help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Durlinger, A. L. L.
Right arrow Articles by Themmen, A. P. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Durlinger, A. L. L.
Right arrow Articles by Themmen, A. P. N.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Hazardous Substances DB
*MENOTROPINS
Endocrinology Vol. 140, No. 12 5789-5796
Copyright © 1999 by The Endocrine Society

ARTICLES

Control of Primordial Follicle Recruitment by Anti-Müllerian Hormone in the Mouse Ovary1

Alexandra L. L. Durlinger, Piet Kramer, Bas Karels, Frank H. de Jong, Jan Th. J. Uilenbroek, J. Anton Grootegoed and Axel P. N. Themmen

Department of Endocrinology and Reproduction, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands

Address all correspondence and requests for reprints to: Dr. A. L. L. Durlinger, Department of Endocrinology and Reproduction, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. E-mail: durlinger{at}endov.fgg.eur.nl

The dimeric glycoprotein anti-Müllerian hormone (AMH) is a member of the transforming growth factor-ß superfamily of growth and differentiation factors. During male fetal sex differentiation, AMH is produced by Sertoli cells and induces degeneration of the Müllerian ducts, which form the anlagen of part of the internal female genital system. In females, AMH is produced by the ovary, but only postnatally. The function of AMH in the ovary is, however, still unknown. Female AMH null mice were reported to be fertile, with normal litter size, but this does not exclude a more subtle function for ovarian AMH.

To investigate the function of AMH in the ovary, the complete follicle population was determined in AMH null mice, in mice heterozygous for the AMH null mutation, and in wild-type mice of different ages: 25 days, 4 months, and 13 months. In the present study we found that ovaries of 25-day- and 4-month-old AMH null females, compared to those of wild-type females, contain more preantral and small antral follicles. In addition, in 4- and 13-month-old AMH null females, smaller numbers of primordial follicles were found. Actually, in 13-month-old AMH null females, almost no primordial follicles could be detected, coinciding with a reduced number of preantral and small antral follicles in these females. In almost all females heterozygous for the AMH null mutation the number of follicles fell in between the numbers found in wild-type and AMH null females. In 4-month-old AMH null females serum inhibin levels were higher and FSH levels were lower compared to those in wild-type females. In contrast, inhibin levels were lower in 13-month-old AMH null females, and FSH levels were unchanged compared to those in wild-type females. Furthermore, the weight of the ovaries was twice as high in the 4-month-old AMH null females as in age-matched wild-type females.

We conclude that AMH plays an important role in primordial follicle recruitment, such that more primordial follicles are recruited in AMH null mice than in wild-type mice; the mice heterozygous for the AMH null mutation take an in-between position. Consequently, the ovaries of AMH null females and those of females heterozygous for the AMH null mutation will show a relatively early depletion of their stock of primordial follicles. The female AMH null mouse may thus provide a useful model to study regulation of primordial follicle recruitment and the relation between follicular dynamics and ovarian aging.




This article has been cited by other articles:


