help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Combs, T. P.
Right arrow Articles by Moller, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Combs, T. P.
Right arrow Articles by Moller, D. E.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*METFORMIN HYDROCHLORIDE
Endocrinology Vol. 143, No. 3 998-1007
Copyright © 2002 by The Endocrine Society


INSULIN-GLUCAGON-GI PEPTIDES-DIABETES MELLITUS

Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPAR{gamma} Agonists: A Potential Mechanism of Insulin Sensitization

Terry P. Combs, John A. Wagner, Joel Berger, Tom Doebber, Wen-Jun Wang, Bei B. Zhang, Michael Tanen, Anders H Berg, Stephen O’Rahilly, David B. Savage, Krishna Chatterjee, Stuart Weiss, Patrick J. Larson, Keith M. Gottesdiener, Barry J. Gertz, Maureen J. Charron, Philipp E. Scherer and David E. Moller

Departments of Cell Biology (T.P.C., A.H.B., P.E.S.) and Biochemistry (W.-H.W., M.J.C.) Albert Einstein College of Medicine, Bronx, New York 10461; Departments of Molecular Endocrinology (J.B., T.D., B.B.Z., M.T., D.E.M.), Clinical Pharmacology (J.A.W., K.M.G., B.J.G.), and Clinical Biostatistics and Research Data Systems (P.J.L.), Merck Research Laboratories, Rahway, New Jersey 07065; Departments of Medicine and Clinical Biochemistry (S.O’R., D.B.S., K.C.), University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 2QQ, United Kingdom; and San Diego Endocrine and Metabolic Clinic (S.W.), San Diego, California 92108

Address all correspondence and requests for reprints to: Philipp Scherer, Albert Einstein College of Medicine, Chanin 414, Department of Cell Biology, 1300 Morris Park Avenue, Bronx, New York 10461. E-mail: . scherer{at}aecom.yu.edu

Adipocyte complement-related protein of 30 kDa (Acrp30, adiponectin, or AdipoQ) is a fat-derived secreted protein that circulates in plasma. Adipose tissue expression of Acrp30 is lower in insulin-resistant states and it is implicated in the regulation of in vivo insulin sensitivity. Here we have characterized the ability of PPAR{gamma} agonists to modulate Acrp30 expression. After chronic treatment of obese-diabetic (db/db) mice with PPAR{gamma} agonists (11 d), mean plasma Acrp30 protein levels increased (>3x). Similar effects were noted in a nongenetic type 2 diabetes model (fat-fed and low-dose streptozotocin-treated mice). In contrast, treatment of mice (db/db or fat-fed) with metformin or a PPAR{alpha} agonist did not affect plasma Acrp30 protein levels. In a cohort of normal human subjects, 14-d treatment with rosiglitazone also produced a 130% increase in circulating Acrp30 levels vs. placebo. In addition, circulating Acrp30 levels were suppressed 5-fold in patients with severe insulin resistance in association with dominant-negative PPAR{gamma} mutations. Thus, induction of adipose tissue Acrp30 expression and consequent increases in circulating Acrp30 levels represents a novel potential mechanism for PPAR{gamma}-mediated enhancement of whole-body insulin sensitivity. Furthermore, Acrp30 is likely to be a biomarker of in vivo PPAR{gamma} activation.




This article has been cited by other articles:


Home page
Clin. Cancer Res.Home page
S. Landskroner-Eiger, B. Qian, E. S. Muise, A. R. Nawrocki, J. P. Berger, E. J. Fine, W. Koba, Y. Deng, J. W. Pollard, and P. E. Scherer
Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo
Clin. Cancer Res., May 15, 2009; 15(10): 3265 - 3276.
[Abstract] [Full Text] [PDF]


