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Sex, Fat and the Tilt of the Earth: Effects of Sex and Season on the Feeding Response to Centrally Administered Leptin in Sheep

Prince Henry’s Institute of Medical Research (I.J.C., B.D.), Clayton, Victoria 3168, Australia; Department of Physiology (A.J.T., A.I.T.), Monash University, Victoria 3800, Australia; Department of Immunology and Pathology (J.R.G.), Monash University Medical School, Prahran, Victoria 3181, Australia

Whilst there have been many studies in various species examining the effects of leptin on food intake, there is a paucity of data comparing responsiveness in the two sexes. We have, therefore, addressed this issue in sheep. Because this species shows seasonal variation in voluntary food intake (VFI), we also considered the possibility that there might be seasonal variation in the responsivity to leptin. Centrally administered leptin was relatively ineffective as a satiety factor in either sex during Autumn. In Spring, leptin had a profound inhibitory effect on VFI in the females, but only a slight effect in males. These data indicate that responsiveness to leptin depends on sex and also on season in animals that are substantially affected by photoperiod.

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