Home page
 Mol Hum ReprodHome page
C. Tingen, A. Kim, and T. K. Woodruff
The primordial pool of follicles and nest breakdown in mammalian ovaries
Mol. Hum. Reprod., December 1, 2009; 15(12): 795 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S.A. Amer, T.C. Li, and W.L. Ledger
The value of measuring anti-Mullerian hormone in women with anovulatory polycystic ovary syndrome undergoing laparoscopic ovarian diathermy
Hum. Reprod., November 1, 2009; 24(11): 2760 - 2766.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. A. Edson, A. K. Nagaraja, and M. M. Matzuk
The Mammalian Ovary from Genesis to Revelation
Endocr. Rev., October 1, 2009; 30(6): 624 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. La Marca, F.J. Broekmans, A. Volpe, B.C. Fauser, N.S. Macklon, and on behalf of the ESHRE Special Interest Group for
Anti-Mullerian hormone (AMH): what do we still need to know?
Hum. Reprod., September 1, 2009; 24(9): 2264 - 2275.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. Adhikari and K. Liu
Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles
Endocr. Rev., August 1, 2009; 30(5): 438 - 464.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
F. J. Broekmans, M. R. Soules, and B. C. Fauser
Ovarian Aging: Mechanisms and Clinical Consequences
Endocr. Rev., August 1, 2009; 30(5): 465 - 493.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
P A Johnson, T R Kent, M E Urick, L S Trevino, and J R Giles
Expression of anti-Mullerian hormone in hens selected for different ovulation rates
Reproduction, May 1, 2009; 137(5): 857 - 863.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
P. Rodrigues, D. Limback, L. K McGinnis, C. E Plancha, and D. F Albertini
Multiple mechanisms of germ cell loss in the perinatal mouse ovary
Reproduction, April 1, 2009; 137(4): 709 - 720.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
X. Wu, S. Wan, S. Pujar, M. E. Haskins, D. H. Schlafer, M. M. Lee, and V. N. Meyers-Wallen
A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS Type II Receptor Is Responsible for Canine Persistent Mullerian Duct Syndrome
J Androl, January 1, 2009; 30(1): 46 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. E. Kevenaar, A. P.N. Themmen, A. J. van Kerkwijk, O. Valkenburg, A. G. Uitterlinden, F. H. de Jong, J. S.E. Laven, and J. A. Visser
Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome
Hum. Reprod., January 1, 2009; 24(1): 241 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Jayaprakasan, B.K. Campbell, J.F. Hopkisson, J.S. Clewes, I.R. Johnson, and N.J. Raine-Fenning
Effect of pituitary desensitization on the early growing follicular cohort estimated using anti-Mullerian hormone
Hum. Reprod., November 1, 2008; 23(11): 2577 - 2583.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. K. Nagaraja, C. Andreu-Vieyra, H. L. Franco, L. Ma, R. Chen, D. Y. Han, H. Zhu, J. E. Agno, P. H. Gunaratne, F. J. DeMayo, et al.
Deletion of Dicer in Somatic Cells of the Female Reproductive Tract Causes Sterility
Mol. Endocrinol., October 1, 2008; 22(10): 2336 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. R. Sowers, A. D. Eyvazzadeh, D. McConnell, M. Yosef, M. L. Jannausch, D. Zhang, S. Harlow, and J. F. Randolph Jr.
Anti-Mullerian Hormone and Inhibin B in the Definition of Ovarian Aging and the Menopause Transition
J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3478 - 3483.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Andreu-Vieyra, R. Chen, and M. M. Matzuk
Conditional Deletion of the Retinoblastoma (Rb) Gene in Ovarian Granulosa Cells Leads to Premature Ovarian Failure
Mol. Endocrinol., September 1, 2008; 22(9): 2141 - 2161.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Das, D.J. Gillott, E. Saridogan, and O. Djahanbakhch
Anti-Mullerian hormone is increased in follicular fluid from unstimulated ovaries in women with polycystic ovary syndrome
Hum. Reprod., September 1, 2008; 23(9): 2122 - 2126.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
J C Sadeu, T Adriaenssens, and J Smitz
Expression of growth differentiation factor 9, bone morphogenetic protein 15, and anti-Mullerian hormone in cultured mouse primary follicles