Home page
Eur J EndocrinolHome page
Z. Kovacova, M. Vitkova, M. Kovacikova, E. Klimcakova, M. Bajzova, Z. Hnevkovska, L. Rossmeislova, V. Stich, D. Langin, and J. Polak
Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet
Eur. J. Endocrinol., April 1, 2009; 160(4): 585 - 592.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
A. Xu, H. Wang, R. L. C. Hoo, G. Sweeney, Paul. M. Vanhoutte, Y. Wang, D. Wu, W. Chu, G. Qin, and K. S. L. Lam
Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice
Endocrinology, February 1, 2009; 150(2): 625 - 633.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
A. Cassidy, P. Skidmore, E. B. Rimm, A. Welch, S. Fairweather-Tait, J. Skinner, K. Burling, J. B. Richards, T. D. Spector, and A. J. MacGregor
Plasma Adiponectin Concentrations Are Associated with Body Composition and Plant-Based Dietary Factors in Female Twins
J. Nutr., February 1, 2009; 139(2): 353 - 358.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. Liu, L. Zhou, A. Xu, K. S. L. Lam, M. D. Wetzel, R. Xiang, J. Zhang, X. Xin, L. Q. Dong, and F. Liu
From the Cover: A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization
PNAS, November 25, 2008; 105(47): 18302 - 18307.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
S. A. Shore, E. S. Williams, and M. Zhu
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice
J Appl Physiol, October 1, 2008; 105(4): 1127 - 1133.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
S. A. Phillips, T. P. Ciaraldi, Deborah. K. Oh, M. K. Savu, and R. R. Henry
Adiponectin secretion and response to pioglitazone is depot dependent in cultured human adipose tissue
Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E842 - E850.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
E. S. Muise, B. Azzolina, D. W. Kuo, M. El-Sherbeini, Y. Tan, X. Yuan, J. Mu, J. R. Thompson, J. P. Berger, and K. K. Wong
Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor {gamma} and Altered Metabolic States
Mol. Pharmacol., August 1, 2008; 74(2): 403 - 412.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
K. Takahashi, S. Yamaguchi, T. Shimoyama, H. Seki, K. Miyokawa, H. Katsuta, T. Tanaka, K. Yoshimoto, H. Ohno, S. Nagamatsu, et al.
JNK- and I{kappa}B-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro
Am J Physiol Endocrinol Metab, May 1, 2008; 294(5): E898 - E909.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
X. Ruan, F. Zheng, and Y. Guan
PPARs and the kidney in metabolic syndrome
Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1032 - F1047.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
J. R. Miller, P. Siripurkpong, J. Hawes, A. Majdalawieh, H.-S. Ro, and R. S. McLeod
The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPAR{gamma}-dependent and PPAR{gamma}-independent mechanisms
J. Lipid Res., March 1, 2008; 49(3): 550 - 562.
[Abstract] [Full Text] [PDF]


Home page
Toxicol SciHome page
J. Miyawaki, S. Kamei, K. Sakayama, H. Yamamoto, and H. Masuno
4-Tert-Octylphenol Regulates the Differentiation of C3H10T1/2 Cells into Osteoblast and Adipocyte Lineages
Toxicol. Sci., March 1, 2008; 102(1): 82 - 88.
[Abstract] [Full Text] [PDF]


Home page
Stem CellsHome page
S. Karahuseyinoglu, C. Kocaefe, D. Balci, E. Erdemli, and A. Can
Functional Structure of Adipocytes Differentiated from Human Umbilical Cord Stroma-Derived Stem Cells
Stem Cells, March 1, 2008; 26(3): 682 - 691.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
Z. V. Wang and P. E. Scherer
Adiponectin, Cardiovascular Function, and Hypertension
Hypertension, January 1, 2008; 51(1): 8 - 14.
[Full Text] [PDF]


Home page
EndocrinologyHome page
S. Sena, I. R. Rasmussen, A. R. Wende, A. P. McQueen, H. A. Theobald, N. Wilde, R. O. Pereira, S. E. Litwin, J. P. Berger, and E. D. Abel
Cardiac Hypertrophy Caused by Peroxisome Proliferator- Activated Receptor-{gamma} Agonist Treatment Occurs Independently of Changes in Myocardial Insulin Signaling
Endocrinology, December 1, 2007; 148(12): 6047 - 6053.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. L. Brooks, C. M. Trent, C. F. Raetzsch, K. Flurkey, G. Boysen, M. T. Perfetti, Y.-C. Jeong, S. Klebanov, K. B. Patel, V. R. Khodush, et al.
Low Utilization of Circulating Glucose after Food Withdrawal in Snell Dwarf Mice
J. Biol. Chem., November 30, 2007; 282(48): 35069 - 35077.
[Abstract] [Full Text] [PDF]


