help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sar, M.
Right arrow Articles by Welsch, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sar, M.
Right arrow Articles by Welsch, F.
Endocrinology Vol. 140, No. 2 963-971
Copyright © 1999 by The Endocrine Society

ARTICLES

Differential Expression of Estrogen Receptor-ß and Estrogen Receptor-{alpha} in the Rat Ovary

Madhabananda Sar and Frank Welsch

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709-2137

Address all correspondence and requests for reprints to: Madhabananda Sar, Ph.D., Chemical Industry Institute of Toxicology, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, North Carolina 27709-2137. E-mail: sar{at}ciit.org

Immunohistochemical localization of two estrogen receptor (ER) subtypes, ERß and ER{alpha}, was performed in neonatal, early postnatal, immature, and adult rats to determine whether ER{alpha} and ERß are differentially expressed in the ovary. ERß and ER{alpha} were visualized using a polyclonal anti-ERß antibody and a monoclonal ER{alpha} (ID5) antibody, respectively. Postfixed frozen sections and antigen-retrieved paraffin sections of the ovary revealed nuclear ERß immunoreactivity (IR) in granulosa cells, which was prevented when peptide-adsorbed antibody was used instead. In immature and adult rat ovaries, ERß was expressed exclusively in nuclei of granulosa cells of primary, secondary, and mature follicles. Atretic follicle granulosa cells showed only weak or no staining. No specific nuclear ERß IR was detected in thecal cells, luteal cells, interstitial cells, germinal epithelium, or oocytes. In neonatal rat ovary, no ERß expression was found. In ovaries of 5- and 10-day-old rats, weak ERß IR was observed in granulosa cells of primary and secondary follicles, but no staining was detected in the primordial follicles. ER{alpha} protein exhibited a differential distribution in the ovary with no detectable expression in the granulosa cells but evidence of ER{alpha} IR in germinal epithelium, interstitial cells, and thecal cells. In the oviduct and uterus, IR for ER{alpha}, but not ERß, was found in luminal epithelium, stromal cells, muscle cells, and gland cells. Our present study demonstrates that ERß and ER{alpha} proteins are expressed in distinctly different cell types in the ovary. The exclusive presence of ERß in granulosa cells implies that this specific new subtype of ERß mediates some effects of estrogen action in the regulation of growth and maturation of ovarian follicles.




This article has been cited by other articles:


Home page
 J Mol EndocrinolHome page
N. Gava, C. L. Clarke, C. Bye, K. Byth, and A. deFazio
Global gene expression profiles of ovarian surface epithelial cells in vivo
J. Mol. Endocrinol., June 1, 2008; 40(6): 281 - 296.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
S. van den Driesche, V. M Smith, M. Myers, and W C. Duncan
Expression and regulation of oestrogen receptors in the human corpus luteum
Reproduction, April 1, 2008; 135(4): 509 - 517.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
K. S. Monkkonen, R. Aflatoonian, K.-F. Lee, W. S.B. Yeung, S.-W. Tsao, J. T. Laitinen, and A. Fazeli
Hormonal regulation of G{alpha}i2 and mPR{alpha} in immortalized human oviductal cell line OE-E6/E7
Mol. Hum. Reprod., December 1, 2007; 13(12): 845 - 851.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Malekinejad, E. J Schoevers, I. J.J.M Daemen, C. Zijlstra, B. Colenbrander, J. Fink-Gremmels, and B. A.J Roelen
Exposure of Oocytes to the Fusarium Toxins Zearalenone and Deoxynivalenol Causes Aneuploidy and Abnormal Embryo Development in Pigs
Biol Reprod, November 1, 2007; 77(5): 840 - 847.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. M Dorward, K. L Shultz, and W. G Beamer
LH analog and dietary isoflavones support ovarian granulosa cell tumor development in a spontaneous mouse model
Endocr. Relat. Cancer, June 1, 2007; 14(2): 369 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Inzunza, A. Morani, G. Cheng, M. Warner, J. Hreinsson, J.-A. Gustafsson, and O. Hovatta
Ovarian wedge resection restores fertility in estrogen receptor beta knockout (ERbeta-/-) mice
PNAS, January 9, 2007; 104(2): 600 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
J. Yeh and B. Kim
Increasing Blunting of Inhibin Responses to Dynamic Ovarian Challenge Is Associated With Reproductive Aging in the Rat
Reproductive Sciences, January 1, 2007; 14(1): 10 - 19.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. M. Kocabas, J. Crosby, P. J. Ross, H. H. Otu, Z. Beyhan, H. Can, W.-L. Tam, G. J. M. Rosa, R. G. Halgren, B. Lim, et al.
The transcriptome of human oocytes
PNAS, September 19, 2006; 103(38): 14027 - 14032.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Titolo, F. Cai, and D. D. Belsham
Coordinate Regulation of Neuropeptide Y and Agouti-Related Peptide Gene Expression by Estrogen Depends on the Ratio of Estrogen Receptor (ER) {alpha} to ER{beta} in Clonal Hypothalamic Neurons
Mol. Endocrinol., September 1, 2006; 20(9): 2080 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. D. Zoma, R. S. Baker, J. L. Mershon, and K. E. Clark
Hemodynamic effects of acute and repeated exposure to raloxifene in ovariectomized sheep
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1216 - H1225.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. F. Couse, M. M. Yates, K. F. Rodriguez, J. A. Johnson, D. Poirier, and K. S. Korach
The Intraovarian Actions of Estrogen Receptor-{alpha} Are Necessary to Repress the Formation of Morphological and Functional Leydig-Like Cells in the Female Gonad
Endocrinology, August 1, 2006; 147(8): 3666 - 3678.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
I. Stavrou, C. Zois, A. Chatzikyriakidou, I. Georgiou, and A. Tsatsoulis
Combined estrogen receptor {alpha} and estrogen receptor beta genotypes influence the age of menarche
Hum. Reprod., February 1, 2006; 21(2): 554 - 557.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W. Jefferson, R. Newbold, E. Padilla-Banks, and M. Pepling
Neonatal Genistein Treatment Alters Ovarian Differentiation in the Mouse: Inhibition of Oocyte Nest Breakdown and Increased Oocyte Survival
Biol Reprod, January 1, 2006; 74(1): 161 - 168.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. F. Couse, M. M. Yates, B. J. Deroo, and K. S. Korach
