help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harris, H. A.
Right arrow Articles by Katzenellenbogen, B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, H. A.
Right arrow Articles by Katzenellenbogen, B. S.
Endocrinology Vol. 143, No. 11 4172-4177
Copyright © 2002 by The Endocrine Society

ARTICLE

Characterization of the Biological Roles of the Estrogen Receptors, ER{alpha} and ERß, in Estrogen Target Tissues in Vivo through the Use of an ER{alpha}-Selective Ligand

Heather A. Harris, John A. Katzenellenbogen and Benita S. Katzenellenbogen

Women’s Health Research Institute (H.H.), Wyeth Research, Collegeville, Pennsylvania 19426; and Departments of Chemistry (J.A.K.) and Molecular and Integrative Physiology (B.S.K.), University of Illinois, Urbana, Illinois 61801

Address all correspondence and requests for reprints to: Dr. Benita S. Katzenellenbogen, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Avenue, University of Illinois, Urbana, Illinois 61801-3704. E-mail: katzenel{at}life.uiuc.edu.

Estrogens elicit many biomedically important responses in different target tissues, and the respective roles of the two estrogen receptors, ER{alpha} and ERß, in mediating these bioactivities is incompletely understood. In this study, we investigated the activity of an ER{alpha}-selective agonist ligand, propyl pyrazole triol (PPT), in several rat animal models to define the involvement of ER{alpha} in these biological responses. In a short-term (4 d) uterotrophic assay, PPT was found to be as efficacious as 17{alpha}-ethinyl-17ß-estradiol in stimulating uterine weight gain and up-regulating complement 3 gene expression. In a 6-wk chronic model, PPT completely prevented the ovariectomy-induced body weight increase and loss of bone mineral density. It also increased uterine weight and markedly reduced plasma cholesterol levels in these mature animals. PPT was also effective in the brain. It increased progesterone receptor mRNA in the arcuate and ventromedial nuclei of the hypothalamus and prevented experimentally induced hot flushes. Our findings indicate that several physiologically relevant estrogen-induced tissue responses can be effectively evoked via ER{alpha} alone. By providing an approach that is complementary to that of analyzing the phenotype and response of ER knockout animals, our findings also demonstrate that ER subtype-selective ligands can play a valuable role in enhancing our understanding of how estrogens work through the two ER subtypes.




This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
A. A. Kazi, K. H. Molitoris, and R. D. Koos
Estrogen Rapidly Activates the PI3K/AKT Pathway and Hypoxia-Inducible Factor 1 and Induces Vascular Endothelial Growth Factor A Expression in Luminal Epithelial Cells of the Rat Uterus
Biol Reprod, August 1, 2009; 81(2): 378 - 387.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. Braniste, M. Leveque, C. Buisson-Brenac, L. Bueno, J. Fioramonti, and E. Houdeau
Oestradiol decreases colonic permeability through oestrogen receptor \#946;-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells
J. Physiol., July 1, 2009; 587(13): 3317 - 3328.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
J. G. F. Hogervorst, L. J. Schouten, E. J. M. Konings, R. A. Goldbohm, and P. A. van den Brandt
Lung Cancer Risk in Relation to Dietary Acrylamide Intake
J Natl Cancer Inst, May 6, 2009; 101(9): 651 - 662.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L Lundholm, G Bryzgalova, H Gao, N Portwood, S Falt, K D Berndt, A Dicker, D Galuska, J R Zierath, J-A Gustafsson, et al.
