| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ARTICLES |
Unité de Diabétologie et Nutrition, Université Catholique de Louvain, B-1200 Brussels, Belgium; U-376, INSERM, Hopital Arnaud de Villneuve (A.L.C.), 34295 Montpellier, France; and U-344, INSERM, Hôpital Necker (M.E.), 75730 Paris, France
Address all correspondence and requests for reprints to: Jean-Paul Thissen, M.D., Diabetes and Nutrition Unit, avenue Hippocrate 54, 1200 Brussels, Belgium. E-mail: thissen{at}diab.ucl.ac.be
Endotoxin and proinflammatory cytokines such as interleukin-1ß
(IL-1ß) and tumor necrosis factor-
(TNF) induce a state of GH
resistance. A new family of suppressors of cytokine signaling (SOCS),
induced by cytokines activating the Janus kinase (JAK)-signal
transducer and activator of transcription (STAT) pathway, has been
recently identified as a negative feedback loop of intracellular
signaling. Overexpression of some SOCS (SOCS-3, CIS, and SOCS-2) has
been reported to inhibit the JAK-STAT pathway stimulated by GH. To
assess the possible role of these three SOCS proteins in the GH
resistance induced by endotoxin and cytokines, we investigated the
regulation of their gene expression by endotoxin and GH in rat liver
and by proinflammatory cytokines and GH in primary culture hepatocytes.
Both GH and lipopolysaccharide induced the three SOCS messenger RNAs
(mRNAs) in vivo. In vitro, GH also
increased the liver mRNAs encoding SOCS-2, SOCS-3, and CIS. Although
IL-1ß and TNF alone induced only weakly the expression of SOCS-3
and CIS, these cytokines strongly potentiated the induction of these
two SOCS by GH. In contrast, IL-6 alone markedly induced SOCS-3 mRNA,
but did not potentiate the GH action on SOCS-3 and CIS mRNAs. The GH
induction of SOCS-2 was not potentiated by any of these cytokines.
Considering the ability of these SOCS to inhibit the JAK-STAT pathway
induced by GH, these results suggest that the overexpression of SOCS-3
and CIS mRNAs induced by IL-1ß and TNF or by endotoxin in
vivo may play a role in the GH resistance induced by sepsis.
This article has been cited by other articles:
 |
|
 |
|
  X. Wang, J. Jiang, J. Warram, G. Baumann, Y. Gan, R. K. Menon, L. A. Denson, K. R. Zinn, and S. J. Frank Endotoxin-Induced Proteolytic Reduction in Hepatic Growth Hormone (GH) Receptor: A Novel Mechanism for GH Insensitivity Mol. Endocrinol., June 1, 2008; 22(6): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Elsasser, T. J. Caperna, C-J. Li, S. Kahl, and J. L. Sartin Critical control points in the impact of the proinflammatory immune response on growth and metabolism J Anim Sci, April 1, 2008; 86(14_suppl): E105 - E125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Winkelman, M. C. Lucy, T. H. Elsasser, J. L. Pate, and C. K. Reynolds Short Communication: Suppressor of Cytokine Signaling-2 mRNA Increases After Parturition in the Liver of Dairy Cows J Dairy Sci, March 1, 2008; 91(3): 1080 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R P Rhoads, J W Kim, M E Van Amburgh, R A Ehrhardt, S J Frank, and Y R Boisclair Effect of nutrition on the GH responsiveness of liver and adipose tissue in dairy cows J. Endocrinol., October 1, 2007; 195(1): 49 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Elsasser, S. Kahl, C.-J. Li, J. L. Sartin, W. M. Garrett, and J. Rodrigo Caveolae Nitration of Janus Kinase-2 at the 1007Y-1008Y Site: Coordinating Inflammatory Response and Metabolic Hormone Readjustment within the Somatotropic Axis Endocrinology, August 1, 2007; 148(8): 3803 - 3813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, D. Sun, V. M. R. Krishnamurthy, and R. Rabkin Endotoxin attenuates growth hormone-induced hepatic insulin-like growth factor I expression by inhibiting JAK2/STAT5 signal transduction and STAT5b DNA binding Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1856 - E1862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Shumate, G. Yumet, T. A. Ahmed, and R. N. Cooney Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G227 - G239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Leong, S. Moverare, J. Brce, N. Doyle, K. Sjogren, K. Dahlman-Wright, J.-A. Gustafsson, K. K. Y. Ho, C. Ohlsson, and K.-C. Leung Estrogen Up-Regulates Hepatic Expression of Suppressors of Cytokine Signaling-2 and -3 in Vivo and in Vitro Endocrinology, December 1, 2004; 145(12): 5525 - 5531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-C. Leung, G. Johannsson, G. M. Leong, and K. K. Y. Ho Estrogen Regulation of Growth Hormone Action Endocr. Rev., October 1, 2004; 25(5): 693 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Q. Hong-Brown, C. R. Brown, R. N. Cooney, R. A. Frost, and C. H. Lang Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E63 - E72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Frost, G. J. Nystrom, and C. H. Lang Tumor Necrosis Factor-{alpha} Decreases Insulin-Like Growth Factor-I Messenger Ribonucleic Acid Expression in C2C12 Myoblasts via a Jun N-Terminal Kinase Pathway Endocrinology, May 1, 2003; 144(5): 1770 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Senn, P. J. Klover, I. A. Nowak, T. A. Zimmers, L. G. Koniaris, R. W. Furlanetto, and R. A. Mooney Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes J. Biol. Chem., April 11, 2003; 278(16): 13740 - 13746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Denson, M. A. Held, R. K. Menon, S. J. Frank, A. F. Parlow, and D. L. Arnold Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3 Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G646 - G654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rui, M. Yuan, D. Frantz, S. Shoelson, and M. F. White SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2 J. Biol. Chem., October 25, 2002; 277(44): 42394 - 42398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-E. Kong, S. M. Firth, R. C. Baxter, and P. J. D. Delhanty Regulation of the acid-labile subunit in sustained endotoxemia Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E692 - E701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Ronn, J. A. Hansen, K. Lindberg, A. E. Karlsen, and N. Billestrup The Effect of Suppressor of Cytokine Signaling 3 on GH Signaling in {beta}-Cells Mol. Endocrinol., September 1, 2002; 16(9): 2124 - 2134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Yumet, M. L. Shumate, P. Bryant, C.-M. Lin, C. H. Lang, and R. N. Cooney Tumor necrosis factor mediates hepatic growth hormone resistance during sepsis Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E472 - E481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Beauloye, B. Willems, V. de Coninck, S. J. Frank, M. Edery, and J.-P. Thissen Impairment of Liver GH Receptor Signaling by Fasting Endocrinology, March 1, 2002; 143(3): 792 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ling and H. Billig PRL Receptor-Mediated Effects in Female Mouse Adipocytes: PRL Induces Suppressors of Cytokine Signaling Expression and Suppresses Insulin-Induced Leptin Production in Adipocytes in Vitro Endocrinology, November 1, 2001; 142(11): 4880 - 4890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Mooney, J. Senn, S. Cameron, N. Inamdar, L. M. Boivin, Y. Shang, and R. W. Furlanetto Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor. A POTENTIAL MECHANISM FOR CYTOKINE-MEDIATED INSULIN RESISTANCE J. Biol. Chem., July 6, 2001; 276(28): 25889 - 25893. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
