help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coschigano, K. T.
Right arrow Articles by Kopchick, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coschigano, K. T.
Right arrow Articles by Kopchick, J. J.
Endocrinology Vol. 141, No. 7 2608-2613
Copyright © 2000 by The Endocrine Society

ARTICLES

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice1

Karen T. Coschigano, David Clemmons, Linda L. Bellush and John J. Kopchick

Edison Biotechnology Institute (K.T.C., L.L.B., J.J.K.), Ohio University, Athens, Ohio 45701; Division of Endocrinology and Metabolism (D.C.), Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7170; Molecular and Cellular Biology Program, Ohio University (L.L.B., J.J.K.), Athens, Ohio 45701; and Department of Biomedical Sciences (J.J.K.), College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701

Address all correspondence and requests for reprints to: Dr. John J. Kopchick, Edison Biotechnology Institute, Ohio University, 101 Konneker Research Laboratories, The Ridges, Athens, Ohio 45701. E-mail: kopchick{at}ohio.edu

GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with its receptor. We chose to study the effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome (LS) in which the GHR/BP gene has been disrupted. We observed that mice homozygous for the disruption (-/-) were significantly smaller than normal wild-type (+/+) mice as well as mice heterozygous for the disruption, even at 1.5 yr of age. IGF-I levels were also significantly lower in the -/- mice and remained low as the mice aged. IGFBP-3 levels were severely reduced in the -/- mice, whereas IGFBP-1, -2, and -4 levels remained unchanged. Finally, the -/- mice lived significantly longer than +/+ and +/- mice. The latter result contradicts the anti-aging GH data and suggests the need for further analysis of GH and aging.




