help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Müller, H.
Right arrow Articles by Soares, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Müller, H.
Right arrow Articles by Soares, M. J.
Endocrinology Vol. 140, No. 6 2711-2720
Copyright © 1999 by The Endocrine Society

ARTICLES

Uterine Natural Killer Cells Are Targets for a Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein A1

Heiner Müller2, Bing Liu, B. Anne Croy, Judith R. Head, Joan S. Hunt, Guoli Dai and Michael J. Soares

Departments of Molecular and Integrative Physiology (H.M., B.L., G.D., M.J.S.) and Anatomy and Cell Biology (J.S.H.), University of Kansas Medical Center, Kansas City, Kansas 66160; the Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph (B.A.C.), Guelph, Ontario, Canada N1G 2W1; and the Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center (J.R.H.), Dallas, Texas 75235-9051

Address all correspondence and requests for reprints to: Michael J. Soares, Ph.D., Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 39th and Rainbow Boulevard, Kansas City, Kansas 66160. E-mail: msoares{at}kumc.edu

PRL-like protein A (PLP-A) is a member of the PRL family expressed in trophoblast cells coincident with establishment of the chorioallantoic placenta. The purpose of this investigation was to identify targets for PLP-A. Using an alkaline phosphatase-tagging strategy, we show that PLP-A specifically interacts with a population of natural killer (NK) lymphocytes within the mesometrial compartment of decidua from pregnant and pseudopregnant rats. These observations are supported by the codistribution of PLP-A targets with cells expressing the rat NK cell surface marker, gp42, the absence of PLP-A binding in conceptuses from NK cell-deficient tg{epsilon}26 mice, and the specific interaction of PLP-A with a rat NK cell line, RNK-16. We have further demonstrated that PLP-A effectively suppresses RNK-16 cell cytolytic activities. Our results provide evidence for a new paradigm of embryonic-maternal communication involving a PLP-A signaling pathway between trophoblast cells and uterine NK lymphocytes.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. M. K. Alam, T. Konno, N. Sahgal, L. Lu, and M. J. Soares
Decidual Cells Produce a Heparin-binding Prolactin Family Cytokine with Putative Intrauterine Regulatory Actions
J. Biol. Chem., July 4, 2008; 283(27): 18957 - 18968.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. L. Herington and B. M. Bany
Effect of the Conceptus on Uterine Natural Killer Cell Numbers and Function in the Mouse Uterus During Decidualization
Biol Reprod, April 1, 2007; 76(4): 579 - 588.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. M. K. Alam, T. Konno, G. Dai, L. Lu, D. Wang, J. H. Dunmore, A. R. Godwin, and M. J. Soares
A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor
Development, January 15, 2007; 134(2): 407 - 415.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. Tayade, Y. Fang, G. P. Black, P. VA Jr, A. Erlebacher, and B. A. Croy
Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells
J. Leukoc. Biol., December 1, 2005; 78(6): 1347 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. Dosiou and L. C. Giudice
Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives
Endocr. Rev., February 1, 2005; 26(1): 44 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Green
Defining the function of a prolactin gene family member
PNAS, November 23, 2004; 101(47): 16397 - 16398.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Ain, G. Dai, J. H. Dunmore, A. R. Godwin, and M. J. Soares
From the Cover: A prolactin family paralog regulates reproductive adaptations to a physiological stressor
PNAS, November 23, 2004; 101(47): 16543 - 16548.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
D. Jaquemar, S. Kupriyanov, M. Wankell, J. Avis, K. Benirschke, H. Baribault, and R. G. Oshima
Keratin 8 protection of placental barrier function
J. Cell Biol., May 26, 2003; 161(4): 749 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Kamei, S. R. Jones, B. M. Chapman, K. L. MCGonigle, G. Dai, and M. J. Soares
The Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Modulates the Endocrine Differentiation of Trophoblast Cells
Mol. Endocrinol., July 1, 2002; 16(7): 1469 - 1481.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
L.-Y. Yu-Lee
Prolactin Modulation of Immune and Inflammatory Responses
Recent Prog. Horm. Res., January 1, 2002; 57(1): 435 - 455.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. J. Toft, S. B. Rosenberg, G. Bergers, O. Volpert, and D. I. H. Linzer
Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression
PNAS, October 16, 2001; (2001) 231364798.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. W. Losordo and J. M. Isner
Estrogen and Angiogenesis : A Review
Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 6 - 12.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. J. Toft and D. I.H. Linzer
Identification of Three Prolactin-Related Hormones as Markers of Invasive Trophoblasts in the Rat
Biol Reprod, August 1, 2000; 63(2): 519 - 525.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
G. T. Ma and D. I.H. Linzer
GATA-2 Restricts Prolactin-Like Protein A Expression to Secondary Trophoblast Giant Cells in the Mouse
Biol Reprod, August 1, 2000; 63(2): 570 - 574.
[Abstract] [Full Text]

Home page
 JEMHome page
R. W. Redline
Role of Uterine Natural Killer Cells and Interferon {gamma} in Placental Development
J. Exp. Med., July 18, 2000; 192(2): F1 - F4.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Toft and D. I. H. Linzer
Prolactin (PRL)-Like Protein J, a Novel Member of the PRL/Growth Hormone Family, Is Exclusively Expressed in Maternal Decidua
Endocrinology, November 1, 1999; 140(11): 5095 - 5101.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
G. Dai, M. W. Wolfe, and M. J. Soares
Distinct Regulatory Regions from the Prolactin-Like Protein C Variant Promoter Direct Trophoblast Giant Cell Versus Spongiotrophoblast Cell-Specific Expression
Endocrinology, October 1, 1999; 140(10): 4691 - 4698.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. Lin and D. I. H. Linzer
Induction of Megakaryocyte Differentiation by a Novel Pregnancy-specific Hormone
J. Biol. Chem., July 23, 1999; 274(30): 21485 - 21489.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. J. Toft, S. B. Rosenberg, G. Bergers, O. Volpert, and D. I. H. Linzer
Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression
PNAS, November 6, 2001; 98(23): 13055 - 13059.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society