The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms
J. Endocrinol., November 1, 2008; 199(2): 275 - 286.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yokota, K. Oritani, K. P. Garrett, T. Kouro, M. Nishida, I. Takahashi, M. Ichii, Y. Satoh, P. W. Kincade, and Y. Kanakura
Soluble Frizzled-Related Protein 1 Is Estrogen Inducible in Bone Marrow Stromal Cells and Suppresses the Earliest Events in Lymphopoiesis
J. Immunol., November 1, 2008; 181(9): 6061 - 6072.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Sirianni, A. Chimento, C. Ruggiero, A. De Luca, R. Lappano, S. Ando, M. Maggiolini, and V. Pezzi
The Novel Estrogen Receptor, G Protein-Coupled Receptor 30, Mediates the Proliferative Effects Induced by 17{beta}-Estradiol on Mouse Spermatogonial GC-1 Cell Line
Endocrinology, October 1, 2008; 149(10): 5043 - 5051.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
A. Mattsson, J. A Olsson, and B. Brunstrom
Selective estrogen receptor {alpha} activation disrupts sex organ differentiation and induces expression of vitellogenin II and very low-density apolipoprotein II in Japanese quail embryos
Reproduction, August 1, 2008; 136(2): 175 - 186.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. C. Catley, M. A. Birrell, E. L. Hardaker, J. de Alba, S. Farrow, S. Haj-Yahia, and M. G. Belvisi
Estrogen Receptor {beta}: Expression Profile and Possible Anti-Inflammatory Role in Disease
J. Pharmacol. Exp. Ther., July 1, 2008; 326(1): 83 - 88.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. W. Sinkevicius, J. E. Burdette, K. Woloszyn, S. C. Hewitt, K. Hamilton, S. L. Sugg, K. A. Temple, F. E. Wondisford, K. S. Korach, T. K. Woodruff, et al.
An Estrogen Receptor-{alpha} Knock-In Mutation Provides Evidence of Ligand-Independent Signaling and Allows Modulation of Ligand-Induced Pathways in Vivo
Endocrinology, June 1, 2008; 149(6): 2970 - 2979.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. C. Carroll and C. J. Pike
Selective Estrogen Receptor Modulators Differentially Regulate Alzheimer-Like Changes in Female 3xTg-AD Mice
Endocrinology, May 1, 2008; 149(5): 2607 - 2611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Santollo, M. D. Wiley, and L. A. Eckel
Acute activation of ER{alpha} decreases food intake, meal size, and body weight in ovariectomized rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2194 - R2201.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Tiwari-Woodruff, L. B. J. Morales, R. Lee, and R. R. Voskuhl
Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER){alpha} and ERbeta ligand treatment
PNAS, September 11, 2007; 104(37): 14813 - 14818.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. Arreguin-Arevalo, T. L. Davis, and T. M. Nett
Differential Modulation of Gonadotropin Secretion by Selective Estrogen Receptor 1 and Estrogen Receptor 2 Agonists in Ovariectomized Ewes
Biol Reprod, August 1, 2007; 77(2): 320 - 328.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
D. Stygar, B. Masironi, H. Eriksson, and L. Sahlin
Studies on estrogen receptor (ER) {alpha} and {beta} responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists
J. Endocrinol., July 1, 2007; 194(1): 101 - 119.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Zheng, A. Kallio, and P. Harkonen
Tamoxifen-Induced Rapid Death of MCF-7 Breast Cancer Cells Is Mediated via Extracellularly Signal-Regulated Kinase Signaling and Can Be Abrogated by Estrogen
Endocrinology, June 1, 2007; 148(6): 2764 - 2777.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. A. Harris
Estrogen Receptor-{beta}: Recent Lessons from in Vivo Studies
Mol. Endocrinol., January 1, 2007; 21(1): 1 - 13.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. N. Sundar, V. Kerekatte, C. N. Equinozio, V. B. Doan, L. F. Bjeldanes, and G. L. Firestone
Indole-3-Carbinol Selectively Uncouples Expression and Activity of Estrogen Receptor Subtypes in Human Breast Cancer Cells
Mol. Endocrinol., December 1, 2006; 20(12): 3070 - 3082.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J. Bowe, X. F. Li, J. Kinsey-Jones, A. Heyerick, S. Brain, S. Milligan, and K. O'Byrne
The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.