This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
J. Svensson and B.-A. Bengtsson
Safety aspects of GH replacement
Eur. J. Endocrinol., November 1, 2009; 161(S1): S65 - S74.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
J. A. Panici, F. Wang, M. S. Bonkowski, A. Spong, A. Bartke, L. Pawlikowska, P.-Y. Kwok, and M. M. Masternak
Is Altered Expression of Hepatic Insulin-Related Genes in Growth Hormone Receptor Knockout Mice Due to GH Resistance or a Difference in Biological Life Spans?
J Gerontol A Biol Sci Med Sci, November 1, 2009; 64A(11): 1126 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
M. M. Masternak, J. A. Panici, M. S. Bonkowski, L. F. Hughes, and A. Bartke
Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity
J Gerontol A Biol Sci Med Sci, May 1, 2009; 64A(5): 516 - 521.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
W.-L. Yen and D. J. Klionsky
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
Physiology, October 1, 2008; 23(5): 248 - 262.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. F. Giani, M. S. Bonkowski, M. C. Munoz, M. M. Masternak, D. Turyn, A. Bartke, and F. P. Dominici
Insulin Signaling Cascade in the Hearts of Long-Lived Growth Hormone Receptor Knockout Mice: Effects of Calorie Restriction
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2008; 63(8): 788 - 797.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. Selman, S. Lingard, A. I. Choudhury, R. L. Batterham, M. Claret, M. Clements, F. Ramadani, K. Okkenhaug, E. Schuster, E. Blanc, et al.
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
FASEB J, March 1, 2008; 22(3): 807 - 818.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. R. Heydari, A. Unnikrishnan, L. V. Lucente, and A. Richardson
Caloric restriction and genomic stability
Nucleic Acids Res., December 3, 2007; 35(22): 7485 - 7496.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. K. Reddy, D. Amador-Noguez, G. J. Darlington, B. A. Scholz, L. H. Michael, C. J. Hartley, M. L. Entman, and G. E. Taffet
Cardiac Function in Young and Old Little Mice
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2007; 62(12): 1319 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Chandrashekar, C. R. Dawson, E. R. Martin, J. S. Rocha, A. Bartke, and J. J. Kopchick
Age-Related Alterations in Pituitary and Testicular Functions in Long-Lived Growth Hormone Receptor Gene-Disrupted Mice
Endocrinology, December 1, 2007; 148(12): 6019 - 6025.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M J E Walenkamp and J M Wit
Genetic disorders in the GH IGF-I axis in mouse and man
Eur. J. Endocrinol., August 1, 2007; 157(suppl_1): S15 - S26.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. Egecioglu, I. J. Andersson, E. Bollano, V. Palsdottir, B. G. Gabrielsson, J. J. Kopchick, O. Skott, P. Bie, J. Isgaard, M. Bohlooly-Y, et al.
Growth hormone receptor deficiency in mice results in reduced systolic blood pressure and plasma renin, increased aortic eNOS expression, and altered cardiovascular structure and function
Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1418 - E1425.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
K. A. Al-Regaiey, M. M. Masternak, M. S. Bonkowski, J. A. Panici, J. J. Kopchick, and A. Bartke
Effects of Caloric Restriction and Growth Hormone Resistance on Insulin-Related Intermediates in the Skeletal Muscle
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 18 - 26.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
Y. Higami, T. Tsuchiya, T. Chiba, H. Yamaza, I. Muraoka, M. Hirose, T. Komatsu, and I. Shimokawa
Hepatic Gene Expression Profile of Lipid Metabolism in Rats: Impact of Caloric Restriction and Growth Hormone/Insulin-Like Growth Factor-1 Suppression
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1099 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. M. Harper, S. J. Durkee, R. C. Dysko, S. N. Austad, and R. A. Miller
Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice.
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2006; 61(10): 1019 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Robertson, J. J. Kopchick, and J.-L. Liu
Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E491 - E498.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Xu, Z. Liu, T. L. Clemens, and J. L. Messina
Insulin Reverses Growth Hormone-induced Homologous Desensitization
J. Biol. Chem., August 4, 2006; 281(31): 21594 - 21606.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. S. Bonkowski, R. W. Pamenter, J. S. Rocha, M. M. Masternak, J. A. Panici, and A. Bartke
Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics.
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 562 - 567.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. E. Berryman, E. O. List, D. T. Kohn, K. T. Coschigano, R. J. Seeley, and J. J. Kopchick
Effect of Growth Hormone on Susceptibility to Diet-Induced Obesity
Endocrinology, June 1, 2006; 147(6): 2801 - 2808.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. S. Bonkowski, J. S. Rocha, M. M. Masternak, K. A. Al Regaiey, and A. Bartke
From the Cover: Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
PNAS, May 16, 2006; 103(20): 7901 - 7905.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. Egecioglu, M. Bjursell, A. Ljungberg, S. L. Dickson, J. J. Kopchick, G. Bergstrom, L. Svensson, J. Oscarsson, J. Tornell, and M. Bohlooly-Y
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice
Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E317 - E325.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