Home page
Eur J EndocrinolHome page
L. Hojbjerre, M. Rosenzweig, F. Dela, J. M Bruun, and B. Stallknecht
Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects
Eur. J. Endocrinol., November 1, 2007; 157(5): 613 - 623.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
G. Liu, M. Grifman, J. Macdonald, P. Moller, F. Wong-Staal, and Q.-X. Li
Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase
J. Endocrinol., September 1, 2007; 194(3): 569 - 578.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
G. Yuan, X. Chen, Q. Ma, J. Qiao, R. Li, X. Li, S. Li, J. Tang, L. Zhou, H. Song, et al.
C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes
J. Endocrinol., August 1, 2007; 194(2): 275 - 281.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
H. Katagiri, T. Yamada, and Y. Oka
Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals
Circ. Res., July 6, 2007; 101(1): 27 - 39.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J. Lo, L. E. Bernstein, B. Canavan, M. Torriani, M. B. Jackson, R. S. Ahima, and S. K. Grinspoon
Effects of TNF-{alpha} neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E102 - E109.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
Z. V. Wang, T. D. Schraw, J.-Y. Kim, T. Khan, M. W. Rajala, A. Follenzi, and P. E. Scherer
Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention
Mol. Cell. Biol., May 15, 2007; 27(10): 3716 - 3731.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
P. E. Szmitko, H. Teoh, D. J. Stewart, and S. Verma
Adiponectin and cardiovascular disease: state of the art?
Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1655 - H1663.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
L. D. Yee, N. Williams, P. Wen, D. C. Young, J. Lester, M. V. Johnson, W. B. Farrar, M. J. Walker, S. P. Povoski, S. Suster, et al.
Pilot Study of Rosiglitazone Therapy in Women with Breast Cancer: Effects of Short-term Therapy on Tumor Tissue and Serum Markers
Clin. Cancer Res., January 1, 2007; 13(1): 246 - 252.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
M. E. Trujillo and P. E. Scherer
Adipose Tissue-Derived Factors: Impact on Health and Disease
Endocr. Rev., December 1, 2006; 27(7): 762 - 778.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
M. A. Potenza, F. L. Marasciulo, M. Tarquinio, M. J. Quon, and M. Montagnani
Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance
Diabetes, December 1, 2006; 55(12): 3594 - 3603.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
S. L. Gray, E. D. Nora, J. Grosse, M. Manieri, T. Stoeger, G. Medina-Gomez, K. Burling, S. Wattler, A. Russ, G. S.H. Yeo, et al.
Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator-Activated Receptor {gamma} Function (P465L PPAR{gamma}) in Mice.
Diabetes, October 1, 2006; 55(10): 2669 - 2677.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
H. Ghanim, S. Dhindsa, A. Aljada, A. Chaudhuri, P. Viswanathan, and P. Dandona
Low-Dose Rosiglitazone Exerts an Antiinflammatory Effect with an Increase in Adiponectin Independently of Free Fatty Acid Fall and Insulin Sensitization in Obese Type 2 Diabetics
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3553 - 3558.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
R. Bergeron, J. Yao, J. W. Woods, E. I. Zycband, C. Liu, Z. Li, A. Adams, J. P. Berger, B. B. Zhang, D. E. Moller, et al.
Peroxisome Proliferator-Activated Receptor (PPAR)-{alpha} Agonism Prevents the Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats: A Comparison with PPAR{gamma} Agonism
Endocrinology, September 1, 2006; 147(9): 4252 - 4262.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
K. Ota, K. Ito, T. Suzuki, S. Saito, M. Tamura, S.-i. Hayashi, K. Okamura, H. Sasano, and N. Yaegashi
Peroxisome Proliferator-Activated Receptor {gamma} and Growth Inhibition by Its Ligands in Uterine Endometrial Carcinoma.
Clin. Cancer Res., July 15, 2006; 12(14): 4200 - 4208.
[Abstract] [Full Text] [PDF]