Reproduction, August 1, 2008; 136(2): 195 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. Monniaux, N. d. Clemente, J.-L. Touze, C. Belville, C. Rico, M. Bontoux, J.-Y. Picard, and S. Fabre
Intrafollicular Steroids and Anti-Mullerian Hormone During Normal and Cystic Ovarian Follicular Development in the Cow
Biol Reprod, August 1, 2008; 79(2): 387 - 396.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. A. Williams and P. Stanley
Mouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans
FASEB J, July 1, 2008; 22(7): 2273 - 2284.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
S. Franks, J. Stark, and K. Hardy
Follicle dynamics and anovulation in polycystic ovary syndrome
Hum. Reprod. Update, May 22, 2008; (2008) dmn015v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. E. Kevenaar, J. S. E. Laven, S. L. Fong, A. G. Uitterlinden, F. H. de Jong, A. P. N. Themmen, and J. A. Visser
A Functional Anti-Mullerian Hormone Gene Polymorphism Is Associated with Follicle Number and Androgen Levels in Polycystic Ovary Syndrome Patients
J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1310 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
E. W Kabithe and N. J Place
Photoperiod-dependent modulation of anti-Mullerian hormone in female Siberian hamsters, Phodopus sungorus
Reproduction, March 1, 2008; 135(3): 335 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. A. Pangas, X. Li, L. Umans, A. Zwijsen, D. Huylebroeck, C. Gutierrez, D. Wang, J. F. Martin, S. P. Jamin, R. R. Behringer, et al.
Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice
Mol. Cell. Biol., January 1, 2008; 28(1): 248 - 257.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P.A Johnson, T.R Kent, M.E Urick, and J.R Giles
Expression and Regulation of Anti-Mullerian Hormone in an Oviparous Species, the Hen
Biol Reprod, January 1, 2008; 78(1): 13 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. D. van Beek, M. M. van den Heuvel-Eibrink, J. S. E. Laven, F. H. de Jong, A. P. N. Themmen, F. G. Hakvoort-Cammel, C. van den Bos, H. van den Berg, R. Pieters, and S. M. P. F. de Muinck Keizer-Schrama
Anti-Mullerian Hormone Is a Sensitive Serum Marker for Gonadal Function in Women Treated for Hodgkin's Lymphoma during Childhood
J. Clin. Endocrinol. Metab., October 1, 2007; 92(10): 3869 - 3874.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. E. Kevenaar, A. P.N. Themmen, F. Rivadeneira, A. G. Uitterlinden, J. S.E. Laven, N. M. van Schoor, P. Lips, H. A.P. Pols, and J. A. Visser
A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
Hum. Reprod., September 1, 2007; 22(9): 2382 - 2388.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. D. Gallardo, G. B. John, L. Shirley, C. M. Contreras, E. A. Akbay, J. M. Haynie, S. E. Ward, M. J. Shidler, and D. H. Castrillon
Genomewide Discovery and Classification of Candidate Ovarian Fertility Genes in the Mouse
Genetics, September 1, 2007; 177(1): 179 - 194.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
E. Nilsson, N. Rogers, and M. K Skinner
Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition
Reproduction, August 1, 2007; 134(2): 209 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Tsepelidis, F. Devreker, I. Demeestere, A. Flahaut, Ch. Gervy, and Y. Englert
Stable serum levels of anti-Mullerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women
Hum. Reprod., July 1, 2007; 22(7): 1837 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Klattig, R. Sierig, D. Kruspe, B. Besenbeck, and C. Englert
Wilms' Tumor Protein Wt1 Is an Activator of the Anti-Mullerian Hormone Receptor Gene Amhr2
Mol. Cell. Biol., June 15, 2007; 27(12): 4355 - 4364.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. E. Kevenaar, A. P.N. Themmen, J. S.E. Laven, B. Sonntag, S. L. Fong, A. G. Uitterlinden, F. H. de Jong, H. A.P. Pols, M. Simoni, and J. A. Visser
Anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women
Hum. Reprod., June 1, 2007; 22(6): 1547 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
A. L. Marca and A. Volpe
The Anti-Mullerian hormone and ovarian cancer
