help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Craven, A. J.
Right arrow Articles by Pearson, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Craven, A. J.
Right arrow Articles by Pearson, A. J.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Endocrinology Vol. 142, No. 6 2533-2539
Copyright © 2001 by The Endocrine Society

ARTICLES

Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice1

A. J. Craven, C. J. Ormandy, F. G. Robertson, R. J. Wilkins, P. A. Kelly, A. J. Nixon and A. J. Pearson

New Zealand Pastoral Agriculture Research Institute (A.J.C., A.J.N., A.J.P.), Hamilton 2020, New Zealand; Cancer Research Program, Garvan Institute of Medical Research (C.J.O., F.G.R.), Darlinghurst, New South Wales 2010, Sydney, Australia; University of Waikato (A.J.C., R.J.W.), Hamilton 2020, New Zealand; and INSERM, U-344, Faculté de Médecine Hopital Necker-Enfants Malades (P.A.K.), Paris 75730, France

Address all correspondence and requests for reprints to: Tony Craven, AgResearch Ruakura, Private Bag 3123, Hamilton, New Zealand. E-mail: cravent{at}agresearch.cri.nz

Pituitary PRL regulates seasonal hair follicle growth cycles in many mammals. Here we present the first evidence implicating PRL in the nonseasonal, wave-like pelage replacement of laboratory mice. In this study we show that messenger RNA transcripts encoding the one long and two short forms of PRL receptor are present in the skin of adult and neonate mice. The receptor protein was immunolocalized to the hair follicle as well as the epidermis and sebaceous glands. Furthermore, PRL messenger RNA was detected within skin extracts, suggesting a possible autocrine/paracrine role. Analysis of the hair growth phenotype of PRL gene-disrupted mice (PRLR-/-) revealed a change in the timing of hair cycling events. Although no hair follicle development differences were noted in PRLR-/- neonates, observations of the second generation of hair growth revealed PRLR-/- mice molted earlier than wild types (PRLR+/+). The advance was greater in females (29 days) than in males (4 days), resulting in the elimination of the sexual dimorphism associated with murine hair replacement. Heterozygotes were intermediate between PRLR-/- and PRLR+/+ mice in molt onset. Once initiated, the pattern and progression of the molt across the body were similar in all genotypes. Although all fiber types were present and appeared structurally normal, PRLR-/- mice had slightly longer and coarser hair than wild types. These findings demonstrate that PRL has an inhibitory effect on murine hair cycle events. The pituitary PRL regulation of hair follicle cycles observed in seasonally responsive mammals may be a result of pituitary PRL interacting with a local regulatory mechanism.




This article has been cited by other articles:


Home page
 EndocrinologyHome page
M. J. LeBaron, T. J. Ahonen, M. T. Nevalainen, and H. Rui
In Vivo Response-Based Identification of Direct Hormone Target Cell Populations Using High-Density Tissue Arrays
Endocrinology, March 1, 2007; 148(3): 989 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A J Craven, A J Nixon, M G Ashby, C J Ormandy, K Blazek, R J Wilkins, and A J Pearson
Prolactin delays hair regrowth in mice.
J. Endocrinol., November 1, 2006; 191(2): 415 - 425.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Foitzik, K. Krause, F. Conrad, M. Nakamura, W. Funk, and R. Paus
Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression
Am. J. Pathol., March 1, 2006; 168(3): 748 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. M. Corbacho, G. Valacchi, L. Kubala, E. Olano-Martin, B. C. Schock, T. P. Kenny, and C. E. Cross
Tissue-specific gene expression of prolactin receptor in the acute-phase response induced by lipopolysaccharides
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E750 - E757.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G.A. Lincoln, H. Andersson, and I.J. Clarke
Prolactin Cycles in Sheep under Constant Photoperiod: Evidence That Photorefractoriness Develops Within the Pituitary Gland Independently of the Prolactin Output Signal
Biol Reprod, October 1, 2003; 69(4): 1416 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Foitzik, K. Krause, A. J. Nixon, C. A. Ford, U. Ohnemus, A. J. Pearson, and R. Paus
Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen
Am. J. Pathol., May 1, 2003; 162(5): 1611 - 1621.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2001 by The Endocrine Society