J. Endocrinol., November 1, 2006; 191(2): 399 - 405.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Galmiche, N. Richard, S. Corvaisier, and M.-L. Kottler
The Expression of Aromatase in Gonadotropes Is Regulated by Estradiol and Gonadotropin-Releasing Hormone in a Manner that Differs from the Regulation of Luteinizing Hormone
Endocrinology, September 1, 2006; 147(9): 4234 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. W. Hsieh, S. S. Rajan, S. K. Sharma, Y. Guo, E. R. DeSombre, M. Mrksich, and G. L. Greene
Identification of Ligands with Bicyclic Scaffolds Provides Insights into Mechanisms of Estrogen Receptor Subtype Selectivity
J. Biol. Chem., June 30, 2006; 281(26): 17909 - 17919.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. B. J. Morales, K. K. Loo, H.-b. Liu, C. Peterson, S. Tiwari-Woodruff, and R. R. Voskuhl
Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis.
J. Neurosci., June 21, 2006; 26(25): 6823 - 6833.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. J. Warden, L. K. Saxon, A. B. Castillo, and C. H. Turner
Knee ligament mechanical properties are not influenced by estrogen or its receptors
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E1034 - E1040.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J Christoffel, G Rimoldi, and W Wuttke
Effects of 8-prenylnaringenin on the hypothalamo-pituitary-uterine axis in rats after 3-month treatment.
J. Endocrinol., March 1, 2006; 188(3): 397 - 405.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. D. Lund, L. R. Hinds, and R. J. Handa
The Androgen 5{alpha}-Dihydrotestosterone and Its Metabolite 5{alpha}-Androstan-3beta, 17beta-Diol Inhibit the Hypothalamo-Pituitary-Adrenal Response to Stress by Acting through Estrogen Receptor beta-Expressing Neurons in the Hypothalamus
J. Neurosci., February 1, 2006; 26(5): 1448 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. T. Follettie, M. Pinard, J. C. Keith Jr., L. Wang, D. Chelsky, C. Hayward, P. Kearney, P. Thibault, E. Paramithiotis, A. J. Dorner, et al.
Organ Messenger Ribonucleic Acid and Plasma Proteome Changes in the Adjuvant-Induced Arthritis Model: Responses to Disease Induction and Therapy with the Estrogen Receptor-{beta} Selective Agonist ERB-041
Endocrinology, February 1, 2006; 147(2): 714 - 723.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Bodo, A. E. Kudwa, and E. F. Rissman
Both Estrogen Receptor-{alpha} and -{beta} Are Required for Sexual Differentiation of the Anteroventral Periventricular Area in Mice
Endocrinology, January 1, 2006; 147(1): 415 - 420.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Kublickiene, E. Svedas, B.-M. Landgren, M. Crisby, N. Nahar, H. Nisell, and L. Poston
Small Artery Endothelial Dysfunction in Postmenopausal Women: In Vitro Function, Morphology, and Modification by Estrogen and Selective Estrogen Receptor Modulators
J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6113 - 6122.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. S. Komm, Y. P. Kharode, P. V. N. Bodine, H. A. Harris, C. P. Miller, and C. R. Lyttle
Bazedoxifene Acetate: A Selective Estrogen Receptor Modulator with Improved Selectivity
Endocrinology, September 1, 2005; 146(9): 3999 - 4008.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. A. Schreihofer, K. D. Do, and A. M. Schreihofer
High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R103 - R108.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Gingerich and T. L. Krukoff
Estrogen Modulates Endothelial and Neuronal Nitric Oxide Synthase Expression via an Estrogen Receptor {beta}-Dependent Mechanism in Hypothalamic Slice Cultures
Endocrinology, July 1, 2005; 146(7): 2933 - 2941.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. R. Miller, T. Jover, H. W. Cohen, R. S. Zukin, and A. M. Etgen
Estrogen Can Act via Estrogen Receptor {alpha} and {beta} to Protect Hippocampal Neurons against Global Ischemia-Induced Cell Death
Endocrinology, July 1, 2005; 146(7): 3070 - 3079.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Rai, A. Frolova, J. Frasor, A. E. Carpenter, and B. S. Katzenellenbogen
Distinctive Actions of Membrane-Targeted Versus Nuclear Localized Estrogen Receptors in Breast Cancer Cells
Mol. Endocrinol., June 1, 2005; 19(6): 1606 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M M. Elloso, K. Phiel, R. A Henderson, H. A Harris, and S. J Adelman
Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands
J. Endocrinol., May 1, 2005; 185(2): 243 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
G.-S. Lee, H.-J. Kim, Y.-W. Jung, K.-C. Choi, and E.-B. Jeung
Estrogen Receptor {alpha} Pathway Is Involved in the Regulation of Calbindin-D9k in the Uterus of Immature Rats
Toxicol. Sci., April 1, 2005; 84(2): 270 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
V. Krishnan, H. A. Bullock, B. C. Yaden, M. Liu, R. J. Barr, C. Montrose-Rafizadeh, K. Chen, J. A. Dodge, and H. U. Bryant
The Nongenotropic Synthetic Ligand 4-Estren-3{alpha}17{beta}-diol Is a High-Affinity Genotropic Androgen Receptor Agonist
Mol. Pharmacol., March 1, 2005; 67(3): 744 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. C. Chadwick, S. Chippari, E. Matelan, L. Borges-Marcucci, A. M. Eckert, J. C. Keith Jr., L. M. Albert, Y. Leathurby, H. A. Harris, R. A. Bhat, et al.