Hum. Reprod. Update, May 1, 2007; 13(3): 265 - 273.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. A. Visser, A. L. L. Durlinger, I. J. J. Peters, E. R. van den Heuvel, U. M. Rose, P. Kramer, F. H. de Jong, and A. P. N. Themmen
Increased Oocyte Degeneration and Follicular Atresia during the Estrous Cycle in Anti-Mullerian Hormone Null Mice
Endocrinology, May 1, 2007; 148(5): 2301 - 2308.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. H. Thomas, E. E. Telfer, and H. M. Fraser
Expression of Anti-Mullerian Hormone Protein during Early Follicular Development in the Primate Ovary in Vivo Is Influenced by Suppression of Gonadotropin Secretion and Inhibition of Vascular Endothelial Growth Factor
Endocrinology, May 1, 2007; 148(5): 2273 - 2281.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F. J. Diaz, K. Wigglesworth, and J. J. Eppig
Oocytes determine cumulus cell lineage in mouse ovarian follicles
J. Cell Sci., April 15, 2007; 120(8): 1330 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Rice, K. Ojha, S. Whitehead, and H. Mason
Stage-Specific Expression of Androgen Receptor, Follicle-Stimulating Hormone Receptor, and Anti-Mullerian Hormone Type II Receptor in Single, Isolated, Human Preantral Follicles: Relevance to Polycystic Ovaries
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 1034 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
R. A Forsdike, K. Hardy, L. Bull, J. Stark, L. J Webber, S. Stubbs, J. E Robinson, and S. Franks
Disordered follicle development in ovaries of prenatally androgenized ewes
J. Endocrinol., February 1, 2007; 192(2): 421 - 428.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. R. Greenfeld, K. F. Roby, M. E. Pepling, J. K. Babus, P. F. Terranova, and J. A. Flaws
Tumor Necrosis Factor (TNF) Receptor Type 2 Is an Important Mediator of TNF alpha Function in the Mouse Ovary
Biol Reprod, February 1, 2007; 76(2): 224 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Meduri, N. Massin, J. Guibourdenche, A. Bachelot, O. Fiori, F. Kuttenn, M. Misrahi, and P. Touraine
Serum anti-Mullerian hormone expression in women with premature ovarian failure
Hum. Reprod., January 1, 2007; 22(1): 117 - 123.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. Uzumcu, P. E Kuhn, J. E Marano, A. E Armenti, and L. Passantino
Early postnatal methoxychlor exposure inhibits folliculogenesis and stimulates anti-Mullerian hormone production in the rat ovary
J. Endocrinol., December 1, 2006; 191(3): 549 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. La Marca, G. Stabile, A.C. Artenisio, and A. Volpe
Serum anti-Mullerian hormone throughout the human menstrual cycle
Hum. Reprod., December 1, 2006; 21(12): 3103 - 3107.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. Vaccari, S. Latini, M. Barberi, A. Teti, M. Stefanini, and R. Canipari
Characterization and expression of different pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptors in rat ovarian follicles.
J. Endocrinol., October 1, 2006; 191(1): 287 - 299.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws
Ovarian follicle development and transgenic mouse models
Hum. Reprod. Update, September 1, 2006; 12(5): 537 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I.B. Carlsson, J.E. Scott, J.A. Visser, O. Ritvos, A.P.N. Themmen, and O. Hovatta
Anti-Mullerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro
Hum. Reprod., September 1, 2006; 21(9): 2223 - 2227.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
P. G Knight and C. Glister
TGF-{beta} superfamily members and ovarian follicle development.
Reproduction, August 1, 2006; 132(2): 191 - 206.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Sir-Petermann, E. Codner, M. Maliqueo, B. Echiburu, C. Hitschfeld, N. Crisosto, F. Perez-Bravo, S. E. Recabarren, and F. Cassorla
Increased Anti-Mullerian Hormone Serum Concentrations in Prepubertal Daughters of Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3105 - 3109.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. E. Kevenaar, M. F. Meerasahib, P. Kramer, B. M. N. van de Lang-Born, F. H. de Jong, N. P. Groome, A. P. N. Themmen, and J. A. Visser
Serum Anti-Mullerian Hormone Levels Reflect the Size of the Primordial Follicle Pool in Mice