Estrogen Receptor-{beta} Is Critical to Granulosa Cell Differentiation and the Ovulatory Response to Gonadotropins
Endocrinology, August 1, 2005; 146(8): 3247 - 3262.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
L. J. Spicer
Effects of Estradiol on Bovine Thecal Cell Function In Vitro: Dependence on Insulin and Gonadotropins
J Dairy Sci, July 1, 2005; 88(7): 2412 - 2421.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
C. J. Bowman, K. J. Turner, M. Sar, N. J. Barlow, K. W. Gaido, and P. M. D. Foster
Altered Gene Expression During Rat Wolffian Duct Development following Di(n-Butyl) Phthalate Exposure
Toxicol. Sci., July 1, 2005; 86(1): 161 - 174.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. J. Guigon, N. Coudouel, S. Mazaud-Guittot, M. G. Forest, and S. Magre
Follicular Cells Acquire Sertoli Cell Characteristics after Oocyte Loss
Endocrinology, July 1, 2005; 146(7): 2992 - 3004.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. Liu, K. P. Lehmann, M. Sar, S. S. Young, and K. W. Gaido
Gene Expression Profiling Following In Utero Exposure to Phthalate Esters Reveals New Gene Targets in the Etiology of Testicular Dysgenesis
Biol Reprod, July 1, 2005; 73(1): 180 - 192.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. M. A. Emmen, J. F. Couse, S. A. Elmore, M. M. Yates, G. E. Kissling, and K. S. Korach
In Vitro Growth and Ovulation of Follicles from Ovaries of Estrogen Receptor (ER){alpha} and ER{beta} Null Mice Indicate a Role for ER{beta} in Follicular Maturation
Endocrinology, June 1, 2005; 146(6): 2817 - 2826.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Yang, J. Wang, Y. Shen, and S. K. Roy
Developmental Expression of Estrogen Receptor (ER) {alpha} and ER{beta} in the Hamster Ovary: Regulation by Follicle-Stimulating Hormone
Endocrinology, December 1, 2004; 145(12): 5757 - 5766.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K. L. Britt, P. K. Saunders, S. J. McPherson, M. L. Misso, E. R. Simpson, and J. K. Findlay
Estrogen Actions on Follicle Formation and Early Follicle Development
Biol Reprod, November 1, 2004; 71(5): 1712 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
S Jesmin, C N Mowa, I Sakuma, N Matsuda, H Togashi, M Yoshioka, Y Hattori, and A Kitabatake
Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood
J. Mol. Endocrinol., October 1, 2004; 33(2): 343 - 359.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. F. Couse, M. M. Yates, R. Sanford, A. Nyska, J. H. Nilson, and K. S. Korach
Formation of Cystic Ovarian Follicles Associated with Elevated Luteinizing Hormone Requires Estrogen Receptor-{beta}
Endocrinology, October 1, 2004; 145(10): 4693 - 4702.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
K. P. Lehmann, S. Phillips, M. Sar, P. M. D. Foster, and K. W. Gaido
Dose-Dependent Alterations in Gene Expression and Testosterone Synthesis in the Fetal Testes of Male Rats Exposed to Di (n-butyl) phthalate
Toxicol. Sci., September 1, 2004; 81(1): 60 - 68.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. R. Beker-van Woudenberg, H. T.A. van Tol, B. A.J. Roelen, B. Colenbrander, and M. M. Bevers
Estradiol and Its Membrane-Impermeable Conjugate (Estradiol-Bovine Serum Albumin) During In Vitro Maturation of Bovine Oocytes: Effects on Nuclear and Cytoplasmic Maturation, Cytoskeleton, and Embryo Quality
Biol Reprod, May 1, 2004; 70(5): 1465 - 1474.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Kezele and M. K. Skinner
Regulation of Ovarian Primordial Follicle Assembly and Development by Estrogen and Progesterone: Endocrine Model of Follicle Assembly
Endocrinology, August 1, 2003; 144(8): 3329 - 3337.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. F. Couse, M. M. Yates, V. R. Walker, and K. S. Korach