R. W. Powers III, M. Kaeberlein, S. D. Caldwell, B. K. Kennedy, and S. Fields
Extension of chronological life span in yeast by decreased TOR pathway signaling
Genes & Dev., January 15, 2006; 20(2): 174 - 184.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. E. Rowland, L. M. Kerr, M. White, P. G. Noakes, and M. J. Waters
Heterozygote Effects in Mice with Partial Truncations in the Growth Hormone Receptor Cytoplasmic Domain: Assessment of Growth Parameters and Phenotype
Endocrinology, December 1, 2005; 146(12): 5278 - 5286.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
H. R. Warner
Developing a Research Agenda in Biogerontology: Basic Mechanisms
Sci. Aging Knowl. Environ., November 2, 2005; 2005(44): pe33 - pe33.
[Abstract] [Full Text]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. M. Masternak, K. A. Al-Regaiey, M. M. Del Rosario Lim, V. Jimenez-Ortega, J. A. Panici, M. S. Bonkowski, J. J. Kopchick, and A. Bartke
Effects of Caloric Restriction and Growth Hormone Resistance on the Expression Level of Peroxisome Proliferator-Activated Receptors Superfamily in Liver of Normal and Long-Lived Growth Hormone Receptor/Binding Protein Knockout Mice
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2005; 60(11): 1394 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. M. Masternak, K. A. Al-Regaiey, M. M. Del Rosario Lim, M. S. Bonkowski, J. A. Panici, G. K. Przybylski, and A. Bartke
Caloric Restriction Results in Decreased Expression of Peroxisome Proliferator-Activated Receptor Superfamily in Muscle of Normal and Long-Lived Growth Hormone Receptor/Binding Protein Knockout Mice
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1238 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Bartke
Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian Aging
Endocrinology, September 1, 2005; 146(9): 3718 - 3723.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. E. Sonntag, C. S. Carter, Y. Ikeno, K. Ekenstedt, C. S. Carlson, R. F. Loeser, S. Chakrabarty, S. Lee, C. Bennett, R. Ingram, et al.
Adult-Onset Growth Hormone and Insulin-Like Growth Factor I Deficiency Reduces Neoplastic Disease, Modifies Age-Related Pathology, and Increases Life Span
Endocrinology, July 1, 2005; 146(7): 2920 - 2932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. B. Salmon, S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress
Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E23 - E29.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J. R. Speakman
Body size, energy metabolism and lifespan
J. Exp. Biol., May 1, 2005; 208(9): 1717 - 1730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. A. Hsieh, C. M. Chai, and M. K. Hellerstein
Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding
Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E965 - E972.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
Z. D. Sharp and A. Bartke
Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2005; 60(3): 293 - 300.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. A. Al-Regaiey, M. M. Masternak, M. Bonkowski, L. Sun, and A. Bartke
Long-Lived Growth Hormone Receptor Knockout Mice: Interaction of Reduced Insulin-Like Growth Factor I/Insulin Signaling and Caloric Restriction
Endocrinology, February 1, 2005; 146(2): 851 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. E. Rowland, A. M. Lichanska, L. M. Kerr, M. White, E. M. d'Aniello, S. L. Maher, R. Brown, R. D. Teasdale, P. G. Noakes, and M. J. Waters
In Vivo Analysis of Growth Hormone Receptor Signaling Domains and Their Associated Transcripts
Mol. Cell. Biol., January 1, 2005; 25(1): 66 - 77.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. P. de Magalhaes, J. A. S. Cabral, and D. Magalhaes
The Influence of Genes on the Aging Process of Mice: A Statistical Assessment of the Genetics of Aging
Genetics, January 1, 2005; 169(1): 265 - 274.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. Vergara, M. Smith-Wheelock, J. M. Harper, R. Sigler, and R. A. Miller
Hormone-Treated Snell Dwarf Mice Regain Fertility But Remain Long Lived and Disease Resistant
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2004; 59(12): 1244 - 1250.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. C. Patel, N. P. Nunez, S. N. Perkins, J. C. Barrett, and S. D. Hursting
Effects of Energy Balance on Cancer in Genetically Altered Mice
J. Nutr., December 1, 2004; 134(12): 3394S - 3398S.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
A J van der Lely
Justified and unjustified use of growth hormone
Postgrad. Med. J., October 1, 2004; 80(948): 577 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
C. V. Mobbs
Not Wisely but Too Well: Aging as a Cost of Neuroendocrine Activity
Sci. Aging Knowl. Environ., September 1, 2004; 2004(35): pe33 - pe33.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
S. D. Hursting, J. A. Lavigne, D. Berrigan, L. A. Donehower, B. J. Davis, J. M. Phang, J. C. Barrett, and S. N. Perkins
Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target
J. Nutr., September 1, 2004; 134(9): 2482S - 2486S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J.-L. Liu, K. T. Coschigano, K. Robertson, M. Lipsett, Y. Guo, J. J. Kopchick, U. Kumar, and Y. L. Liu
Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E405 - E413.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
F. M. Martin and J. S. Friedman
Ticking Fast or Ticking Slow, Through Shc Must You Go?
Sci. Aging Knowl. Environ., August 11, 2004; 2004(32): pe32 - pe32.
[Abstract] [Full Text]

