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Endocrinology Vol. 142, No. 12 5172-5181
Copyright © 2001 by The Endocrine Society

NEUROENDOCRINOLOGY

Coexpression of ERß with ER{alpha} and Progestin Receptor Proteins in the Female Rat Forebrain: Effects of Estradiol Treatment

Béatrice Gréco, E. A. Allegretto, M. J. Tetel and J. D. Blaustein

Center for Neuroendocrine Studies, University of Massachusetts (B.G., M.J.T., J.D.B.), Amherst, Massachusetts 01003; and DuPont Pharmaceuticals Co. (E.A.A.), Wilmington, Delaware 19880

Address all correspondence and requests for reprints to: Dr. Béatrice Gréco, Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655. E-mail: beatrice.greco{at}umassmed.edu

Estrogen and progestin receptors (ER, PgR) play a critical role in the regulation of neuroendocrine functions in females. The neuroanatomical distribution of the recently cloned, ERß, overlaps with both ER{alpha} and PgR. To determine whether ERß is found within ER{alpha}- or PgR-containing neurons in female rat, we used dual label immunocytochemistry. ERß-immunoreactivity (ERß-ir) was primarily detected in the nuclei of cells in the periventricular preoptic area (PvPO), the bed nucleus of the stria terminalis (BNSTpr), the paraventricular nucleus, the supraoptic nucleus, and the medial amygdala (MEApd). Coexpression of ERß-ir with ER{alpha}-ir or PgR-ir was observed in the PvPO, BNSTpr, and MEApd in ovariectomized rats. E2 treatment decreased the number of ERß-ir cells in the PvPO and BNSTpr and the number of ER{alpha}-ir cells in the MEApd and paraventricular nucleus, and therefore decreased the number of cells coexpressing ERß-ir and ER{alpha}-ir in the PvPO, BNSTpr, and MEApd. E2 treatment increased the amount of PgR-ir in cells of the PvPO, BNSTpr, and MEApd, a portion of which also contained ERß. These results demonstrate that ERß is expressed in ER{alpha}- or PgR-containing cells, and they suggest that E can modulate the ratios of these steroid receptors in a brain region-specific manner.




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