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Endocrinology Vol. 139, No. 6 3018-3021
Copyright © 1998 by The Endocrine Society

ARTICLES

Neuropeptide Y Lowers Blood Glucose in Anaesthetized Rats via a Y5 Receptor Subtype

Angela Bischoff and Martin C. Michel

Medizinische Klinik, Klinikum Essen, 45122 Essen, Germany

Address all correspondence and requests for reprints to: Martin C. Michel, M.D., Universitätsklinikum Essen, Nephrol. Lab. IG 1, Klinikum, Hufelandstrasse 55, Essen 45122, Germany.

We have investigated the receptor subtype mediating effects of neuropeptide Y (NPY) on blood glucose concentrations. In anaesthetized rats a 120 min i.v. infusion of 2 µg/kg/min NPY lowered blood glucose by 26 mg/dl. This was mimicked by the same dose of peptide YY (PYY), NPY2-36, PYY3-36 and [Leu31,Pro34] NPY but not by NPY13-36, PYY13-36 or rat or human pancreatic polypeptide. The effects of NPY and [Leu31,Pro34]NPY were not inhibited by 10 µg/kg/min BIBP 3226. Neither treatment significantly altered plasma insulin concentrations. We conclude that NPY lowers blood glucose concentrations via a Y5 receptor subtype, i.e. a subtype which has also been implicated in stimulation of food intake.




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Copyright © 1998 by The Endocrine Society