help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lorenzo, J. A.
Right arrow Articles by Pilbeam, C. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lorenzo, J. A.
Right arrow Articles by Pilbeam, C. C.
Endocrinology Vol. 139, No. 6 3022-3025
Copyright © 1998 by The Endocrine Society

ARTICLES

Mice Lacking the Type I Interleukin-1 Receptor Do Not Lose Bone Mass after Ovariectomy

Joseph A. Lorenzo, Anica Naprta, Yue Rao, Cynthia Alander, Moira Glaccum, Michael Widmer, Gloria Gronowicz, Judith Kalinowski and Carol C. Pilbeam

VA Connecticut Healthcare System (J.A.L., J.K.), Newington, Connecticut 06111; The Departments of Medicine (Y.R., C.A., C.C.P.) and Orthopedics (A.N., G.G.), University of Connecticut Health Center, Farmington, Connecticut 06030; and Immunex Research and Development Corporation (M.G., M.W.), Seattle, Washington 98101

Address all correspondence and requests for reprints to: Joseph Lorenzo, M.D., VA Connecticut Healthcare System, 555 Willard Avenue, Building 5, Research, Newington, Connecticut 06111.

We measured the effects of ovariectomy on the bone mass of mice that lacked type I interleukin-1 receptor (IL-1 R1 -/- mice) in two genetic backgrounds (C57BL/6 x 129/Sv and C57BL/6) to investigate the role of interleukin-1 in the actions of estrogen on bone. At three weeks after surgery, ovariectomized wild-type mice decreased trabecular bone volume in the proximal humerus by 70% in a C57BL/6 x 129/Sv background and 48% in a C57BL/6 background compared to sham-operated controls. In contrast, there was no significant decrease in trabecular bone mass in IL-1 R1 -/- mice after ovariectomy. The estrogen status of all groups was confirmed by measurement of uterine wet weight. These results demonstrate that a functional IL-1 response pathway is required for mice to lose trabecular bone mass after ovariectomy in this model and they imply that IL-1 is an important mediator of the effects of ovariectomy on bone mass. Hence, therapeutic interventions that block the effects of IL-1 on bone may be beneficial for treating diseases of rapid bone loss such as post-menopausal osteoporosis.