Home page
 Sci Aging Knowl EnvironHome page
J. K. Quarrie and K. T. Riabowol
Murine Models of Life Span Extension
Sci. Aging Knowl. Environ., August 4, 2004; 2004(31): re5 - re5.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
M. M. Masternak, K. Al-Regaiey, M. S. Bonkowski, J. Panici, L. Sun, J. Wang, G. K. Przybylski, and A. Bartke
Divergent Effects of Caloric Restriction on Gene Expression in Normal and Long-Lived Mice
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2004; 59(8): B784 - B788.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
J. M. S. Burger and D. E. L. Promislow
Sex-Specific Effects of Interventions That Extend Fly Life Span
Sci. Aging Knowl. Environ., July 14, 2004; 2004(28): pe30 - pe30.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. Mesotten, P. J. Wouters, R. P. Peeters, K. V. Hardman, J. M. Holly, R. C. Baxter, and G. Van den Berghe
Regulation of the Somatotropic Axis by Intensive Insulin Therapy during Protracted Critical Illness
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3105 - 3113.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
R. N. Butler, R. Sprott, H. Warner, J. Bland, R. Feuers, M. Forster, H. Fillit, S. M. Harman, M. Hewitt, M. Hyman, et al.
Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2004; 59(6): B560 - B567.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
T. Tsuchiya, J. M. Dhahbi, X. Cui, P. L. Mote, A. Bartke, and S. R. Spindler
Additive regulation of hepatic gene expression by dwarfism and caloric restriction
Physiol Genomics, May 19, 2004; 17(3): 307 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. M. Dhahbi, H.-J. Kim, P. L. Mote, R. J. Beaver, and S. R. Spindler
Temporal linkage between the phenotypic and genomic responses to caloric restriction
PNAS, April 13, 2004; 101(15): 5524 - 5529.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Barbieri, M. Bonafe, C. Franceschi, and G. Paolisso
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1064 - E1071.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
K. J. Bitterman, O. Medvedik, and D. A. Sinclair
Longevity Regulation in Saccharomyces cerevisiae: Linking Metabolism, Genome Stability, and Heterochromatin
Microbiol. Mol. Biol. Rev., September 1, 2003; 67(3): 376 - 399.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. T. Coschigano, A. N. Holland, M. E. Riders, E. O. List, A. Flyvbjerg, and J. J. Kopchick
Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span
Endocrinology, September 1, 2003; 144(9): 3799 - 3810.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
I. Chen
The Mouse That Roared
Sci. Aging Knowl. Environ., August 27, 2003; 2003(34): nf16 - 16.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Besson, S. Salemi, S. Gallati, A. Jenal, R. Horn, P. S. Mullis, and P. E. Mullis
Reduced Longevity in Untreated Patients with Isolated Growth Hormone Deficiency
J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3664 - 3667.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. W. Nelson and R. W. Padgett
Insulin worms its way into the spotlight
Genes & Dev., April 1, 2003; 17(7): 813 - 818.
[Full Text] [PDF]