Characterization of the Hypothalamic-Pituitary-Gonadal Axis in Estrogen Receptor (ER) Null Mice Reveals Hypergonadism and Endocrine Sex Reversal in Females Lacking ER{alpha} But Not ER{beta}
Mol. Endocrinol., June 1, 2003; 17(6): 1039 - 1053.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
N. J. Barlow, S. L. Phillips, D. G. Wallace, M. Sar, K. W. Gaido, and P. M. D. Foster
Quantitative Changes in Gene Expression in Fetal Rat Testes following Exposure to Di(n-butyl) Phthalate
Toxicol. Sci., June 1, 2003; 73(2): 431 - 441.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. J. Jakimiuk, S. R. Weitsman, H.-W. Yen, M. Bogusiewicz, and D. A. Magoffin
Estrogen Receptor {alpha} and {beta} Expression in Theca and Granulosa Cells from Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5532 - 5538.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Jesmin, C. N. Mowa, N. Matsuda, A.-E. Salah-Eldin, H. Togashi, I. Sakuma, Y. Hattori, and A. Kitabatake
Evidence for a Potential Role of Estrogen in the Penis: Detection of Estrogen Receptor-{alpha} and -{beta} Messenger Ribonucleic Acid and Protein
Endocrinology, December 1, 2002; 143(12): 4764 - 4774.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-i. Matsuda, I. Ochiai, M. Nishi, and M. Kawata
Colocalization and Ligand-Dependent Discrete Distribution of the Estrogen Receptor (ER){alpha} and ER{beta}
Mol. Endocrinol., October 1, 2002; 16(10): 2215 - 2230.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W. N. Jefferson, J. F. Couse, E. Padilla-Banks, K. S. Korach, and R. R. Newbold
Neonatal Exposure to Genistein Induces Estrogen Receptor (ER){alpha} Expression and Multioocyte Follicles in the Maturing Mouse Ovary: Evidence for ER{beta}-Mediated and Nonestrogenic Actions
Biol Reprod, October 1, 2002; 67(4): 1285 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, M. D. Sanchez, W. Shea-Eaton, and M. P. McLean
Estrogen Activates the High-Density Lipoprotein Receptor Gene via Binding to Estrogen Response Elements and Interaction with Sterol Regulatory Element Binding Protein-1A
Endocrinology, June 1, 2002; 143(6): 2155 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Yang, A. Kriatchko, and S. K. Roy
Expression of ER-{alpha} and ER-{beta} in the Hamster Ovary: Differential Regulation by Gonadotropins and Ovarian Steroid Hormones
Endocrinology, June 1, 2002; 143(6): 2385 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. M. Klinge, S. C. Jernigan, and K. E. Risinger
The Agonist Activity of Tamoxifen Is Inhibited by the Short Heterodimer Partner Orphan Nuclear Receptor in Human Endometrial Cancer Cells
Endocrinology, March 1, 2002; 143(3): 853 - 867.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
K. A. Brenneman, D. F. Meleason, M. Sar, M. W. Marshall, R. A. James, E. A. Gross, J. T. Martin, and D. C. Dorman
Olfactory Mucosal Necrosis in Male CD Rats Following Acute Inhalation Exposure to Hydrogen Sulfide: Reversibility and the Possible Role of Regional Metabolism
Toxicol Pathol, February 1, 2002; 30(2): 200 - 208.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
Y. Ikeda, A. Nagai, M.-a. Ikeda, and S. Hayashi
Increased Expression of Mullerian-Inhibiting Substance Correlates with Inhibition of Follicular Growth in the Developing Ovary of Rats Treated with E2 Benzoate
Endocrinology, January 1, 2002; 143(1): 304 - 312.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. Cheng, Z. Weihua, S. Makinen, S. Makela, S. Saji, M. Warner, J.-A. Gustafsson, and O. Hovatta
A Role for the Androgen Receptor in Follicular Atresia of Estrogen Receptor Beta Knockout Mouse Ovary
Biol Reprod, January 1, 2002; 66(1): 77 - 84.
[Abstract] [Full Text]

