN- are
modulated by steroid hormones.
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