Home page
 ScienceHome page
V. D. Longo and C. E. Finch
Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?
Science, February 28, 2003; 299(5611): 1342 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Tatar, A. Bartke, and A. Antebi
The Endocrine Regulation of Aging by Insulin-like Signals
Science, February 28, 2003; 299(5611): 1346 - 1351.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
E. J. Masoro
Subfield History: Caloric Restriction, Slowing Aging, and Extending Life
Sci. Aging Knowl. Environ., February 26, 2003; 2003(8): re2 - 2.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. Koubova and L. Guarente
How does calorie restriction work?
Genes & Dev., February 1, 2003; 17(3): 313 - 321.
[Full Text] [PDF]

Home page
 ScienceHome page
M. Bluher, B. B. Kahn, and C. R. Kahn
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Science, January 24, 2003; 299(5606): 572 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. A. Miller, Y. Chang, A. T. Galecki, K. Al-Regaiey, J. J. Kopchick, and A. Bartke
Gene Expression Patterns in Calorically Restricted Mice: Partial Overlap with Long-Lived Mutant Mice
Mol. Endocrinol., November 1, 2002; 16(11): 2657 - 2666.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. J. Kopchick, C. Parkinson, E. C. Stevens, and P. J. Trainer
Growth Hormone Receptor Antagonists: Discovery, Development, and Use in Patients with Acromegaly
Endocr. Rev., October 1, 2002; 23(5): 623 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. Zaczek, J. Hammond, L. Suen, S. Wandji, D. Service, A. Bartke, V. Chandrashekar, K. Coschigano, and J. Kopchick
Impact of Growth Hormone Resistance on Female Reproductive Function: New Insights from Growth Hormone Receptor Knockout Mice
Biol Reprod, October 1, 2002; 67(4): 1115 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
D. E. Keene, M. O. Suescun, M. G. Bostwick, V. Chandrashekar, A. Bartke, and J. J. Kopchick
Puberty Is Delayed in Male Growth Hormone Receptor Gene--Disrupted Mice
J Androl, September 1, 2002; 23(5): 661 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
R. N. Butler, M. Fossel, S. M. Harman, C. B. Heward, S. J. Olshansky, T. T. Perls, D. J. Rothman, S. M. Rothman, H. R. Warner, M. D. West, et al.
Is There an Antiaging Medicine?
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2002; 57(9): B333 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. J. Olshansky, L. Hayflick, and B. A. Carnes
Position Statement on Human Aging
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2002; 57(8): B292 - 297.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. A. Miller, J. M. Harper, R. C. Dysko, S. J. Durkee, and S. N. Austad
Longer Life Spans and Delayed Maturation in Wild-Derived Mice
Experimental Biology and Medicine, July 1, 2002; 227(7): 500 - 508.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
S. J. Olshansky, L. Hayflick, and B. A. Carnes
Position Statement on Human Aging
Sci. Aging Knowl. Environ., June 19, 2002; 2002(24): pe9 - 9.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
I. Shimokawa, Y. Higami, M. Utsuyama, T. Tuchiya, T. Komatsu, T. Chiba, and H. Yamaza
Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model
Am. J. Pathol., June 1, 2002; 160(6): 2259 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C. S. Carter, M. M. Ramsey, R. L. Ingram, A. B. Cashion, W. T. Cefalu, Z.Q. Wang, and W. E. Sonntag
Models of Growth Hormone and IGF-1 Deficiency: Applications to Studies of Aging Processes and Life-Span Determination
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2002; 57(5): B177 - 188.
[Abstract] [Full Text]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
I. Dozmorov, A. Galecki, Y. Chang, R. Krzesicki, M. Vergara, and R. A. Miller
Gene Expression Profile of Long-Lived Snell Dwarf Mice
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2002; 57(3): B99 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
F. P. Dominici and D. Turyn
Growth Hormone-Induced Alterations in the Insulin-Signaling System
Experimental Biology and Medicine, March 1, 2002; 227(3): 149 - 157.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
Growth Hormone Receptor Knockout (Laron) Mice
Sci. Aging Knowl. Environ., February 27, 2002; 2002(8): tg1 - 1.
[Full Text]

Home page
 Exp. Biol. Med.Home page
H. M. Brown-Borg, S. G. Rakoczy, M. A. Romanick, and M. A. Kennedy
Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Hepatocyte Antioxidative Enzymes
Experimental Biology and Medicine, February 1, 2002; 227(2): 94 - 104.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
Little Mice
Sci. Aging Knowl. Environ., October 24, 2001; 2001(4): tg14 - 14.
[Full Text]

Home page
 Toxicol PatholHome page
J. F. Mahler
Mutant Models of Prolonged Life Span
Toxicol Pathol, October 1, 2001; 29(6): 673 - 676.
[Abstract] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Klebanov, C. M. Astle, T. H. Roderick, K. Flurkey, J. R. Archer, J. Chen, and D. E. Harrison
Maximum Life Spans in Mice Are Extended by Wild Strain Alleles
Experimental Biology and Medicine, October 1, 2001; 226(9): 854 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. J. Hauck, W. S. Hunter, N. Danilovich, J. J. Kopchick, and A. Bartke
Reduced Levels of Thyroid Hormones, Insulin, and Glucose, and Lower Body Core Temperature in the Growth Hormone Receptor/Binding Protein Knockout Mouse
Experimental Biology and Medicine, June 1, 2001; 226(6): 552 - 558.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. J. Clancy, D. Gems, L. G. Harshman, S. Oldham, H. Stocker, E. Hafen, S. J. Leevers, and L. Partridge
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
Science, April 6, 2001; 292(5514): 104 - 106.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
X.-d. Peng, S. Park, M. R. Gadelha, K. T. Coschigano, J. J. Kopchick, L. A. Frohman, and R. D. Kineman
The Growth Hormone (GH)-Axis of GH Receptor/Binding Protein Gene-Disrupted and Metallothionein-Human GH-Releasing Hormone Transgenic Mice: Hypothalamic Neuropeptide and Pituitary Receptor Expression in the Absence and Presence of GH Feedback
Endocrinology, March 1, 2001; 142(3): 1117 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C. V. Mobbs, G. A. Bray, R. L. Atkinson, A. Bartke, C. E. Finch, E. Maratos-Flier, J. N. Crawley, and J. F. Nelson
Neuroendocrine and Pharmacological Manipulations to Assess How Caloric Restriction Increases Life Span
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2001; 56(90001): 34 - 44.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society