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Department of Molecular Medicine, Karolinska Institute (A.F.-M., N.S., P.T.-E., G.N.), 17176 Stockholm, Sweden; Department of Biotechnology, KTH Royal Institute of Technology (J.L.), Stockholm 10044, Sweden; and Institute for Genomic Research (R.L.M., J.Q., N.H.L.), Rockville, Maryland 20850
Address all correspondence and requests for reprints to: Dr. Amilcar Flores-Morales, Department of Molecular Medicine, CMM, L8:01, Karolinska Hospital, 17176 Stockholm, Sweden. E-mail: amilcar.flores{at}molmed.ki.se
Complementary DNA microarrays containing 3000 different rat genes were used to study the consequences of severe hormonal deficiency (hypophysectomy) on the gene expression patterns in heart, liver, and kidney. Hybridization signals were seen from a majority of the arrayed complementary DNAs; nonetheless, tissue-specific expression patterns could be delineated. Hypophysectomy affected the expression of genes involved in a variety of cellular functions. Between 16–29% of the detected transcripts from each tissue changed expression level as a reaction to this condition. Chronic treatment of hypophysectomized animals with human GH also caused significant changes in gene expression patterns. The study confirms previous knowledge concerning certain gene expression changes in the above-mentioned situations and provides new information regarding hypophysectomy and chronic human GH effects in the rat. Furthermore, we have identified several new genes that respond to GH treatment. Our results represent a first step toward a more global understanding of gene expression changes in states of hormonal deficiency.
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P. Kotokorpi, C. Gardmo, C. S. Nystrom, and A. Mode Activation of the Glucocorticoid Receptor or Liver X Receptors Interferes with Growth Hormone-Induced akr1b7 Gene Expression in Rat Hepatocytes Endocrinology, December 1, 2004; 145(12): 5704 - 5713. [Abstract] [Full Text] [PDF]
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N. Stahlberg, E. Rico-Bautista, R. M. Fisher, X. Wu, L. Cheung, A. Flores-Morales, G. Tybring, G. Norstedt, and P. Tollet-Egnell Female-Predominant Expression of Fatty Acid Translocase/CD36 in Rat and Human Liver Endocrinology, April 1, 2004; 145(4): 1972 - 1979. [Abstract] [Full Text] [PDF]
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A. Ahluwalia, K. H. Clodfelter, and D. J. Waxman Sexual Dimorphism of Rat Liver Gene Expression: Regulatory Role of Growth Hormone Revealed by Deoxyribonucleic Acid Microarray Analysis Mol. Endocrinol., March 1, 2004; 18(3): 747 - 760. [Abstract] [Full Text] [PDF]
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K. Dillner, J. Kindblom, A. Flores-Morales, R. Shao, J. Tornell, G. Norstedt, and H. Wennbo Gene Expression Analysis of Prostate Hyperplasia in Mice Overexpressing the Prolactin Gene Specifically in the Prostate Endocrinology, November 1, 2003; 144(11): 4955 - 4966. [Abstract] [Full Text] [PDF]
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 X. Wu, S.-T. Pang, L. Sahlin, A. Blanck, G. Norstedt, and A. Flores-Morales Gene Expression Profiling of the Effects of Castration and Estrogen Treatment in the Rat Uterus Biol Reprod, October 1, 2003; 69(4): 1308 - 1317. [Abstract] [Full Text] [PDF]
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B. Olsson, M. Bohlooly-Y, O. Brusehed, O. G. P. Isaksson, B. Ahren, S.-O. Olofsson, J. Oscarsson, and J. Tornell Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes Am J Physiol Endocrinol Metab, September 1, 2003; 285(3): E504 - E511. [Abstract] [Full Text] [PDF]
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A. H. Casse, D. Desplanches, M. H. Mayet-Sornay, M. Raccurt, S. Jegou, and G. Morel Growth Hormone Receptor Expression in Atrophying Muscle Fibers of Rats Endocrinology, August 1, 2003; 144(8): 3692 - 3697. [Abstract] [Full Text] [PDF]
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H. C. Mertani, M. Raccurt, A. Abbate, J. Kindblom, J. Tornell, N. Billestrup, Y. Usson, G. Morel, and P. E. Lobie Nuclear Translocation and Retention of Growth Hormone Endocrinology, July 1, 2003; 144(7): 3182 - 3195. [Abstract] [Full Text] [PDF]
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M. Jalouli, L. Carlsson, C. Ameen, D. Linden, A. Ljungberg, L. Michalik, S. Eden, W. Wahli, and J. Oscarsson Sex Difference in Hepatic Peroxisome Proliferator-Activated Receptor {alpha} Expression: Influence of Pituitary and Gonadal Hormones Endocrinology, January 1, 2003; 144(1): 101 - 109. [Abstract] [Full Text] [PDF]
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S.-T. Pang, K. Dillner, X. Wu, A. Pousette, G. Norstedt, and A. Flores-Morales Gene Expression Profiling of Androgen Deficiency Predicts a Pathway of Prostate Apoptosis that Involves Genes Related to Oxidative Stress Endocrinology, December 1, 2002; 143(12): 4897 - 4906. [Abstract] [Full Text] [PDF]
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F. Frick, D. Linden, C. Ameen, S. Eden, A. Mode, and J. Oscarsson Interaction between growth hormone and insulin in the regulation of lipoprotein metabolism in the rat Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E1023 - E1031. [Abstract] [Full Text] [PDF]
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A. Flores-Morales, H. Gullberg, L. Fernandez, N. Stahlberg, N. H. Lee, B. Vennstrom, and G. Norstedt Patterns of Liver Gene Expression Governed by TR{beta} Mol. Endocrinol., June 1, 2002; 16(6): 1257 - 1268. [Abstract] [Full Text] [PDF]
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D. Soulet and S. Rivest Perspective: How to Make Microarray, Serial Analysis of Gene Expression, and Proteomic Relevant to Day-to-Day Endocrine Problems and Physiological Systems Endocrinology, June 1, 2002; 143(6): 1995 - 2001. [Abstract] [Full Text] [PDF]
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