help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reese, J.
Right arrow Articles by Dey, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reese, J.
Right arrow Articles by Dey, S. K.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
Endocrinology Vol. 141, No. 5 1872-1881
Copyright © 2000 by The Endocrine Society

ARTICLES

Implantation and Decidualization Defects in Prolactin Receptor (PRLR)-Deficient Mice Are Mediated by Ovarian But Not Uterine PRLR1

Jeff Reese, Nadine Binart, Naoko Brown, Wen-ge Ma, B. C. Paria, S. K. Das, Paul A. Kelly and S. K. Dey

Departments of Pediatrics (J.R., N.Br., B.C.P.), Molecular and Integrative Physiology (W.-g.M., S.K.De.) and Obstetrics and Gynecology (S.K.Da.), Ralph L. Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160-7338; and INSERM U344 Molecular Endocrinology (N.Bi., P.A.K.), Paris, France

Address all correspondence and requests for reprints to: Jeff Reese, Department of Pediatrics, 3043 Wescoe Building, 3901 Rainbow Boulevard, University of Kansas Medical Center, Kansas City, Kansas 66160-7338. E-mail: jreese{at}kumc.edu

PRL and its homologs accomplish their biological effects through the PRL receptor (PRLR). We evaluated the expression and function of PRLR in the embryo and uterus during the periimplantation period because PRLR deficiency results in implantation failure. In wild-type mice, PRLR expression was localized to undecidualized stromal cells in the antimesometrial border on days 6–8 of pregnancy. A small population of PRLR-expressing cells was observed adjacent to the ectoplacental cone in the mesometrial stroma. Low levels of PRLR expression were also detected in the developing embryo on days 6–8. To determine the significance of PRLR expression in this distribution, we examined implantation and decidualization in PRLR-/- mice. Progesterone (P4) administration rescued infertility in PRLR-/- mice from the periimplantation period to midgestation. Artificially induced decidualization was absent in pseudopregnant PRLR-/- mice but was identical to wild-type in P4-treated PRLR-/- mice. Furthermore, wild-type and P4-treated PRLR-/- mice had similar expression of the implantation-specific genes, LIF, amphiregulin, HB-EGF, COX-1, COX-2, PPAR{delta}, Hoxa-10, cyclin-D3, VEGF, and its receptors, Flk-1 and neuropilin-1. Together, these results show that luteal P4 production via ovarian PRLR signaling is required for implantation and early pregnancy. The function of uterine PRLR remains unclear. However, the eventual loss of pregnancy in P4-treated PRLR-/- mice suggests that uterine PRLR may be essential for the support of late gestation.




This article has been cited by other articles:


Home page
 EndocrinologyHome page
L. Bao, C. Tessier, A. Prigent-Tessier, F. Li, O. L. Buzzio, E. A. Callegari, N. D. Horseman, and G. Gibori
Decidual Prolactin Silences the Expression of Genes Detrimental to Pregnancy
Endocrinology, May 1, 2007; 148(5): 2326 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. J. LeBaron, T. J. Ahonen, M. T. Nevalainen, and H. Rui
In Vivo Response-Based Identification of Direct Hormone Target Cell Populations Using High-Density Tissue Arrays
Endocrinology, March 1, 2007; 148(3): 989 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. Stocco, C. Telleria, and G. Gibori
The Molecular Control of Corpus Luteum Formation, Function, and Regression
Endocr. Rev., February 1, 2007; 28(1): 117 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Q. Panzan, J. M. S. Junior, E. L. A. da Motta, E. F. Haapalainen, M. de Jesus Simoes, H. A. Baptista, M. A. Haidar, and E. C. Baracat
Metoclopramide-induced hyperprolactinaemia caused marked decline in pinopodes and pregnancy rates in mice
Hum. Reprod., October 1, 2006; 21(10): 2514 - 2520.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. Tessier, A. Prigent-Tessier, L. Bao, C. M. Telleria, S. Ferguson-Gottschall, G. B. Gibori, Y. Gu, J. M. Bowen-Shauver, N. D. Horseman, and G. Gibori
Decidual Activin: Its Role In the Apoptotic Process and Its Regulation by Prolactin
Biol Reprod, May 1, 2003; 68(5): 1687 - 1694.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Baran, P. A. Kelly, and N. Binart
Decysin, a New Member of the Metalloproteinase Family, Is Regulated by Prolactin and Steroids During Mouse Pregnancy
Biol Reprod, May 1, 2003; 68(5): 1787 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. S. Moons, S. Jirawatnotai, A. F. Parlow, G. Gibori, R. D. Kineman, and H. Kiyokawa
Pituitary Hypoplasia and Lactotroph Dysfunction in Mice Deficient for Cyclin-Dependent Kinase-4
Endocrinology, August 1, 2002; 143(8): 3001 - 3008.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Cui, K. Miyoshi, E. Claudio, U. K. Siebenlist, F. J. Gonzalez, J. Flaws, K.-U. Wagner, and L. Hennighausen
Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARgamma ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility
J. Biol. Chem., May 10, 2002; 277(20): 17830 - 17835.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Baran, P. A. Kelly, and N. Binart
Characterization of a Prolactin-Regulated Gene in Reproductive Tissues Usingthe Prolactin Receptor Knockout Mouse Model
Biol Reprod, April 1, 2002; 66(4): 1210 - 1218.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. S. Moons, S. Jirawatnotai, T. Tsutsui, R. Franks, A. F. Parlow, D. B. Hales, G. Gibori, A. T. Fazleabas, and H. Kiyokawa
Intact Follicular Maturation and Defective Luteal Function in Mice Deficient for Cyclin- Dependent Kinase-4
Endocrinology, February 1, 2002; 143(2): 647 - 654.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Tessier, A. Prigent-Tessier, S. Ferguson-Gottschall, Y. Gu, and G. Gibori
PRL Antiapoptotic Effect in the Rat Decidua Involves the PI3K/Protein Kinase B-Mediated Inhibition of Caspase-3 Activity
Endocrinology, September 1, 2001; 142(9): 4086 - 4094.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Prigent-Tessier, U. Barkai, C. Tessier, H. Cohen, and G. Gibori
Characterization of a Rat Uterine Cell Line, UIII Cells: Prolactin (PRL) Expression and Endogenous Regulation of PRL-Dependent Genes; Estrogen Receptor {{beta}}, {{alpha}}2-Macroglobulin, and Decidual PRL Involving the Jak2 and Stat5 Pathway
Endocrinology, March 1, 2001; 142(3): 1242 - 1250.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society