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Differential Expression of Peroxisome Proliferator-Activated Receptor-, -ß, and - during Rat Embryonic Development¹

Institut de Biologie Animale, Université de Lausanne, 1015 Lausanne, Switzerland

Address all correspondence and requests for reprints to: Dr. Walter Wahli, Institut de Biologie Animale, Bâtiment de Biologie, Université de Lausanne, CH-1015 Lausanne, Switzerland. E-mail: walter.wahli{at}iba.unil.ch

The expression patterns of the three different peroxisome proliferator-activated receptor (PPAR) isotypes have been determined during rat embryonic development by in situ hybridization. The expression of PPAR starts late in development, with increasing levels in organs such as liver, kidney, intestine, and pancreas, in which it will also be present later in adulthood to regulate its specific target genes. PPAR is also transiently expressed in the embryonic epidermis and central nervous system. PPAR presents a very restricted pattern of expression, being strongly expressed in brown adipose tissue, in which differentiation it has been shown to participate. Like PPAR, it is also expressed transiently in the central nervous system. Interestingly, PPAR, -ß and - are coexpressed at high levels in brown adipose tissue. Finally, the high and ubiquitous expression of PPARß suggests some fundamental role(s) that this receptor might play throughout development.

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