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Endocrinology Vol. 140, No. 6 2711-2720
Copyright © 1999 by The Endocrine Society

ARTICLES

Uterine Natural Killer Cells Are Targets for a Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein A1

Heiner Müller2, Bing Liu, B. Anne Croy, Judith R. Head, Joan S. Hunt, Guoli Dai and Michael J. Soares

Departments of Molecular and Integrative Physiology (H.M., B.L., G.D., M.J.S.) and Anatomy and Cell Biology (J.S.H.), University of Kansas Medical Center, Kansas City, Kansas 66160; the Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph (B.A.C.), Guelph, Ontario, Canada N1G 2W1; and the Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center (J.R.H.), Dallas, Texas 75235-9051

Address all correspondence and requests for reprints to: Michael J. Soares, Ph.D., Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 39th and Rainbow Boulevard, Kansas City, Kansas 66160. E-mail: msoares{at}kumc.edu

PRL-like protein A (PLP-A) is a member of the PRL family expressed in trophoblast cells coincident with establishment of the chorioallantoic placenta. The purpose of this investigation was to identify targets for PLP-A. Using an alkaline phosphatase-tagging strategy, we show that PLP-A specifically interacts with a population of natural killer (NK) lymphocytes within the mesometrial compartment of decidua from pregnant and pseudopregnant rats. These observations are supported by the codistribution of PLP-A targets with cells expressing the rat NK cell surface marker, gp42, the absence of PLP-A binding in conceptuses from NK cell-deficient tg{epsilon}26 mice, and the specific interaction of PLP-A with a rat NK cell line, RNK-16. We have further demonstrated that PLP-A effectively suppresses RNK-16 cell cytolytic activities. Our results provide evidence for a new paradigm of embryonic-maternal communication involving a PLP-A signaling pathway between trophoblast cells and uterine NK lymphocytes.




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