Home page
 Toxicol SciHome page
K. M. Waters, S. Safe, and K. W. Gaido
Differential Gene Expression in Response to Methoxychlor and Estradiol through ER{alpha}, ER{beta}, and AR in Reproductive Tissues of Female Mice
Toxicol. Sci., September 1, 2001; 63(1): 47 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. T. Jansen, C. West, M. N. Lehman, and V. Padmanabhan
Ovarian Estrogen Receptor-{beta} (ER{beta}) Regulation: I. Changes in ER{beta} Messenger RNA Expression Prior to Ovulation in the Ewe
Biol Reprod, September 1, 2001; 65(3): 866 - 872.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Saji, H. Sakaguchi, S. Andersson, M. Warner, and J.-A. Gustafsson
Quantitative Analysis of Estrogen Receptor Proteins in Rat Mammary Gland
Endocrinology, July 1, 2001; 142(7): 3177 - 3186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Signoretti and M. Loda
Estrogen Receptor {beta} in Prostate Cancer : Brake Pedal or Accelerator?
Am. J. Pathol., July 1, 2001; 159(1): 13 - 16.
[Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Cardenas, K.A. Burke, R.M. Bigsby, W.F. Pope, and K.P. Nephew
Estrogen Receptor {beta} in the Sheep Ovary During the Estrous Cycle and Early Pregnancy
Biol Reprod, July 1, 2001; 65(1): 128 - 134.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Guo, L. Savage, K. D. Sarge, and O.-K. Park-Sarge
Gonadotropins Decrease Estrogen Receptor-{beta} Messenger Ribonucleic Acid Stability in Rat Granulosa Cells
Endocrinology, June 1, 2001; 142(6): 2230 - 2237.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K.-C. Choi, S. K. Kang, C.-J. Tai, N. Auersperg, and P. C. K. Leung
Estradiol Up-Regulates Antiapoptotic Bcl-2 Messenger Ribonucleic Acid and Protein in Tumorigenic Ovarian Surface Epithelium Cells
Endocrinology, June 1, 2001; 142(6): 2351 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. K. Kang, K.-C. Choi, C.-J. Tai, N. Auersperg, and P. C. K. Leung
Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells
Endocrinology, February 1, 2001; 142(2): 580 - 588.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. Kurita, K.-j. Lee, P. T.K. Saunders, P. S. Cooke, J. A. Taylor, D. B. Lubahn, C. Zhao, S. Mäkelä, J.-A. Gustafsson, R. Dahiya, et al.
Regulation of Progesterone Receptors and Decidualization in Uterine Stroma of the Estrogen Receptor-{{alpha}} Knockout Mouse
Biol Reprod, January 1, 2001; 64(1): 272 - 283.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Pelletier and M. El-Alfy
Immunocytochemical Localization of Estrogen Receptors {{alpha}} and {beta} in the Human Reproductive Organs
J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4835 - 4840.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
B. Bao, N. Kumar, R. M. Karp, H. Allen Garverick, and K. Sundaram
Estrogen Receptor-{beta} Expression in Relation to the Expression of Luteinizing Hormone Receptor and Cytochrome P450 Enzymes in Rat Ovarian Follicles
Biol Reprod, December 1, 2000; 63(6): 1747 - 1755.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. R. McNeilly, P. T. K. Saunders, M. Taggart, M. Cranfield, H. J. Cooke, and A. S. McNeilly
Loss of Oocytes in Dazl Knockout Mice Results in Maintained Ovarian Steroidogenic Function but Altered Gonadotropin Secretion in Adult Animals
Endocrinology, November 1, 2000; 141(11): 4284 - 4294.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Wang, H. Eriksson, and L. Sahlin
Estrogen Receptors {alpha} and {beta} in the Female Reproductive Tract of the Rat During the Estrous Cycle
Biol Reprod, November 1, 2000; 63(5): 1331 - 1340.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
C.-H. Chiang, K. W. Cheng, S. Igarashi, P. S. Nathwani, and P. C. K. Leung
Hormonal Regulation of Estrogen Receptor {alpha} and {beta} Gene Expression in Human Granulosa-Luteal Cells in Vitro
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3828 - 3839.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
P. T.K. Saunders, M. R. Millar, K. Williams, S. Macpherson, D. Harkiss, R. A. Anderson, B. Orr, N. P. Groome, G. Scobie, and H. M. Fraser
Differential Expression of Estrogen Receptor-{alpha} and -{beta} and Androgen Receptor in the Ovaries of Marmosets and Humans
Biol Reprod, October 1, 2000; 63(4): 1098 - 1105.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. A. Ishunina, F. P. M. Kruijver, R. Balesar, and D. F. Swaab
Differential Expression of Estrogen Receptor {alpha} and {beta} Immunoreactivity in the Human Supraoptic Nucleus in Relation to Sex and Aging
J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3283 - 3291.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
C. Patrone, G. Pollio, E. Vegeto, E. Enmark, I. de Curtis, J.-A. Gustafsson, and A. Maggi
Estradiol Induces Differential Neuronal Phenotypes by Activating Estrogen Receptor {alpha} or {beta}
Endocrinology, May 1, 2000; 141(5): 1839 - 1845.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Chu, P. Mamers, H. G. Burger, and P. J. Fuller
Estrogen Receptor Isoform Gene Expression in Ovarian Stromal and Epithelial Tumors
J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1200 - 1205.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
C. S. Rosenfeld, A. A. Murray, G. Simmer, M. G. Hufford, M. F. Smith, N. Spears, and D. B. Lubahn
Gonadotropin Induction of Ovulation and Corpus Luteum Formation in Young Estrogen Receptor-{alpha} Knockout Mice
Biol Reprod, March 1, 2000; 62(3): 599 - 605.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
W. N. Jefferson, J. F. Couse, E. P. Banks, K. S. Korach, and R. R. Newbold
Expression of Estrogen Receptor {beta} Is Developmentally Regulated in Reproductive Tissues of Male and Female Mice
Biol Reprod, February 1, 2000; 62(2): 310 - 317.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
S Dupont, A Krust, A Gansmuller, A Dierich, P Chambon, and M Mark
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
Development, January 10, 2000; 127(19): 4277 - 4291.
[Abstract] [PDF]

Home page
 ScienceHome page
J. F. Couse, S. C. Hewitt, D. O. Bunch, M. Sar, V. R. Walker, B. J. Davis, and K. S. Korach
Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors  and  
Science, December 17, 1999; 286(5448): 2328 - 2331.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. F. Couse, D. O. Bunch, J. Lindzey, D. W. Schomberg, and K. S. Korach
Prevent