help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacobson, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacobson, L.
Endocrinology Vol. 140, No. 1 310-317
Copyright © 1999 by The Endocrine Society

ARTICLES

Glucocorticoid Replacement, but not Corticotropin-Releasing Hormone Deficiency, Prevents Adrenalectomy-Induced Anorexia in Mice1

Lauren Jacobson

Division of Endocrinology, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115

Address all correspondence and requests for reprints to: Dr. Lauren Jacobson, Division of Endocrinology, Children’s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115. E-mail: jacobson{at}a1.tch.harvard.edu

There is considerable evidence that CRH can suppress food intake. As hypothalamic CRH, a main site of CRH expression, is also negatively regulated by glucocorticoids, it is unclear whether anorexia and weight loss in adrenal insufficiency are attributable to elevated CRH or to decreased glucocorticoid levels. To distinguish these possibilities, we have measured food intake and body weight in wild-type and CRH-deficient mice after sham adrenalectomy (Sham ADX) or adrenalectomy (ADX) with and without corticosterone (B) replacement. CRH deficiency neither increased basal food intake and body weight nor attenuated decreases in food intake after ADX or Sham ADX. B replacement producing plasma levels above the circadian peak completely blocked ADX-induced decreases in feeding and body weight in all mice and frequently stimulated food intake in CRH-deficient mice. Plasma levels of insulin and leptin, two other hormones involved in appetite regulation, did not differ between genotypes; however, the relationship between food intake and circulating leptin was significantly less negative at B doses that preserved appetite. B replacement levels slightly below circadian peak concentrations did not prevent hypophagia after ADX. We conclude that factors other than or in addition to CRH are more important in mediating appetite responses to adrenalectomy.




This article has been cited by other articles:


Home page
 EndocrinologyHome page
J. Gay, E. Kokkotou, M. O'Brien, C. Pothoulakis, and K. P. Karalis
Corticotropin-Releasing Hormone Deficiency Is Associated with Reduced Local Inflammation in a Mouse Model of Experimental Colitis
Endocrinology, July 1, 2008; 149(7): 3403 - 3409.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. T. Fueger, C. Y. Li, J. E. Ayala, J. Shearer, D. P. Bracy, M. J. Charron, J. N. Rottman, and D. H. Wasserman
Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter
J. Physiol., July 15, 2007; 582(2): 801 - 812.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Jacobson, T. Ansari, J. Potts, and O. P. McGuinness
Glucocorticoid-deficient corticotropin-releasing hormone knockout mice maintain glucose requirements but not autonomic responses during repeated hypoglycemia
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E15 - E22.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Jacobson, T. Ansari, and O. P. McGuinness
Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice
Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E678 - E684.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Kier, J. Han, and L. Jacobson
Chronic Treatment with the Monoamine Oxidase Inhibitor Phenelzine Increases Hypothalamic-Pituitary-Adrenocortical Activity in Male C57BL/6 Mice: Relevance to Atypical Depression
Endocrinology, March 1, 2005; 146(3): 1338 - 1347.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. E. la Fleur, S. F. Akana, S. L. Manalo, and M. F. Dallman
Interaction between Corticosterone and Insulin in Obesity: Regulation of Lard Intake and Fat Stores
Endocrinology, May 1, 2004; 145(5): 2174 - 2185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Madiehe, L. Lin, C. White, H. D. Braymer, G. A. Bray, and D. A. York
Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2048 - R2058.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. W. Woitge, J. R. Harrison, A. Ivkosic, Z. Krozowski, and B. E. Kream
Cloning and in Vitro Characterization of {{alpha}}1(I)-Collagen 11{{beta}}-Hydroxysteroid Dehydrogenase Type 2 Transgenes as Models for Osteoblast-Selective Inactivation of Natural Glucocorticoids
Endocrinology, March 1, 2001; 142(3): 1341 - 1348.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. INUI
Transgenic study of energy homeostasis equation: implications and confounding influences
FASEB J, November 1, 2000; 14(14): 2158 - 2170.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Valles, O. Marti, A. Garcia, and A. Armario
Single exposure to stressors causes long-lasting, stress-dependent reduction of food intake in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R1138 - R1144.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. J. Bradbury, M. I. McBurnie, D. A. Denton, K.-F. Lee, and W. W. Vale
Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice
Endocrinology, August 1, 2000; 141(8): 2715 - 2724.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Venihaki, A. Carrigan, P. Dikkes, and J. A. Majzoub
Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency
PNAS, June 20, 2000; 97(13): 7336 - 7341.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. Inui
Transgenic Approach to the Study of Body Weight Regulation
Pharmacol. Rev., March 1, 2000; 52(1): 35 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Solano and L. Jacobson
Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA
Am J Physiol Endocrinol Metab, October 1, 1999; 277(4): E708 - E716.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Jacobson
Lower Weight Loss and Food Intake in Protein-Deprived, Corticotropin Releasing Hormone-Deficient Mice Correlate with Glucocorticoid Insufficiency
Endocrinology, August 1, 1999; 140(8): 3543 - 3551.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. P. Karalis, E. Kontopoulos, L. J. Muglia, and J. A. Majzoub
Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine
PNAS, June 8, 1999; 96(12): 7093 - 7097.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society