help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Deol, H. K.
Right arrow Articles by DiMattia, G. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Deol, H. K.
Right arrow Articles by DiMattia, G. E.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CALCIUM COMPOUNDS
*CALCIUM, ELEMENTAL
Medline Plus Health Information
*Hormones
Endocrinology Vol. 141, No. 9 3412-3421
Copyright © 2000 by The Endocrine Society

ARTICLES

Dynamic Regulation of Mouse Ovarian Stanniocalcin Expression during Gestation and Lactation1

Harminder K. Deol2, Robin Varghese2, Graham F. Wagner and Gabriel E. DiMattia

Departments of Biochemistry (R.V., G.E.D.), Oncology (G.E.D.), Physiology (H.D., G.W.) and Obstetrics/Gynecology (G.E.D.) in the Faculty of Medicine and Dentistry, The University of Western Ontario, and the London Regional Cancer Center (G.E.D.), London, Ontario, Canada

Address all correspondence and requests for reprints to: Dr. Gabriel DiMattia, London Regional Cancer Centre, 790 Commissioners Road, London, Ontario N6A 4L6. E-mail: dimattia{at}julian.uwo.ca

Stanniocalcin is a glycoprotein hormone that appears to play a paracine/autocrine role in several mammalian tissues. Recently studies have shown that stanniocalcin is highly expressed in the ovaries of mice and humans and we have investigated its expression in the mouse ovary during several physiological states to identify potential functional relationships. During postnatal development the pattern of stanniocalcin (STC) gene expression begins to become thecal-restricted as early as day 5 and achieves the adult pattern of expression by two weeks of age. During postnatal development the primary sites of STC protein localization are the theca and oocytes and after maturation it is also strongly concentrated in the corpora lutea. Over the estrous cycle the pattern of both STC gene expression and protein localization do not show dramatic changes though STC immunoreactivity (STCir) staining appears to be greatest during metestrus I. In the superovulation model, however, we observed a significant increase in STC messenger RNA (mRNA) levels after treatment with hCG implying regulation by LH. During gestation the expression of ovarian STC increases 15-fold and is localized to the theca-interstitial cells with lower expression also being found in the corpora lutea. STC also becomes detectable in the serum for the first time suggesting an endocrine role for STC during gestation. Interestingly, the presence of a nursing litter appears to up-regulate STC gene expression in lactating mice suggesting a role for ovarian STC in lactation. Also striking is the intense STCir staining found in oocytes as they are devoid of STC mRNA, thus implying a role for STC in oocyte maturation. Stanniocalcin, to our knowledge, is unique because no other secreted proteins produced by the ovarian thecal-interstitial compartment are significantly induced during mouse pregnancy. In summary, our data provide evidence for the active regulation of STC expression in the ovary during gestation and lactation and therefore implies that STC is a new regulator of the gestational and nursing state.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
Y. Wang, L. Huang, M. Abdelrahim, Q. Cai, A. Truong, R. Bick, B. Poindexter, and D. Sheikh-Hamad
Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2
J. Leukoc. Biol., October 1, 2009; 86(4): 981 - 988.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
M. C. Loiselle, C. Ster, B. G. Talbot, X. Zhao, G. F. Wagner, Y. R. Boisclair, and P. Lacasse
Impact of postpartum milking frequency on the immune system and the blood metabolite concentration of dairy cows
J Dairy Sci, May 1, 2009; 92(5): 1900 - 1912.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
G. Tremblay, P. Bernier-Dodier, L. Delbecchi, G. F. Wagner, B. G. Talbot, and P. Lacasse
Local control of mammary involution: Is stanniocalcin-1 involved?
J Dairy Sci, May 1, 2009; 92(5): 1998 - 2006.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Huang, G. Garcia, Y. Lou, Q. Zhou, L. D. Truong, G. DiMattia, X. R. Lan, H. Y. Lan, Y. Wang, and D. Sheikh-Hamad
Anti-Inflammatory and Renal Protective Actions of Stanniocalcin-1 in a Model of Anti-Glomerular Basement Membrane Glomerulonephritis
Am. J. Pathol., April 1, 2009; 174(4): 1368 - 1378.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. Raulic, Y. Ramos-Valdes, and G. E DiMattia
Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro
J. Endocrinol., June 1, 2008; 197(3): 517 - 529.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. C.-M. Chang, J. Hook, F. A. Lemckert, M. M. McDonald, M.-A. T. Nguyen, E. C. Hardeman, D. G. Little, P. W. Gunning, and R. R. Reddel
The Murine Stanniocalcin 2 Gene Is a Negative Regulator of Postnatal Growth
Endocrinology, May 1, 2008; 149(5): 2403 - 2410.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
N. Miller, L. Delbecchi, D. Petitclerc, G. F. Wagner, B. G. Talbot, and P. Lacasse
Effect of Stage of Lactation and Parity on Mammary Gland Cell Renewal
J Dairy Sci, December 1, 2006; 89(12): 4669 - 4677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. Zaidi, K. A. James, and G. F. Wagner
Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E974 - E981.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
L.-J. Xiao, J.-X. Yuan, X.-X. Song, Y.-C. Li, Z.-Y. Hu, and Y.-X. Liu
Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization.
Reproduction, June 1, 2006; 131(6): 1137 - 1149.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. Song, F. W. Bazer, G. F. Wagner, and T. E. Spencer
Stanniocalcin (STC) in the Endometrial Glands of the Ovine Uterus: Regulation by Progesterone and Placental Hormones
Biol Reprod, May 1, 2006; 74(5): 913 - 922.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. C.-M. Chang, J. Cha, F. Koentgen, and R. R. Reddel
The Murine Stanniocalcin 1 Gene Is Not Essential for Growth and Development
Mol. Cell. Biol., December 1, 2005; 25(23): 10604 - 10610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. P. Hasilo, C. R. McCudden, J. R. J. Gillespie, K. A. James, E. R. Hirvi, D. Zaidi, and G. F. Wagner
Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation
Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E634 - E642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Paciga, E. R. Hirvi, K. James, and G. F. Wagner
Characterization of big stanniocalcin variants in mammalian adipocytes and adrenocortical cells
Am J Physiol Endocrinol Metab, August 1, 2005; 289(2): E197 - E205.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. D. Gagliardi, E. Y. W. Kuo, S. Raulic, G. F. Wagner, and G. E. DiMattia
Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs
Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E92 - E105.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Paciga, G. E. DiMattia, and G. F. Wagner
Regulation of Luteal Cell Big Stanniocalcin Production and Secretion
Endocrinology, September 1, 2004; 145(9): 4204 - 4212.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C.-W. Luo, K. Kawamura, C. Klein, and A. J. W. Hsueh
Paracrine Regulation of Ovarian Granulosa Cell Differentiation by Stanniocalcin (STC) 1: Mediation through Specific STC1 Receptors
Mol. Endocrinol., August 1, 2004; 18(8): 2085 - 2096.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Paciga, C. R. McCudden, C. Londos, G. E. DiMattia, and G. F. Wagner
Targeting of Big Stanniocalcin and Its Receptor to Lipid Storage Droplets of Ovarian Steroidogenic Cells
J. Biol. Chem., December 5, 2003; 278(49): 49549 - 49554.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Y. Yeung, D. K. O. Chan, N. K. Mak, G. F. Wagner, and C. K. C. Wong
Identification of Signal Transduction Pathways that Modulate Dibutyryl Cyclic Adenosine Monophosphate Activation of Stanniocalcin Gene Expression in Neuroblastoma Cells
Endocrinology, October 1, 2003; 144(10): 4446 - 4452.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. R. McCudden, K. A. James, C. Hasilo, and G. F. Wagner
Characterization of Mammalian Stanniocalcin Receptors. MITOCHONDRIAL TARGETING OF LIGAND AND RECEPTOR FOR REGULATION OF CELLULAR METABOLISM
J. Biol. Chem., November 15, 2002; 277(47): 45249 - 45258.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Paciga, A. J. Watson, G. E. DiMattia, and G. F. Wagner
Ovarian Stanniocalcin Is Structurally Unique in Mammals and Its Production and Release Are Regulated through the Luteinizing Hormone Receptor
Endocrinology, October 1, 2002; 143(10): 3925 - 3934.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. H. Filvaroff, S. Guillet, C. Zlot, M. Bao, G. Ingle, H. Steinmetz, J. Hoeffel, S. Bunting, J. Ross, R. A. D. Carano, et al.
Stanniocalcin 1 Alters Muscle and Bone Structure and Function in Transgenic Mice
Endocrinology, September 1, 2002; 143(9): 3681 - 3690.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. L. Welcsh, M. K. Lee, R. M. Gonzalez-Hernandez, D. J. Black, M. Mahadevappa, E. M. Swisher, J. A. Warrington, and M.-C. King
BRCA1 transcriptionally regulates genes involved in breast tumorigenesis
PNAS, May 28, 2002; 99(11): 7560 - 7565.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Varghese, A. D. Gagliardi, P. E. Bialek, S.-P. Yee, G. F. Wagner, and G. E. Dimattia
Overexpression of Human Stanniocalcin Affects Growth and Reproduction in Transgenic Mice
Endocrinology, March 1, 2002; 143(3): 868 - 876.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Bouras, M. C. Southey, A. C. Chang, R. R. Reddel, D. Willhite, R. Glynne, M. A. Henderson, J. E. Armes, and D. J. Venter
Stanniocalcin 2 Is an Estrogen-responsive Gene Coexpressed with the Estrogen Receptor in Human Breast Cancer
Cancer Res., March 1, 2002; 62(5): 1289 - 1295.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. Ishibashi and M. Imai
Prospect of a stanniocalcin endocrine/paracrine system in mammals
Am J Physiol Renal Physiol, March 1, 2002; 282(3): F367 - F375.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. R. McCudden, W.H. Tam, and G. F. Wagner
Ovarian Stanniocalcin in Trout Is Differentially Glycosylated and Preferentially Expressed in Early Stage Oocytes
Biol Reprod, September 1, 2001; 65(3): 763 - 770.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society