This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhang, Q. Articles by Wolgemuth, D. J. Search for Related Content PubMed PubMed Citation Articles by Zhang, Q. Articles by Wolgemuth, D. J.

Developmentally Regulated Expression of Cyclin D3 and Its Potential in Vivo Interacting Proteins during Murine Gametogenesis¹

Departments of Genetics and Development (D.J.W.) and Obstetrics and Gynecology (D.J.W.), Center for Reproductive Sciences (Q.Z., X.W., D.J.W.), The Herbert Irving Comprehensive Cancer Center (D.J.W.), and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons (D.J.W.), New York, New York 10032

Address all correspondence and requests for reprints to: Debra J. Wolgemuth, Ph.D., Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032. E-mail: djw3{at}columbia.edu

To begin to assess the function of the cell cycle regulator cyclin D3 during gametogenesis, the present study examined its expression, interacting partners, and associated kinase activity in the murine testis and ovary. In the early stages of postnatal testicular development, cyclin D3 protein was detected in spermatogonia and Leydig cells. In the adult testis, cyclin D3 was also expressed in terminally differentiating spermatids. In the embryonic ovary, detection of cyclin D3 was limited to somatic cells. In the postnatal ovary, its localization was predominantly in the nuclei of oocytes in primordial and small follicles, a localization that diminished with oocyte growth. Cdk4 and p27 were expressed in a similar subset of testicular and ovarian cells, suggesting that they may regulate cyclin D3 function during testicular and ovarian development in a cell type-specific manner. Cyclin D3-associated kinase activity was detected in immature, but not adult, testes and ovaries. These observations suggest unique roles for cyclin D3 in the control of cell division and differentiation in the germ line and the differential regulation of mitotic and meiotic cell cycles during male and female gametogenesis.

This article has been cited by other articles:

				E. Shang, H. D. Nickerson, D. Wen, X. Wang, and D. J. Wolgemuth The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation Development, October 1, 2007; 134(19): 3507 - 3515. [Abstract] [Full Text] [PDF]

				J. Fombonne, C. Charrier, I. Goddard, E. Moyse, and S. Krantic Leptin-Mediated Decrease of Cyclin A2 and Increase of Cyclin D1 Expression: Relevance for the Control of Prepubertal Rat Leydig Cell Division and Differentiation Endocrinology, May 1, 2007; 148(5): 2126 - 2137. [Abstract] [Full Text] [PDF]

				L. Liu, S. Rajareddy, P. Reddy, C. Du, K. Jagarlamudi, Y. Shen, D. Gunnarsson, G. Selstam, K. Boman, and K. Liu Infertility caused by retardation of follicular development in mice with oocyte-specific expression of Foxo3a Development, January 1, 2007; 134(1): 199 - 209. [Abstract] [Full Text] [PDF]

				C. Ottolenghi, S. Omari, J. E. Garcia-Ortiz, M. Uda, L. Crisponi, A. Forabosco, G. Pilia, and D. Schlessinger Foxl2 is required for commitment to ovary differentiation Hum. Mol. Genet., July 15, 2005; 14(14): 2053 - 2062. [Abstract] [Full Text] [PDF]

				J. Kohoutek, P. Dvorak, and A. Hampl Temporal Distribution of CDK4, CDK6, D-Type Cyclins, and p27 in Developing Mouse Oocytes Biol Reprod, January 1, 2004; 70(1): 139 - 145. [Abstract] [Full Text] [PDF]

				T. E. Crowley, E. M. Kaine, M. Yoshida, A. Nandi, and D. J. Wolgemuth Reproductive Cycle Regulation of Nuclear Import, Euchromatic Localization, and Association with Components of Pol II Mediator of a Mammalian Double-Bromodomain Protein Mol. Endocrinol., August 1, 2002; 16(8): 1727 - 1737. [Abstract] [Full Text] [PDF]

				S. Dolci, M. Pellegrini, S. Di Agostino, R. Geremia, and P. Rossi Signaling through Extracellular Signal-regulated Kinase Is Required for Spermatogonial Proliferative Response to Stem Cell Factor J. Biol. Chem., October 19, 2001; 276(43): 40225 - 40233. [Abstract] [Full Text] [PDF]

				F. Zindy, W. den Besten, B. Chen, J. E. Rehg, E. Latres, M. Barbacid, J. W. Pollard, C. J. Sherr, P. E. Cohen, and M. F. Roussel Control of Spermatogenesis in Mice by the Cyclin D-Dependent Kinase Inhibitors p18Ink4c and p19Ink4d Mol. Cell. Biol., May 1, 2001; 21(9): 3244 - 3255. [Abstract] [Full Text]

				T. L. Beumer, H. L. Roepers-Gajadien, I. S. Gademan, H. B. Kal, and D. G. de Rooij Involvement of the D-Type Cyclins in Germ Cell Proliferation and Differentiation in the Mouse Biol Reprod, December 1, 2000; 63(6): 1893 - 1898. [Abstract] [Full Text]

				L.-X. Feng, N. Ravindranath, and M. Dym Stem Cell Factor/c-kit Up-regulates Cyclin D3 and Promotes Cell Cycle Progression via the Phosphoinositide 3-Kinase/p70 S6 Kinase Pathway in Spermatogonia J. Biol. Chem., August 11, 2000; 275(33): 25572 - 25576. [Abstract] [Full Text] [PDF]