help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meeran, K.
Right arrow Articles by Bloom, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meeran, K.
Right arrow Articles by Bloom, S. R.
Endocrinology Vol. 140, No. 1 244-250
Copyright © 1999 by The Endocrine Society

ARTICLES

Repeated Intracerebroventricular Administration of Glucagon-Like Peptide-1-(7–36) Amide or Exendin-(9–39) Alters Body Weight in the Rat1

Karim Meeran2, Donal O’Shea3, C. Mark B. Edwards4, Mandy D. Turton, Melanie M. Heath5, Irene Gunn, Salahedeen Abusnana, Michela Rossi, Caroline J. Small6, Anthony P. Goldstone2, Gillian M. Taylor5, David Sunter, Joanna Steere, Sang Jeon Choi, Mohammad A. Ghatei and Stephen R. Bloom

Imperial College School of Medicine Endocrine Unit, Hammersmith Hospital, London, United Kingdom W12 0NN

Address all correspondence and requests for reprints to: Prof. S. R. Bloom, ICSM Endocrine Unit, Hammersmith Hospital, Du Cane Road, London, United Kingdom W12 0HS. E-mail: sbloom{at}rpms.ac.uk

Central nervous system glucagon-like peptide-1-(7–36) amide (GLP-1) administration has been reported to acutely reduce food intake in the rat. We here report that repeated intracerebroventricular (icv) injection of GLP-1 or the GLP-1 receptor antagonist, exendin-(9–39), affects food intake and body weight. Daily icv injection of 3 nmol GLP-1 to schedule-fed rats for 6 days caused a reduction in food intake and a decrease in body weight of 16 ± 5 g (P < 0.02 compared with saline-injected controls). Daily icv administration of 30 nmol exendin-(9–39) to schedule-fed rats for 3 days caused an increase in food intake and increased body weight by 7 ± 2 g (P < 0.02 compared with saline-injected controls). Twice daily icv injections of 30 nmol exendin-(9–39) with 2.4 nmol neuropeptide Y to ad libitum-fed rats for 8 days increased food intake and increased body weight by 28 ± 4 g compared with 14 ± 3 g in neuropeptide Y-injected controls (P < 0.02). There was no evidence of tachyphylaxis in response to icv GLP-1 or exendin-(9–39). GLP-1 may thus be involved in the regulation of body weight in the rat.




This article has been cited by other articles:


Home page
 EndocrinologyHome page
M. R. Hayes, K. P. Skibicka, and H. J. Grill
Caudal Brainstem Processing Is Sufficient for Behavioral, Sympathetic, and Parasympathetic Responses Driven by Peripheral and Hindbrain Glucagon-Like-Peptide-1 Receptor Stimulation
Endocrinology, August 1, 2008; 149(8): 4059 - 4068.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
T. Jin
Mechanisms underlying proglucagon gene expression
J. Endocrinol., July 1, 2008; 198(1): 17 - 28.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Yi, J. Sun, G. E. Lim, I. G. Fantus, P. L. Brubaker, and T. Jin
Cross Talk between the Insulin and Wnt Signaling Pathways: Evidence from Intestinal Endocrine L Cells
Endocrinology, May 1, 2008; 149(5): 2341 - 2351.
[Abstract] [Full Text] [PDF]