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
J. Lorenzo, M. Horowitz, and Y. Choi
Osteoimmunology: Interactions of the Bone and Immune System
Endocr. Rev., June 1, 2008; 29(4): 403 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
D. G. Phinney and D. J. Prockop
Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair Current Views
Stem Cells, November 1, 2007; 25(11): 2896 - 2902.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Ortiz, M. DuTreil, C. Fattman, A. C. Pandey, G. Torres, K. Go, and D. G. Phinney
Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
PNAS, June 26, 2007; 104(26): 11002 - 11007.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
U.H. Lerner
Bone Remodeling in Post-menopausal Osteoporosis.
J. Dent. Res., July 1, 2006; 85(7): 584 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
Ph. Lesclous, F. Schramm, S. Gallina, B. Baroukh, D. Guez, and J. L. Saffar
Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats
Exp Physiol, May 1, 2006; 91(3): 561 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Ha, J.-H. Lee, H.-N. Kim, H.-M. Kim, H. B. Kwak, S. Lee, H.-H. Kim, and Z. H. Lee
{alpha}-Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis
J. Immunol., January 1, 2006; 176(1): 111 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Bajayo, I. Goshen, S. Feldman, V. Csernus, K. Iverfeldt, E. Shohami, R. Yirmiya, and I. Bab
Central IL-1 receptor signaling regulates bone growth and mass
PNAS, September 6, 2005; 102(36): 12956 - 12961.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
S. Dayan, P. Stashenko, R. Niederman, and T.S. Kupper
Oral Epithelial Overexpression of IL-1{alpha} Causes Periodontal Disease
J. Dent. Res., October 1, 2004; 83(10): 786 - 790.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth
Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification
Endocr. Rev., August 1, 2004; 25(4): 629 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Cenci, G. Toraldo, M. N. Weitzmann, C. Roggia, Y. Gao, W. P. Qian, O. Sierra, and R. Pacifici
Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-{gamma}-induced class II transactivator
PNAS, September 2, 2003; 100(18): 10405 - 10410.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Katavic, I. K. Lukic, N. Kovacic, D. Grcevic, J. A. Lorenzo, and A. Marusic
Increased Bone Mass Is a Part of the Generalized Lymphoproliferative Disorder Phenotype in the Mouse
J. Immunol., February 1, 2003; 170(3): 1540 - 1547.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. P. Armstrong, M. E. Tometsko, M. Glaccum, C. L. Sutherland, D. Cosman, and W. C. Dougall
A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function
J. Biol. Chem., November 8, 2002; 277(46): 44347 - 44356.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-K. Lee, J. Kalinowski, S. Jastrzebski, and J. A. Lorenzo
1,25 (OH)2 Vitamin D3-Stimulated Osteoclast Formation in Spleen-Osteoblast Cocultures Is Mediated in Part by Enhanced IL-1{alpha} and Receptor Activator of NF-{kappa}B Ligand Production in Osteoblasts
J. Immunol., September 1, 2002; 169(5): 2374 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz
Changes in Proinflammatory Cytokine Activity after Menopause
Endocr. Rev., February 1, 2002; 23(1): 90 - 119.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A Nemetz, M Toth, M A Garcia-Gonzalez, T Zagoni, J Feher, A S Pena, and Z Tulassay
Allelic variation at the interleukin 1{beta} gene is associated with decreased bone mass in patients with inflammatory bowel diseases
Gut, November 1, 2001; 49(5): 644 - 649.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Saika, D. Inoue, S. Kido, and T. Matsumoto
17{beta}-Estradiol Stimulates Expression of Osteoprotegerin by a Mouse Stromal Cell Line, ST-2, via Estrogen Receptor-{{alpha}}
Endocrinology, June 1, 2001; 142(6): 2205 - 2212.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Yoshitake, S. R. Rittling, D. T. Denhardt, and M. Noda
Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
PNAS, July 6, 1999; 96(14): 8156 - 8160.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Franchimont, D. Durant, S. Rydziel, and E. Canalis
Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2
J. Biol. Chem., March 5, 1999; 274(10): 6783 - 6789.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. K. Lea, U. Sarma, and A. M. Flanagan
Macrophage Colony Stimulating-Factor Transcripts Are Differentially Regulated in Rat Bone-Marrow by Gender Hormones
Endocrinology, January 1, 1999; 140(1): 273 - 279.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
R. Pacifici
Editorial: Cytokines, Estrogen, and Postmenopausal Osteoporosis--The Second Decade
Endocrinology, June 1, 1998; 139(6): 2659 - 2661.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Miyaura, M. Inada, T. Suzawa, Y. Sugimoto, F. Ushikubi, A. Ichikawa, S. Narumiya, and T. Suda
Impaired Bone Resorption to Prostaglandin E2 in Prostaglandin E Receptor EP4-knockout Mice
J. Biol. Chem., June 23, 2000; 275(26): 19819 - 19823.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Srivastava, G. Toraldo, M. N. Weitzmann, S. Cenci, F. P. Ross, and R. Pacifici
Estrogen Decreases Osteoclast Formation by Down-regulating Receptor Activator of NF-kappa B Ligand (RANKL)-induced JNK Activation
J. Biol. Chem., March 16, 2001; 276(12): 8836 - 8840.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Ogawa, M. Fujita, Y. Ishii, H. Tsurukami, M. Hirabayashi, K. Ikeda, A. Orimo, T. Hosoi, M. Ueda, T. Nakamura, et al.
Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor alpha and beta Pathways
J. Biol. Chem., July 7, 2000; 275(28): 21372 - 21379.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. J. van't Hof, K. J. Armour, L. M. Smith, K. E. Armour, X. Q. Wei, F. Y. Liew, and S. H. Ralston
Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption
PNAS, July 5, 2000; 97(14): 7993 - 7998.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society