| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ARTICLES |
Prince Henry’s Institute of Medical Research (J.I., S.P., I.J.C.), Clayton, Victoria 3168, Australia; and Department of Medicine (R.V.C.), Indiana University, Indianapolis, Indiana 46202
Address all correspondence and requests for reprints to: Professor Iain J. Clarke, Prince Henry’s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia. E-mail: iain.clarke{at}med monash.
Leptin is a secreted product of the adipocytes that regulates a variety of functions. The presence of the leptin receptor (LR) has been demonstrated in the endocrine and neuroendocrine tissue, but only limited information is available regarding cell-specific expression in the anterior pituitary gland. We have used double-label immunofluorescence histochemistry to study the distribution of LR-like immunoreactivity (LR-ir) in the corticotropes, somatotropes, and gonadotropes of the ovine anterior pituitary. LR-ir was found in 34% of cells in the pars distalis and 94% of the cells in the pars tuberalis. In the pars distalis, LR-ir was present in 27% of corticotropes, 69% of somatotropes, and 29% of gonadotropes. In contrast, 90% of the gonadotropes in the pars tuberalis were immunopositive for LR. There was no alteration in the number of gonadotropes containing LR-ir during the various phases of the estrous cycle (n = 3/group) in the pars distalis (luteal phase, 36%; follicular phase, 32%; and estrous phase, 32%). In conclusion, we show that, in the pars distalis, LR-ir is expressed to a greater extent in the somatotropes than in the gonadotropes or corticotropes. This is in accordance with the documented effects of leptin on pituitary GH secretion. The differential expression of LR-ir between the gonadotropes of the pars distalis and pars tuberalis probably reflects the different phenotypes of the cells in these two regions. Lower levels of LR-ir expression in gonadotropes and corticotropes of the pars distalis may suggest that leptin does not substantially influence these particular cells, at least in this species.
This article has been cited by other articles:
 |
|
 |
|
  J. Iqbal, O. Latchoumanin, I. P. Sari, R. J. Lang, H. A. Coleman, H. C. Parkington, and I. J. Clarke Estradiol-17{beta} Inhibits Gonadotropin-Releasing Hormone-Induced Ca2+ in Gonadotropes to Regulate Negative Feedback on Luteinizing Hormone Release Endocrinology, September 1, 2009; 150(9): 4213 - 4220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Accorsi, A. Munno, M. Gamberoni, R. Viggiani, M. De Ambrogi, C. Tamanini, and E. Seren Role of Leptin on Growth Hormone and Prolactin Secretion by Bovine Pituitary Explants J Dairy Sci, April 1, 2007; 90(4): 1683 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Luque, Z. H. Huang, B. Shah, T. Mazzone, and R. D. Kineman Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E891 - E899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, and C. Y. Bowers Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition Endocr. Rev., April 1, 2006; 27(2): 101 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. French, R. P. Littlejohn, G. J. Greer, W. E. Bain, J. C. McEwan, and D. J. Tisdall Growth hormone and ghrelin receptor genes are differentially expressed between genetically lean and fat selection lines of sheep J Anim Sci, February 1, 2006; 84(2): 324 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers Endocrine Control of Body Composition in Infancy, Childhood, and Puberty Endocr. Rev., February 1, 2005; 26(1): 114 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Maciel, D. A. Zieba, M. Amstalden, D. H. Keisler, J. P. Neves, and G. L. Williams Chronic administration of recombinant ovine leptin in growing beef heifers: Effects on secretion of LH, metabolic hormones, and timing of puberty J Anim Sci, October 1, 2004; 82(10): 2930 - 2936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bluher and C. S. Mantzoros The Role of Leptin in Regulating Neuroendocrine Function in Humans J. Nutr., September 1, 2004; 134(9): 2469S - 2474S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.A. Zieba, M. Amstalden, S. Morton, M.N. Maciel, D.H. Keisler, and G.L. Williams Regulatory Roles of Leptin at the Hypothalamic-Hypophyseal Axis Before and after Sexual Maturation in Cattle Biol Reprod, September 1, 2004; 71(3): 804 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kuriyama, S. Takekoshi, K. Tojo, Y. Nakai, M. J. Kuhar, and R. Y. Osamura Cocaine- and Amphetamine-Regulated Transcript Peptide in the Rat Anterior Pituitary Gland Is Localized in Gonadotrophs and Suppresses Prolactin Secretion Endocrinology, May 1, 2004; 145(5): 2542 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Anderson, S. Jeftinija, and C. G. Scanes Growth Hormone Secretion: Molecular and Cellular Mechanisms and In Vivo Approaches Experimental Biology and Medicine, April 1, 2004; 229(4): 291 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. McDuffie, N. Akhter, and G. V. Childs Regulation of Leptin mRNA and Protein Expression in Pituitary Somatotropes J. Histochem. Cytochem., February 1, 2004; 52(2): 263 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.N. Maciel, D.A. Zieba, M. Amstalden, D.H. Keisler, J.P. Neves, and G.L. Williams Leptin Prevents Fasting-Mediated Reductions in Pulsatile Secretion of Luteinizing Hormone and Enhances Its Gonadotropin-Releasing Hormone-Mediated Release in Heifers Biol Reprod, January 1, 2004; 70(1): 229 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Amstalden, D.A. Zieba, J.F. Edwards, P.G. Harms, T.H. Welsh Jr., R.L. Stanko, and G.L. Williams Leptin Acts at the Bovine Adenohypophysis to Enhance Basal and Gonadotropin-Releasing Hormone-Mediated Release of Luteinizing Hormone: Differential Effects Are Dependent upon Nutritional History Biol Reprod, November 1, 2003; 69(5): 1539 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Wettemann, C. A. Lents, N. H. Ciccioli, F. J. White, and I. Rubio Nutritional- and suckling-mediated anovulation in beef cows J Anim Sci, February 1, 2003; 81(14_suppl_2): E48 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Watanobe Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats J. Physiol., November 15, 2002; 545(1): 255 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kilciler, M. Ozata, C. Oktenli, S.Y. Sanisoglu, E. Bolu, N. Bingol, M. Kilciler, I. C. Ozdemir, and M. Kutlu Diurnal Leptin Secretion Is Intact in Male Hypogonadotropic Hypogonadism and Is Not Influenced by Exogenous Gonadotropins J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 5023 - 5029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Watanobe and S. Habu Leptin Regulates Growth Hormone-Releasing Factor, Somatostatin, and alpha -Melanocyte-Stimulating Hormone But Not Neuropeptide Y Release in Rat Hypothalamus In Vivo: Relation with Growth Hormone Secretion J. Neurosci., July 15, 2002; 22(14): 6265 - 6271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baratta, R. Saleri, G. L. Mainardi, D. Valle, A. Giustina, and C. Tamanini Leptin Regulates GH Gene Expression and Secretion and Nitric Oxide Production in Pig Pituitary Cells Endocrinology, February 1, 2002; 143(2): 551 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-G. Roh, G.-Y. Nie, K. Loneragan, A. Gertler, and C. Chen Direct Modification of Somatotrope Function by Long-Term Leptin Treatment of Primary Cultured Ovine Pituitary Cells Endocrinology, December 1, 2001; 142(12): 5167 - 5171. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
