| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ARTICLES |
Department of Metabolic Medicine, Imperial College School of Medicine, London, United Kingdom W12 0NN
Address all correspondence and requests for reprints to: Prof. S. R. Bloom, Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London, United Kingdom W12 0NN. E-mail: s.bloom{at}ic.ac.uk
PRL-releasing peptide inhibits food intake after intracerebroventricular injection. PRL-releasing peptide immunoreactivity is found in several hypothalamic nuclei involved in feeding, with highest levels in the paraventricular and dorsomedial hypothalamic nuclei. The aim of this study was to examine the effect of PRL-releasing peptide on food intake after administration into these nuclei.
Paraventricular nucleus injection of PRL-releasing peptide did not alter food intake. Dorsomedial hypothalamic nucleus injection of PRL-releasing peptide decreased 1 h food intake [PRL-releasing peptide (1 nmol) 83.4 ± 6.1% saline all; P < 0.05]; and continued until 8 h postinjection [PRL-releasing peptide (1 nmol) 89.2 ± 4.1% saline; P < 0.05].
To investigate the mechanism of this inhibition of food intake, we
examined PRL-releasing peptide’s effect on neuropeptide release from
hypothalamic explants. 
MSH release was increased [PRL-releasing
peptide (100 nmol), 5.4 ± 1.6 pmol/explant; change
vs. basal, P < 0.01], whereas
agouti-related protein release was unchanged. The release of
cocaine- and amphetamine-regulated transcript was inhibited
[PRL-releasing peptide (100 nmol), -33.5 ± 12.6 pmol/explant;
change vs. basal, P < 0.01].
PRL-releasing peptide dose-dependently increased neurotensin
release [PRL-releasing peptide (1 nmol), 3.7 ± 2.6 pmol/explant;
change vs. basal, P = NS;
PRL-releasing peptide (10 nmol), 7.2 ± 2.7 pmol/explant; change
vs. basal, P < 0.01; PRL-releasing
peptide (100 nmol), 36.8 ± 5.4 pmol/explant; change
vs. basal, P < 0.001].
Our data suggest that the dorsomedial hypothalamic nucleus is important in the inhibitory effect of PRL-releasing peptide on food intake and that PRL-releasing peptide alters the release of several hypothalamic neuropeptides important in the control of food intake.
This article has been cited by other articles:
 |
|
 |
|
  S. Moriyama, M. Kasahara, N. Amiya, A. Takahashi, M. Amano, S. A. Sower, K. Yamamori, and H. Kawauchi RFamide Peptides Inhibit the Expression of Melanotropin and Growth Hormone Genes in the Pituitary of an Agnathan, the Sea Lamprey, Petromyzon marinus Endocrinology, August 1, 2007; 148(8): 3740 - 3749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Kelly and R. E. Peter Prolactin-releasing peptide, food intake, and hydromineral balance in goldfish Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1474 - R1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Smith, M. Patterson, W. S. Dhillo, S. R. Patel, N. M. Semjonous, J. V. Gardiner, M. A. Ghatei, and S. R. Bloom Neuropeptide S Stimulates the Hypothalamo-Pituitary-Adrenal Axis and Inhibits Food Intake Endocrinology, July 1, 2006; 147(7): 3510 - 3518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Stanley, K. Wynne, B. McGowan, and S. Bloom Hormonal Regulation of Food Intake Physiol Rev, October 1, 2005; 85(4): 1131 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Bewick, W. S. Dhillo, S. J. Darch, K. G. Murphy, J. V. Gardiner, P. H. Jethwa, W. M. Kong, M. A. Ghatei, and S. R. Bloom Hypothalamic Cocaine- and Amphetamine-Regulated Transcript (CART) and Agouti-Related Protein (AgRP) Neurons Coexpress the NOP1 Receptor and Nociceptin Alters CART and AgRP Release Endocrinology, August 1, 2005; 146(8): 3526 - 3534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Lawrence, Y.-L. Liu, M. J. Stock, and S. M. Luckman Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R101 - R107. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Ueta, Y. Ozaki, J. Saito, and T. Onaka Involvement of Novel Feeding-Related Peptides in Neuroendocrine Response to Stress Experimental Biology and Medicine, November 1, 2003; 228(10): 1168 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. J. Ellacott, C. B. Lawrence, L. E. Pritchard, and S. M. Luckman Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1005 - R1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Abbott, A. R. Kennedy, A. M. Wren, M. Rossi, K. G. Murphy, L. J. Seal, J. F. Todd, M. A. Ghatei, C. J. Small, and S. R. Bloom Identification of Hypothalamic Nuclei Involved in the Orexigenic Effect of Melanin-Concentrating Hormone Endocrinology, September 1, 2003; 144(9): 3943 - 3949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Dhillo, C. J. Small, P. H. Jethwa, S. H. Russell, J. V. Gardiner, G. A. Bewick, A. Seth, K. G. Murphy, M. A. Ghatei, and S. R. Bloom Paraventricular Nucleus Administration of Calcitonin Gene-Related Peptide Inhibits Food Intake and Stimulates the Hypothalamo-Pituitary-Adrenal Axis Endocrinology, April 1, 2003; 144(4): 1420 - 1425. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