Identification of pathway-selective estrogen receptor ligands that inhibit NF-{kappa}B transcriptional activity
PNAS, February 15, 2005; 102(7): 2543 - 2548.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. D. Lund, T. Rovis, W. C. J. Chung, and R. J. Handa
Novel Actions of Estrogen Receptor-{beta} on Anxiety-Related Behaviors
Endocrinology, February 1, 2005; 146(2): 797 - 807.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. M. Egan, J. A. Lawson, S. Fries, B. Koller, D. J. Rader, E. M. Smyth, and G. A. FitzGerald
COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice
Science, December 10, 2004; 306(5703): 1954 - 1957.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. Zaitseva, D. S. Yue, J. A. Katzenellenbogen, P. A. W. Rogers, and C. E. Gargett
Estrogen Receptor-{alpha} Agonists Promote Angiogenesis in Human Myometrial Microvascular Endothelial Cells
Reproductive Sciences, December 1, 2004; 11(8): 529 - 535.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
V. M. Navarro, J. M. Castellano, R. Fernandez-Fernandez, M. L. Barreiro, J. Roa, J. E. Sanchez-Criado, E. Aguilar, C. Dieguez, L. Pinilla, and M. Tena-Sempere
Developmental and Hormonally Regulated Messenger Ribonucleic Acid Expression of KiSS-1 and Its Putative Receptor, GPR54, in Rat Hypothalamus and Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide
Endocrinology, October 1, 2004; 145(10): 4565 - 4574.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A.G.B. Hurst, D.W. Goad, M. Mohan, and J.R. Malayer
Independent Downstream Gene Expression Profiles in the Presence of Estrogen Receptor {alpha} or {beta}
Biol Reprod, October 1, 2004; 71(4): 1252 - 1261.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H.V.O. Carswell, I.M. Macrae, L. Gallagher, E. Harrop, and K.J. Horsburgh
Neuroprotection by a selective estrogen receptor {beta} agonist in a mouse model of global ischemia
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1501 - H1504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. S. Lovegrove, J. Sun, K. A. Gould, D. B. Lubahn, K. S. Korach, and P. H. Lane
Estrogen receptor {alpha}-mediated events promote sex-specific diabetic glomerular hypertrophy
Am J Physiol Renal Physiol, September 1, 2004; 287(3): F586 - F591.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. Carta and D. Sassoon
Wnt7a Is a Suppressor of Cell Death in the Female Reproductive Tract and Is Required for Postnatal and Estrogen-Mediated Growth
Biol Reprod, August 1, 2004; 71(2): 444 - 454.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J.-x. Zhang, D. C. Labaree, G. Mor, and R. B. Hochberg
Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3527 - 3535.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
V. Unfer, M. L. Casini, L. Costabile, M. Mignosa, S. Gerli, and G. C. Di Renzo
High Dose of Phytoestrogens Can Reverse the Antiestrogenic Effects of Clomiphene Citrate on the Endometrium in Patients Undergoing Intrauterine Insemination: A Randomized Trial
Reproductive Sciences, July 1, 2004; 11(5): 323 - 328.
