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Mammary Type I Deiodinase Is Dependent on the Suckling Stimulus: Differential Role of Norepinephrine and Prolactin¹

Departamento de Neuroendocrinología, Centro de Neurobiología, Campus Juriquilla, Queretaro, Qro. 76001; and Departamento de Fisiología, Facultad de Medicina, Ciudad Universitaria, Mexico DF 04510, UNAM Mexico

Address all correspondence and requests for reprints to: Dr. Carmen Aceves, Departamento de Neuroendocrinología, Centro de Neurobiología, Campus Juriquilla, UNAM, Apartado Postal 1–1141, Queretaro, Qro. 76001, Mexico. E-mail: caracev{at}servidor.unam.mx

Mammary deiodinase type I (M-D1) is present only during lactation and exhibits a clear direct correlation with lactation intensity (size of litters). The present work shows that M-D1 is suckling dependent and that intervals between suckling periods no longer than 12 h are essential to maintain this activity. Moreover, we find that with only 15 min of resuckling in 12-h nonsuckled mothers, the 50% decrease in both M-D1 messenger RNA and enzymatic activity could be restored to control values. This restorative effect by suckling may involve pre- and posttranscriptional mechanisms in which norepinephrine and PRL play important roles. Norepinephrine elicits a potent stimulatory effect on M-D1 messenger RNA and enzyme activities, whereas PRL only increases M-D1 activity and may modulate the enzyme response to norepinephrine. Oxytocin and GH had no effect. These data suggest that the adrenergic nervous system and PRL could directly participate in mammary energetic expenditure, regulating the local T₃ supply.

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