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Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078-8510, Japan
Address all correspondence and requests for reprints to: Toshikatsu Okumura, M.D., Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078-8510, Japan. E-mail: okumurat{at}asahikawa-med.ac.jp
Recent study has indicated that cocaine-amphetamine-regulated
transcript (CART) is an anorectic chemical in the brain. In the present
study, we examined the hypothesis that CART may act in the central
nervous system to alter gastric function. Food consumption, gastric
acid secretion, and gastric emptying were measured after injection of
CART into the cerebrospinal fluid in 24-h fasted Sprague Dawley rats.
Central injection of CART inhibited food intake, gastric acid
secretion, and gastric emptying. In contrast, ip injection of CART
failed to inhibit gastric acid secretion and gastric emptying,
suggesting that CART acts in the brain to suppress gastric acid
secretion and gastric emptying. In the vagotomized animals, centrally
administered CART did inhibit pentagastrin-stimulated gastric acid
secretion. The CART-induced acid inhibition was also observed in rats
treated with indomethacin, a cyclooxygenase inhibitor. In contrast,
pretreatment with central administration of a CRF receptor antagonist,
-helical CRF9–41, completely blocked the central CART-induced
inhibition of gastric acid secretion. All these results suggest that
CART acts in the brain to inhibit gastric function via brain CRF
system. The vagal pathway and the prostaglandin system are not involved
in the acid inhibition.
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