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Endocrinology Vol. 141, No. 12 4503-4511
Copyright © 2000 by The Endocrine Society

ARTICLES

A Role for Akt in Mediating the Estrogenic Functions of Epidermal Growth Factor and Insulin-Like Growth Factor I1

Mary Beth Martin, Thomas F. Franke, Gerald E. Stoica, Pierre Chambon, Benita S. Katzenellenbogen, Bogdan A. Stoica, Michael S. McLemore, Susan E. Olivo and Adriana Stoica

Department of Oncology (M.B.M., G.E.S., M.S.M., S.E.O., A.S.), Lombardi Cancer Center, Georgetown University, Washington, DC 20007; Department of Biochemistry and Molecular Biology (M.B.M., A.S.), Lombardi Cancer Center, Georgetown University, Washington, DC 20007; Department of Pharmacology (T.F.F.), Columbia University, New York 10032; Institut de Genetique et de Biologie Moleculaire et Cellulaire (P.C.), CNRS/INSERM/ULP, College de France, BP 163 163,67404 Illkirch Cedex, France; Department of Molecular and Integrative Physiology (B.S.K.), University of Illinois, Urbana, Illinois 61801; and Department of Neuroscience (B.S.), Georgetown University, Washington, DC 20007

Address all correspondence and requests for reprints to: Adriana Stoica, Lombardi Cancer Center, E411 Research Building, 3970 Reservoir Road NW, Washington, DC 20007. E-mail: stoicaa{at}gunet.georgetown.edu

This study examines whether the serine/threonine protein kinase, Akt, is involved in the cross-talk between epidermal growth factor (EGF) and insulin-related growth factor I (IGF-I) receptors and ER-{alpha}. Treatment of MCF-7 cells with either EGF or IGF-I resulted in a rapid phosphorylation of Akt and a 14- to 16-fold increase in Akt activity, respectively. Akt activation was blocked by inhibitors of phosphatidylinositol 3-kinase, but not by an inhibitor of the ribosomal protein kinase p70S6K. Stable transfection of cells with a dominant negative Akt mutant blocked the effects of EGF and IGF-I on ER-{alpha} expression and activity, whereas stable transfection of cells with a constitutively active Akt mutant mimicked the effects of EGF and IGF-I. In the latter cells, there was a decrease in the amount of ER-{alpha} protein and messenger RNA (70–80%) and an increase in the amount of progesterone receptor protein, messenger RNA (4- to 9- and by 3.5- to 7-fold, respectively) and pS2 (3- to 5-fold). Coexpression of wild-type ER-{alpha} and the dominant negative Akt mutant in COS-1 cells also blocked the growth factor-stimulated activation of ER-{alpha}, but coexpression of the wild-type receptor with the constitutively active Akt mutant increased ER-{alpha} activity. Receptor activation was blocked by an antiestrogen. Studies using mutants of ER-{alpha} demonstrated that Akt increased estrogen receptor activity through the amino-terminal activation function-1 (AF-1). Serines S104 S106, S118, and S167 appear to play a role in the activation of ER-{alpha} by Akt.




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Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Proximal Events in Signaling by Plasma Membrane Estrogen Receptors
J. Biol. Chem., January 17, 2003; 278(4): 2701 - 2712.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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J. Nutr., November 1, 2002; 132(11): 3482S - 3489.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., March 1, 2002; 277(10): 8531 - 8537.
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Home page
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Home page
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