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Expression of Growth Hormone and Its Receptor in the Placental and Feto-Maternal Environment during Early Pregnancy in Sheep

Unité de Biologie Cellulaire et Moléculaire, Institut National de la Recherche Agronomique (M.C.L., E.D., S.C., J.L.S., G.K.), 78352 Jouy en Josas, France; Laboratoire de Génétique Moléculaire, Faculté de Pharmacie (M.V.), 75006 Paris, France

Address all correspondence and requests for reprints to: Dr. Marie-Christine Lacroix, Unité de Biologie Cellulaire et Moléculaire, Institut National de la Recherche Agronomique, 78352 Jouy en Josas, France. E-mail: lacroix{at}jouy.inra.fr

In a previous study we showed the existence of GH in the ovine placenta. We now supplement the information available on placental GH and describe the presence and distribution of GH receptor (GH-R) messenger RNA (mRNA) in uterine, fetal, and placental tissues during early pregnancy. GH mRNA was not detected in the placenta before day 27 (d27). Its expression peaked between d40 and d45 and fell after d55. GH mRNA was localized in the trophectoderm and syncytium. During the d35-d50 period, concentrations of GH in the maternal circulation were not increased. In umbilical blood, however, GH was detected from d35 and was presumed to be of placental origin, because GH mRNA was not detected in the fetal pituitary gland on d40. We report on GH-R mRNA expression in the placenta between d20-d120. The relative abundance of GH-R transcripts increased significantly between d25-d43. In the endometrium, GH-R mRNA was detected from d8-d120 of pregnancy and from d4-d16 of the cycle. GH-R mRNA was localized in the trophectoderm, fetal mesoderm, and maternal uterine stroma. In the fetal liver, GH-R mRNA was first detectable on d35. The results of this study indicate that between d35-d50 of pregnancy, the endometrium, placenta, and fetus are all potential targets for the placental GH.

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