Endocrinology, July 1, 2006; 147(7): 3228 - 3234.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
E. E Nilsson, C. Detzel, and M. K Skinner
Platelet-derived growth factor modulates the primordial to primary follicle transition.
Reproduction, June 1, 2006; 131(6): 1007 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. A. Pangas, X. Li, E. J. Robertson, and M. M. Matzuk
Premature Luteinization and Cumulus Cell Defects in Ovarian-Specific Smad4 Knockout Mice
Mol. Endocrinol., June 1, 2006; 20(6): 1406 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev., April 1, 2006; 27(2): 170 - 207.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
A. Roy and M. M Matzuk
Deconstructing mammalian reproduction: using knockouts to define fertility pathways
Reproduction, February 1, 2006; 131(2): 207 - 219.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
J. A Visser, F. H de Jong, J. S E Laven, and A. P N Themmen
Anti-Mullerian hormone: a new marker for ovarian function
Reproduction, January 1, 2006; 131(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Paredes, C. Garcia-Rudaz, B. Kerr, V. Tapia, G. A. Dissen, M. E. Costa, A. Cornea, and S. R. Ojeda
Loss of Synaptonemal Complex Protein-1, a Synaptonemal Complex Protein, Contributes to the Initiation of Follicular Assembly in the Developing Rat Ovary
Endocrinology, December 1, 2005; 146(12): 5267 - 5277.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
A. La Marca, V. De Leo, S. Giulini, R. Orvieto, S. Malmusi, L. Giannella, and A. Volpe
Anti-Mullerian Hormone in Premenopausal Women and After Spontaneous or Surgically Induced Menopause
Reproductive Sciences, October 1, 2005; 12(7): 545 - 548.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. A. Stubbs, K. Hardy, P. Da Silva-Buttkus, J. Stark, L. J. Webber, A. M. Flanagan, A. P. N. Themmen, J. A. Visser, N. P. Groome, and S. Franks
Anti-Mullerian Hormone Protein Expression Is Reduced during the Initial Stages of Follicle Development in Human Polycystic Ovaries
J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5536 - 5543.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Wang, H. Newton, J. A. Spaliviero, C. M. Allan, B. Marshan, D. J. Handelsman, and P. J. Illingworth
Gonadotropin Control of Inhibin Secretion and the Relationship to Follicle Type and Number in the hpg Mouse
Biol Reprod, October 1, 2005; 73(4): 610 - 618.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
M. K. Skinner
Regulation of primordial follicle assembly and development
Hum. Reprod. Update, September 1, 2005; 11(5): 461 - 471.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
I Demeestere, J Centner, C Gervy, Y Englert, and A Delbaere
Impact of various endocrine and paracrine factors on in vitro culture of preantral follicles in rodents
Reproduction, August 1, 2005; 130(2): 147 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
N. Josso, C. Belville, N. di Clemente, and J.-Y. Picard
AMH and AMH receptor defects in persistent Mullerian duct syndrome
Hum. Reprod. Update, July 1, 2005; 11(4): 351 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
D. Goswami and G. S. Conway
Premature ovarian failure
Hum. Reprod. Update, July 1, 2005; 11(4): 391 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Piltonen, L. Morin-Papunen, R. Koivunen, A. Perheentupa, A. Ruokonen, and J. S. Tapanainen
Serum anti-Mullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome
Hum. Reprod., July 1, 2005; 20(7): 1820 - 1826.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. S. Burns, F. Jimenez-Krassel, J. L.H. Ireland, P. G. Knight, and J. J. Ireland
Numbers of Antral Follicles During Follicular Waves in Cattle: Evidence for High Variation Among Animals, Very High Repeatability in Individuals, and an Inverse Association with Serum Follicle-Stimulating Hormone Concentrations
Biol Reprod, July 1, 2005; 73(1): 54 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. La Marca, S. Giulini, R. Orvieto, V. De Leo, and A. Volpe
Anti-Mullerian hormone concentrations in maternal serum during pregnancy
Hum. Reprod., June 1, 2005; 20(6): 1569 - 1572.
[Abstract] [Full Text] [PDF]

