This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Toft, D. J. Articles by Linzer, D. I. H. Search for Related Content PubMed PubMed Citation Articles by Toft, D. J. Articles by Linzer, D. I. H.

Prolactin (PRL)-Like Protein J, a Novel Member of the PRL/Growth Hormone Family, Is Exclusively Expressed in Maternal Decidua¹

Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208

Address all correspondence and requests for reprints to: Dr. Daniel I. H. Linzer, Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, Illinois 60208. E-mail: dlinzer{at}nwu.edu

A search of a nonmouse, nonhuman, expressed sequence tag database for messenger RNAs in the PRL/GH family has identified a novel rat complementary DNA clone. The encoded protein, designated PRL-like protein J (PLP-J), is predicted to be synthesized as a precursor of 211 amino acids, modified by N-linked glycosylation, and secreted as a mature glycoprotein of 182 residues. PLP-J messenger RNA synthesis is limited to early pregnancy with abundant expression on day 7, slightly declining expression on day 9, and no detectable expression by day 11. Unlike most other PRL family members, PLP-J does not appear to be synthesized by placental trophoblasts but, rather, by decidual cells surrounding the implantation site. By sequence similarity to rat PLP-J, a murine clone was identified in a mouse expressed sequence tag database. Mouse PLP-J was used to map the gene to a 700-kb region of mouse chromosome 13 that includes other members of the PRL/GH family.

This article has been cited by other articles:

				S. M. K. Alam, T. Konno, N. Sahgal, L. Lu, and M. J. Soares Decidual Cells Produce a Heparin-binding Prolactin Family Cytokine with Putative Intrauterine Regulatory Actions J. Biol. Chem., July 4, 2008; 283(27): 18957 - 18968. [Abstract] [Full Text] [PDF]

				S. M. K. Alam, T. Konno, G. Dai, L. Lu, D. Wang, J. H. Dunmore, A. R. Godwin, and M. J. Soares A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor Development, January 15, 2007; 134(2): 407 - 415. [Abstract] [Full Text] [PDF]

				D. O. Wiemers, L.-j. Shao, R. Ain, G. Dai, and M. J. Soares The Mouse Prolactin Gene Family Locus Endocrinology, January 1, 2003; 144(1): 313 - 325. [Abstract] [Full Text] [PDF]

				M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy Prolactin: Structure, Function, and Regulation of Secretion Physiol Rev, October 1, 2000; 80(4): 1523 - 1631. [Abstract] [Full Text] [PDF]

				I.-T. Hwang, Y.-H. Lee, B.-C. Moon, K.-Y. Ahn, S.-W. Lee, and J.-Y. Chun Identification and Characterization of a New Member of the Placental Prolactin-Like Protein-C (PLP-C) Subfamily, PLP-C{beta} Endocrinology, September 1, 2000; 141(9): 3343 - 3352. [Abstract] [Full Text] [PDF]

				D. J. Toft and D. I.H. Linzer Identification of Three Prolactin-Related Hormones as Markers of Invasive Trophoblasts in the Rat Biol Reprod, August 1, 2000; 63(2): 519 - 525. [Abstract] [Full Text]