Home page
 The Diabetes EducatorHome page
C. L. Martin
Beyond Glycemic Control: The Effects of Incretin Hormones in Type 2 Diabetes
The Diabetes Educator, May 1, 2008; 34(Supplement_3): 66S - 72S.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Huo, K. M. Gamber, H. J. Grill, and C. Bjorbaek
Divergent Leptin Signaling in Proglucagon Neurons of the Nucleus of the Solitary Tract in Mice and Rats
Endocrinology, February 1, 2008; 149(2): 492 - 497.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Ma, J. Bruning, and F. M. Ashcroft
Glucagon-Like Peptide 1 Stimulates Hypothalamic Proopiomelanocortin Neurons
J. Neurosci., July 4, 2007; 27(27): 7125 - 7129.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Raun, P. von Voss, C. F. Gotfredsen, V. Golozoubova, B. Rolin, and L. B. Knudsen
Liraglutide, a Long-Acting Glucagon-Like Peptide-1 Analog, Reduces Body Weight and Food Intake in Obese Candy-Fed Rats, Whereas a Dipeptidyl Peptidase-IV Inhibitor, Vildagliptin, Does Not
Diabetes, January 1, 2007; 56(1): 8 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. G. Murphy, W. S. Dhillo, and S. R. Bloom
Gut Peptides in the Regulation of Food Intake and Energy Homeostasis
Endocr. Rev., December 1, 2006; 27(7): 719 - 727.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. D. Cani, C. Knauf, M. A. Iglesias, D. J. Drucker, N. M. Delzenne, and R. Burcelin
Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like Peptide 1 receptor.
Diabetes, May 1, 2006; 55(5): 1484 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Wang, T. Liu, Z. Li, X. Ma, and T. Jin
Redundant and Synergistic Effect of Cdx-2 and Brn-4 on Regulating Proglucagon Gene Expression
Endocrinology, April 1, 2006; 147(4): 1950 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. K. Chelikani, A. C. Haver, and R. D. Reidelberger
Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1695 - R1706.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. K. Badman and J. S. Flier
The Gut and Energy Balance: Visceral Allies in the Obesity Wars
Science, March 25, 2005; 307(5717): 1909 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K. Wynne, S. Stanley, B. McGowan, and S. Bloom
Appetite control
J. Endocrinol., February 1, 2005; 184(2): 291 - 318.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Yi, P. L. Brubaker, and T. Jin
TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by {beta}-Catenin and Glycogen Synthase Kinase-3{beta}
J. Biol. Chem., January 14, 2005; 280(2): 1457 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. L. Baggio, J.-G. Kim, and D. J. Drucker
Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R-Dependent Glucose Homeostasis In Vivo
Diabetes, December 1, 2004; 53(suppl_3): S205 - S214.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Acuna-Goycolea and A. van den Pol
Glucagon-Like Peptide 1 Excites Hypocretin/Orexin Neurons by Direct and Indirect Mechanisms: Implications for Viscera-Mediated Arousal
J. Neurosci., September 15, 2004; 24(37): 8141 - 8152.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
K.G. Murphy and S.R. Bloom
Gut hormones in the control of appetite
Exp Physiol, September 1, 2004; 89(5): 507 - 516.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Wynne, S. Stanley, and S. Bloom
The Gut and Regulation of Body Weight
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2576 - 2582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Stanley, K. Wynne, and S. Bloom
Gastrointestinal Satiety Signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide
Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G693 - G697.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
D. J. Drucker
Enhancing Incretin Action for the Treatment of Type 2 Diabetes
Diabetes Care, October 1, 2003; 26(10): 2929 - 2940.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. R. Schick, J. P. Zimmermann, T. v. Walde, and V. Schusdziarra
Peptides that Regulate Food Intake: Glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1427 - R1435.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Ni, Y. Anini, X. Fang, G. Mills, P. L Brubaker, and T. Jin
Transcriptional Activation of the Proglucagon Gene by Lithium and beta -Catenin in Intestinal Endocrine L Cells
J. Biol. Chem., January 3, 2003; 278(2): 1380 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. P. Kinzig, D. A. D'Alessio, and R. J. Seeley
The Diverse Roles of Specific GLP-1 Receptors in the Control of Food Intake and the Response to Visceral Illness
J. Neurosci., December 1, 2002; 22(23): 10470 - 10476.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. L. Dakin, C. J. Small, A. J. Park, A. Seth, M. A. Ghatei, and S. R. Bloom
Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats
Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1173 - E1177.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. E. MacDonald, W. El-kholy, M. J. Riedel, A. M. F. Salapatek, P. E. Light, and M. B. Wheeler
The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion
Diabetes, December 1, 2002; 51(90003): S434 - 442.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. Perry, N. J. Haughey, M. P. Mattson, J. M. Egan, and N. H. Greig
Protection and Reversal of Excitotoxic Neuronal Damage by Glucagon-Like Peptide-1 and Exendin-4
J. Pharmacol. Exp. Ther., September 1, 2002; 302(3): 881 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
P. J. Havel
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
C. T. Peters, Y.-H. Choi, P. L. Brubaker, and G. H. Anderson
A Glucagon-Like Peptide-1 Receptor Agonist and an Antagonist Modify Macronutrient Selection by Rats
J. Nutr., August 1, 2001; 131(8): 2164 - 2170.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. M. B. Edwards, S. A. Stanley, R. Davis, A. E. Brynes, G. S. Frost, L. J. Seal, M. A. Ghatei, and S. R. Bloom
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers
Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E155 - E161.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
Y.-H. Choi and G. H. Anderson
An Interaction between Hypothalamic Glucagon-Like Peptide-1 and Macronutrient Composition Determines Food Intake in Rats
J. Nutr., June 1, 2001; 131(6): 1819 - 1825.
[Abstract] [Full Text]

Home page
 Diabetes CareHome page
M. Zander, M. Taskiran, M.-B. Toft-Nielsen, S. Madsbad, and J. J. Holst
Additive Glucose-Lowering Effects of Glucagon-Like Peptide-1 and Metformin in Type 2 Diabetes
Diabetes Care, April 1, 2001; 24(4): 720 - 725.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
A. INUI
Transgenic study of energy homeostasis equation: implications and confounding influences
FASEB J, November 1, 2000; 14(14): 2158 - 2170.
[Abstract] [Full Text]

Home page
 Pharmacol. Rev.Home page
A. Inui
Transgenic Approach to the Study of Body Weight Regulation
Pharmacol. Rev., March 1, 2000; 52(1): 35 - 62.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. J. MacLusky, S. Cook, L. Scrocchi, J. Shin, J. Kim, F. Vaccarino, S. L. Asa, and D. J. Drucker
Neuroendocrine Function and Response to Stress in Mice with Complete Disruption of Glucagon-Like Peptide-1 Receptor Signaling
Endocrinology, February 1, 2000; 141(2): 752 - 762.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Baggio, F. Adatia, T. Bock, P. L. Brubaker, and D. J. Drucker
Sustained Expression of Exendin-4 Does Not Perturb Glucose Homeostasis, beta -Cell Mass, or Food Intake in Metallothionein-Preproexendin Transgenic Mice
J. Biol. Chem., October 27, 2000; 275(44): 34471 - 34477.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Lovshin, J. Estall, B. Yusta, T. J. Brown, and D. J. Drucker
Glucagon-like Peptide (GLP)-2 Action in the Murine Central Nervous System Is Enhanced by Elimination of GLP-1 Receptor Signaling
J. Biol. Chem., June 8, 2001; 276(24): 21489 - 21499.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society