Home page
 J Natl Cancer Inst MonogrHome page
A. P. N. Themmen
Anti-Mullerian Hormone: Its Role in Follicular Growth Initiation and Survival and as an Ovarian Reserve Marker
J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 18 - 21.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. J. Renaud, D. T. MacLaughlin, E. Oliva, B. R. Rueda, and P. K. Donahoe
Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance
PNAS, January 4, 2005; 102(1): 111 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. La Marca, S. Malmusi, S. Giulini, L. F. Tamaro, R. Orvieto, P. Levratti, and A. Volpe
Anti-Mullerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation
Hum. Reprod., December 1, 2004; 19(12): 2738 - 2741.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. L. Britt, P. K. Saunders, S. J. McPherson, M. L. Misso, E. R. Simpson, and J. K. Findlay
Estrogen Actions on Follicle Formation and Early Follicle Development
Biol Reprod, November 1, 2004; 71(5): 1712 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. G.M.G.J. Mulders, J. S.E. Laven, M. J.C. Eijkemans, F. H. de Jong, A. P.N. Themmen, and B. C.J.M. Fauser
Changes in anti-Mullerian hormone serum concentrations over time suggest delayed ovarian ageing in normogonadotrophic anovulatory infertility
Hum. Reprod., September 1, 2004; 19(9): 2036 - 2042.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
K. J. Bodensteiner, H. R. Sawyer, C. L. Moeller, C. M. Kane, K.-Y. F. Pau, G. R. Klinefelter, and D. N. R. Veeramachaneni
Chronic Exposure to Dibromoacetic Acid, a Water Disinfection Byproduct, Diminishes Primordial Follicle Populations in the Rabbit
Toxicol. Sci., July 1, 2004; 80(1): 83 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
W. H. Wallace and T. W. Kelsey
Ovarian reserve and reproductive age may be determined from measurement of ovarian volume by transvaginal sonography
Hum. Reprod., July 1, 2004; 19(7): 1612 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
X. Wu, L. Chen, C. A. Brown, C. Yan, and M. M. Matzuk
Interrelationship of Growth Differentiation Factor 9 and Inhibin in Early Folliculogenesis and Ovarian Tumorigenesis in Mice
Mol. Endocrinol., June 1, 2004; 18(6): 1509 - 1519.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
J. D. Hennebold
Characterization of the ovarian transcriptome through the use of differential analysis of gene expression methodologies
Hum. Reprod. Update, May 1, 2004; 10(3): 227 - 239.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M Myers, K L Britt, N G M Wreford, F J P Ebling, and J B Kerr
Methods for quantifying follicular numbers within the mouse ovary
Reproduction, May 1, 2004; 127(5): 569 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
S. Jonard and D. Dewailly
The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest
Hum. Reprod. Update, March 1, 2004; 10(2): 107 - 117.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. P. Houk, E. J. Pearson, N. Martinelle, P. K. Donahoe, and J. Teixeira
Feedback Inhibition of Steroidogenic Acute Regulatory Protein Expression in Vitro and in Vivo by Androgens
Endocrinology, March 1, 2004; 145(3): 1269 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C. Weenen, J. S.E. Laven, A. R.M. von Bergh, M. Cranfield, N. P. Groome, J. A. Visser, P. Kramer, B. C.J.M. Fauser, and A. P.N. Themmen
Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment
Mol. Hum. Reprod., February 1, 2004; 10(2): 77 - 83.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. S. E. Laven, A. G. M. G. J. Mulders, J. A. Visser, A. P. Themmen, F. H. de Jong, and B. C. J. M. Fauser
Anti-Mullerian Hormone Serum Concentrations in Normoovulatory and Anovulatory Women of Reproductive Age
J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 318 - 323.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. J. Pask, D. J. Whitworth, C.-A. Mao, K.-J. Wei, N. Sankovic, J. A. M. Graves, G. Shaw, M. B. Renfree, and R. R. Behringer
Marsupial Anti-Mullerian Hormone Gene Structure, Regulatory Elements, and Expression
Biol Reprod, January 1, 2004; 70(1): 160 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L.E. Bath, W.H.B. Wallace, M.P. Shaw, C. Fitzpatrick, and R.A. Anderson
Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-Mullerian hormone, inhibin B and ovarian ultrasound
Hum. Reprod., November 1, 2003; 18(11): 2368 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. H. Y. Ng, W. S. B. Yeung, D. Y. T. Fong, and P. C. Ho
Effects of age on hormonal and ultrasound markers of ovarian reserve in Chinese women with proven fertility
Hum. Reprod., October 1, 2003; 18(10): 2169 - 2174.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Hsieh, S. M. Mulders, R. R. Friis, A. Dharmarajan, and J. S. Richards
Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells
Endocrinology, October 1, 2003; 144(10): 4597 - 4606.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
E. E. Nilsson and M. K. Skinner
Bone Morphogenetic Protein-4 Acts as an Ovarian Follicle Survival Factor and Promotes Primordial Follicle Development
Biol Reprod, October 1, 2003; 69(4): 1265 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Balla, N. Danilovich, Y. Yang, and M. R. Sairam
Dynamics of Ovarian Development in the FORKO Immature Mouse: Structural and Functional Implications for Ovarian Reserve
Biol Reprod, October 1, 2003; 69(4): 1281 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Y. Bedecarrats, F. H. O'Neill, E. R. Norwitz, U. B. Kaiser, and J. Teixeira
Regulation of gonadotropin gene expression by Mullerian inhibiting substance
PNAS, August 5, 2003; 100(16): 9348 - 9353.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Kezele and M. K. Skinner
Regulation of Ovarian Primordial Follicle Assembly and Development by Estrogen and Progesterone: Endocrine Model of Follicle Assembly
Endocrinology, August 1, 2003; 144(8): 3329 - 3337.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Misra, D. T. MacLaughlin, P. K. Donahoe, and M. M. Lee
The Role of Mullerian Inhibiting Substance in the Evaluation of Phenotypic Female Patients with Mild Degrees of Virilization
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 787 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Fanchin, L. M. Schonauer, C. Righini, N. Frydman, R. Frydman, and J. Taieb
Serum anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation
Hum. Reprod., February 1, 2003; 18(2): 328 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. Chang, C. W. Brown, and M. M. Matzuk
Genetic Analysis of the Mammalian Transforming Growth Factor-{beta} Superfamily
Endocr. Rev., December 1, 2002; 23(6): 787 - 823.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Mazaud, C. J. Guigon, A. Lozach, N. Coudouel, M. G. Forest, H. Coffigny, and S. Magre
Establishment of the Reproductive Function and Transient Fertility of Female Rats Lacking Primordial Follicle Stock after Fetal {gamma}-Irradiation
Endocrinology, December 1, 2002; 143(12): 4775 - 4787.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I.A.J. van Rooij, F.J.M. Broekmans, E.R. te Velde, B.C.J.M. Fauser, L.F.J.M.M. Bancsi, F.H.d. Jong, and A.P.N. Themmen
Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve
Hum. Reprod., December 1, 2002; 17(12): 3065 - 3071.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society