[Abstract] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Hillisch, O. Peters, D. Kosemund, G. Muller, A. Walter, B. Schneider, G. Reddersen, W. Elger, and K.-H. Fritzemeier
Dissecting Physiological Roles of Estrogen Receptor {alpha} and {beta} with Potent Selective Ligands from Structure-Based Design
Mol. Endocrinol., July 1, 2004; 18(7): 1599 - 1609.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Stossi, D. H. Barnett, J. Frasor, B. Komm, C. R. Lyttle, and B. S. Katzenellenbogen
Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) {alpha} or ER{beta} in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors
Endocrinology, July 1, 2004; 145(7): 3473 - 3486.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. B. Hawkins and P. Thomas
The Unusual Binding Properties of the Third Distinct Teleost Estrogen Receptor Subtype ER{beta}a Are Accompanied by Highly Conserved Amino Acid Changes in the Ligand Binding Domain
Endocrinology, June 1, 2004; 145(6): 2968 - 2977.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Barchiesi, E. K. Jackson, B. Imthurn, J. Fingerle, D. G. Gillespie, and R. K. Dubey
Differential Regulation of Estrogen Receptor Subtypes {alpha} and {beta} in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol
J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2373 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. A. Iannone, C. A. Simmons, S. H. Kadwell, D. L. Svoboda, D. E. Vanderwall, S.-J. Deng, T. G. Consler, J. Shearin, J. G. Gray, and K. H. Pearce
Correlation between in Vitro Peptide Binding Profiles and Cellular Activities for Estrogen Receptor-Modulating Compounds
Mol. Endocrinol., May 1, 2004; 18(5): 1064 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Hegele-Hartung, P. Siebel, O. Peters, D. Kosemund, G. Muller, A. Hillisch, A. Walter, J. Kraetzschmar, and K.-H. Fritzemeier
Impact of isotype-selective estrogen receptor agonists on ovarian function
PNAS, April 6, 2004; 101(14): 5129 - 5134.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Tena-Sempere, V.M. Navarro, A. Mayen, C. Bellido, and J.E. Sanchez-Criado
Regulation of Estrogen Receptor (ER) Isoform Messenger RNA Expression by Different ER Ligands in Female Rat Pituitary
Biol Reprod, March 1, 2004; 70(3): 671 - 678.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Ikeda, A. Nagai, M.-A. Ikeda, and S. Hayashi
Sexually Dimorphic and Estrogen-Dependent Expression of Estrogen Receptor {beta} in the Ventromedial Hypothalamus during Rat Postnatal Development
Endocrinology, November 1, 2003; 144(11): 5098 - 5104.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. P. McDonnell
Mining the Complexities of the Estrogen Signaling Pathways for Novel Therapeutics
Endocrinology, October 1, 2003; 144(10): 4237 - 4240.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
H. A. Harris, L. M. Albert, Y. Leathurby, M. S. Malamas, R. E. Mewshaw, C. P. Miller, Y. P. Kharode, J. Marzolf, B. S. Komm, R. C. Winneker, et al.
Evaluation of an Estrogen Receptor-{beta} Agonist in Animal Models of Human Disease
Endocrinology, October 1, 2003; 144(10): 4241 - 4249.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Frasor, D. H. Barnett, J. M. Danes, R. Hess, A. F. Parlow, and B. S. Katzenellenbogen
Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) {alpha} Activity by ER{beta} in the Uterus
Endocrinology, July 1, 2003; 144(7): 3159 - 3166.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Sun, J. Baudry, J. A. Katzenellenbogen, and B. S. Katzenellenbogen
Molecular Basis for the Subtype Discrimination of the Estrogen Receptor-{beta}-Selective Ligand, Diarylpropionitrile
Mol. Endocrinol., February 1, 2003; 17(2): 247 - 258.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2002 by The Endocrine Society