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THE RESULTS OF ORAL ADMINISTRATION OF AMNIOTIN TO MONKEYS^*

From the Research and Biological Laboratories of E. R. Squibb & Sons NEW BRUNSWICK, N. J.

Abstract

In previous experimental work we showed that when amniotin is administered by the vaginal route 2.5 times as much was necessary as when injected subcutaneously to produce an artificial sex cycle. This ratio was found to be the same in spayed rats and in ovariectomized monkeys.

Until the present time no satisfactory evidence has been given to show whether or not the follicular hormone is active when given by mouth. Many have thought that the hormone was destroyed by the digestive enzymes. Hannan claims that he obtained an estrus reaction in spayed rats when he administered 100 times the ordinary dosage.

We administered amniotin by stomach tube to the ovariectomized monkeys (Macacus rhesus) in our colony. After some preliminary difficult in getting the stomach tube inserted no trouble was experienced. The amniotin was administered once a day for five consecutive days. All monkeys used had been under observation for months. All were completely ovariectomized. The ordinary commercial preparation of amniotin and special solutions of the hormone in alcohol and glycerin were used. No difference was noted in either the types of reaction nor the amounts necessary. Vaginal spreads were taken daily and observations made of the condition of the sexual skin.

Footnotes

^* Read before The Association for the Study of Internal Secretions, Detroit, Michigan, June 23, 1930.

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