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Endocrinology Vol. 141, No. 2 772-778
Copyright © 2000 by The Endocrine Society

ARTICLES

Expression of Mouse 17ß-Hydroxysteroid Dehydrogenase/17-Ketosteroid Reductase Type 7 in the Ovary, Uterus, and Placenta: Localization from Implantation to Late Pregnancy1

Pasi Nokelainen, Hellevi Peltoketo, Mika Mustonen2 and Pirkko Vihko

Biocenter Oulu and World Health Organization Collaborating Center for Research on Reproductive Health, University of Oulu (P.N., H.P., M.M., P.V.), FIN-90014 Oulu; and the Department of Biosciences, Division of Biochemistry, University of Helsinki (P.V.), FIN-90014 Helsinki, Finland

Address all correspondence and requests for reprints to: Prof. Pirkko Vihko, Biocenter Oulu and World Health Organization Collaborating Center for Research on Reproductive Health, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland. E-mail: pvihko@whoccr.oulu.fi or pirkko.vihko{at}helsinki.fi

Rodent 17ß-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 (17HSD/KSR7) catalyzes the conversion of estrone (E1) to estradiol (E2) and is abundantly expressed in the ovaries of pregnant animals in particular. In the present work we demonstrate cell-specific expression of 17HSD/KSR7 in the ovaries, uteri, and placentas of pregnant and nonpregnant mice using in situ hybridization.

The results show that mouse 17HSD/KSR7 (m17HSD/KSR7) messenger RNA is distinctly and exclusively expressed in a proportion of corpora lutea (CLs). During pregnancy, expression of m17HSD/KSR7 is most abundant around embryonic day 14.5 (E14.5), when the ovaries are filled with CLs expressing 17HSD/KSR7. In the uterus, m17HSD/KSR7 is first detected on E5.5, when expression surrounds the implantation site on the antimesometrial side. As gestation progresses, m17HSD/KSR7 is expressed in the decidua capsularis on E8 and E9.5, disappearing thereafter from the antimesometrial decidua. On E9 onward, m17HSD/KSR7 messenger RNA expression takes place at the junctional zone of the developing placenta. On E12.5 and E14.5, m17HSD/KSR7 is abundantly expressed in the spongiotrophoblasts, where expression gradually declines toward parturition.

In conclusion, m17HSD/KSR7 expression in the CL is related to the life span of the CL. Moreover, spatial and temporal expression of m17HSD/KSR7 in the uterus suggests that locally produced E2 plays a role in implantation and/or decidualization. Finally, the results indicate that mouse placenta is capable of converting E1 to E2 in situ, and that the synthesized E2 may be effective in a paracrine, autocrine, and/or intracrine manner and be involved in placentation.




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