help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nokelainen, P.
Right arrow Articles by Vihko, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nokelainen, P.
Right arrow Articles by Vihko, P.
Endocrinology Vol. 141, No. 2 772-778
Copyright © 2000 by The Endocrine Society

ARTICLES

Expression of Mouse 17ß-Hydroxysteroid Dehydrogenase/17-Ketosteroid Reductase Type 7 in the Ovary, Uterus, and Placenta: Localization from Implantation to Late Pregnancy1

Pasi Nokelainen, Hellevi Peltoketo, Mika Mustonen2 and Pirkko Vihko

Biocenter Oulu and World Health Organization Collaborating Center for Research on Reproductive Health, University of Oulu (P.N., H.P., M.M., P.V.), FIN-90014 Oulu; and the Department of Biosciences, Division of Biochemistry, University of Helsinki (P.V.), FIN-90014 Helsinki, Finland

Address all correspondence and requests for reprints to: Prof. Pirkko Vihko, Biocenter Oulu and World Health Organization Collaborating Center for Research on Reproductive Health, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland. E-mail: pvihko@whoccr.oulu.fi or pirkko.vihko{at}helsinki.fi

Rodent 17ß-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 (17HSD/KSR7) catalyzes the conversion of estrone (E1) to estradiol (E2) and is abundantly expressed in the ovaries of pregnant animals in particular. In the present work we demonstrate cell-specific expression of 17HSD/KSR7 in the ovaries, uteri, and placentas of pregnant and nonpregnant mice using in situ hybridization.

The results show that mouse 17HSD/KSR7 (m17HSD/KSR7) messenger RNA is distinctly and exclusively expressed in a proportion of corpora lutea (CLs). During pregnancy, expression of m17HSD/KSR7 is most abundant around embryonic day 14.5 (E14.5), when the ovaries are filled with CLs expressing 17HSD/KSR7. In the uterus, m17HSD/KSR7 is first detected on E5.5, when expression surrounds the implantation site on the antimesometrial side. As gestation progresses, m17HSD/KSR7 is expressed in the decidua capsularis on E8 and E9.5, disappearing thereafter from the antimesometrial decidua. On E9 onward, m17HSD/KSR7 messenger RNA expression takes place at the junctional zone of the developing placenta. On E12.5 and E14.5, m17HSD/KSR7 is abundantly expressed in the spongiotrophoblasts, where expression gradually declines toward parturition.

In conclusion, m17HSD/KSR7 expression in the CL is related to the life span of the CL. Moreover, spatial and temporal expression of m17HSD/KSR7 in the uterus suggests that locally produced E2 plays a role in implantation and/or decidualization. Finally, the results indicate that mouse placenta is capable of converting E1 to E2 in situ, and that the synthesized E2 may be effective in a paracrine, autocrine, and/or intracrine manner and be involved in placentation.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Das, S. R. Mantena, A. Kannan, D. B. Evans, M. K. Bagchi, and I. C. Bagchi
De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis
PNAS, July 28, 2009; 106(30): 12542 - 12547.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. S. Devi, A. Shehu, C. Stocco, J. Halperin, J. Le, A. M. Seibold, M. Lahav, N. Binart, and G. Gibori
Regulation of Transcription Factors and Repression of Sp1 by Prolactin Signaling Through the Short Isoform of Its Cognate Receptor
Endocrinology, July 1, 2009; 150(7): 3327 - 3335.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Shehu, J. Mao, G. B. Gibori, J. Halperin, J. Le, Y. Sangeeta Devi, B. Merrill, H. Kiyokawa, and G. Gibori
Prolactin Receptor-Associated Protein/17{beta}-Hydroxysteroid Dehydrogenase Type 7 Gene (Hsd17b7) Plays a Crucial Role in Embryonic Development and Fetal Survival
Mol. Endocrinol., October 1, 2008; 22(10): 2268 - 2277.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
T. Ohnesorg, B. Keller, M. H. de Angelis, and J. Adamski
Transcriptional regulation of human and murine 17{beta}-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.
J. Mol. Endocrinol., August 1, 2006; 37(1): 185 - 197.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. F. Couse, M. M. Yates, B. J. Deroo, and K. S. Korach
Estrogen Receptor-{beta} Is Critical to Granulosa Cell Differentiation and the Ovulatory Response to Gonadotropins
Endocrinology, August 1, 2005; 146(8): 3247 - 3262.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. E. Vaskivuo, M. Maentausta, S. Torn, O. Oduwole, A. Lonnberg, R. Herva, V. Isomaa, and J. S. Tapanainen
Estrogen Receptors and Estrogen-Metabolizing Enzymes in Human Ovaries during Fetal Development
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3752 - 3756.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Risk, A. Shehu, J. Mao, C. O. Stocco, L. T. Goldsmith, J. M. Bowen-Shauver, and G. Gibori
Cloning and Characterization of a 5' Regulatory Region of the Prolactin Receptor-Associated Protein/17{beta} Hydroxysteroid Dehydrogenase 7 Gene
Endocrinology, June 1, 2005; 146(6): 2807 - 2816.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Foyouzi, Z. Cai, Y. Sugimoto, and C. Stocco
Changes in the Expression of Steroidogenic and Antioxidant Genes in the Mouse Corpus Luteum During Luteolysis
Biol Reprod, May 1, 2005; 72(5): 1134 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. H. Payne and D. B. Hales
Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Endocr. Rev., December 1, 2004; 25(6): 947 - 970.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. F. Couse, M. M. Yates, R. Sanford, A. Nyska, J. H. Nilson, and K. S. Korach
Formation of Cystic Ovarian Follicles Associated with Elevated Luteinizing Hormone Requires Estrogen Receptor-{beta}
Endocrinology, October 1, 2004; 145(10): 4693 - 4702.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Z. Marijanovic, D. Laubner, G. Moller, C. Gege, B. Husen, J. Adamski, and R. Breitling
Closing the Gap: Identification of Human 3-Ketosteroid Reductase, the Last Unknown Enzyme of Mammalian Cholesterol Biosynthesis
Mol. Endocrinol., September 1, 2003; 17(9): 1715 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
B. Husen, J. Adamski, A. Bruns, D. Deluca, K. Fuhrmann, G. Moller, I. Schwabe, and A. Einspanier
Characterization of 17{beta}-Hydroxysteroid Dehydrogenase Type 7 in Reproductive Tissues of the Marmoset Monkey
Biol Reprod, June 1, 2003; 68(6): 2092 - 2099.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Leonardsson, M. A. Jacobs, R. White, R. Jeffery, R. Poulsom, S. Milligan, and M. Parker
Embryo Transfer Experiments and Ovarian Transplantation Identify the Ovary as the Only Site in Which Nuclear Receptor Interacting Protein 1/RIP140 Action Is Crucial for Female Fertility
Endocrinology, February 1, 2002; 143(2): 700 - 707.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society