Home page
Endocr Relat CancerHome page
A M Lorincz and S Sukumar
Molecular links between obesity and breast cancer.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 279 - 292.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
P. E. Scherer
Adipose Tissue: From Lipid Storage Compartment to Endocrine Organ
Diabetes, June 1, 2006; 55(6): 1537 - 1545.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
K. K. Ong, J. Frystyk, A. Flyvbjerg, C. J. Petry, the Avon Longitudinal Study of Parents and Childre, A. Ness, and D. B. Dunger
Sex-Discordant Associations With Adiponectin Levels and Lipid Profiles in Children.
Diabetes, May 1, 2006; 55(5): 1337 - 1341.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. V. Hertzel, L. A. Smith, A. H. Berg, G. W. Cline, G. I. Shulman, P. E. Scherer, and D. A. Bernlohr
Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E814 - E823.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
S. E Kasim-Karakas, A. Tsodikov, U. Singh, and I. Jialal
Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake.
Am. J. Clinical Nutrition, April 1, 2006; 83(4): 774 - 779.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Kubota, Y. Terauchi, T. Kubota, H. Kumagai, S. Itoh, H. Satoh, W. Yano, H. Ogata, K. Tokuyama, I. Takamoto, et al.
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
J. Biol. Chem., March 31, 2006; 281(13): 8748 - 8755.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. R. Nawrocki, M. W. Rajala, E. Tomas, U. B. Pajvani, A. K. Saha, M. E. Trumbauer, Z. Pang, A. S. Chen, N. B. Ruderman, H. Chen, et al.
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor {gamma} Agonists
J. Biol. Chem., February 3, 2006; 281(5): 2654 - 2660.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
T. Harrity, D. Farrelly, A. Tieman, C. Chu, L. Kunselman, L. Gu, R. Ponticiello, M. Cap, F. Qu, C. Shao, et al.
Muraglitazar, a Novel Dual ({alpha}/{gamma}) Peroxisome Proliferator-Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves {beta}-Cell Function in db/db Mice
Diabetes, January 1, 2006; 55(1): 240 - 248.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
N. Rasouli, A. Yao-Borengasser, L. M. Miles, S. C. Elbein, and P. A. Kern
Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression
Am J Physiol Endocrinol Metab, January 1, 2006; 290(1): E42 - E46.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
S. Z. Duan, C. Y. Ivashchenko, M. W. Russell, D. S. Milstone, and R. M. Mortensen
Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator-Activated Receptor-{gamma} Both Induce Cardiac Hypertrophy in Mice
Circ. Res., August 19, 2005; 97(4): 372 - 379.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
U. Salmenniemi, J. Zacharova, E. Ruotsalainen, I. Vauhkonen, J. Pihlajamaki, S. Kainulainen, K. Punnonen, and M. Laakso
Association of Adiponectin Level and Variants in the Adiponectin Gene with Glucose Metabolism, Energy Expenditure, and Cytokines in Offspring of Type 2 Diabetic Patients
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4216 - 4223.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
D. Dietze-Schroeder, H. Sell, M. Uhlig, M. Koenen, and J. Eckel
Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors
Diabetes, July 1, 2005; 54(7): 2003 - 2011.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
R. Clasen, M. Schupp, A. Foryst-Ludwig, C. Sprang, M. Clemenz, M. Krikov, C. Thone-Reineke, T. Unger, and U. Kintscher
PPAR{gamma}-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin
Hypertension, July 1, 2005; 46(1): 137 - 143.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
K Yamamoto, T Kiyohara, Y Murayama, S Kihara, Y Okamoto, T Funahashi, T Ito, R Nezu, S Tsutsui, J-I Miyagawa, et al.
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease
Gut, June 1, 2005; 54(6): 789 - 796.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
L. Qiao, P. S. MacLean, J. Schaack, D. J. Orlicky, C. Darimont, M. Pagliassotti, J. E. Friedman, and J. Shao
C/EBP{alpha} Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer
Diabetes, June 1, 2005; 54(6): 1744 - 1754.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
T. Kadowaki and T. Yamauchi
Adiponectin and Adiponectin Receptors
Endocr. Rev., May 1, 2005; 26(3): 439 - 451.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
E. S. Kang, S. Y. Park, H. J. Kim, C. W. Ahn, M. Nam, B. S. Cha, S. K. Lim, K. R. Kim, and H. C. Lee
The Influence of Adiponectin Gene Polymorphism on the Rosiglitazone Response in Patients With Type 2 Diabetes
Diabetes Care, May 1, 2005; 28(5): 1139 - 1144.
[Abstract] [Full Text] [PDF]


Home page
J Clin PharmacolHome page
J. A. Wagner, P. J. Larson, S. Weiss, J. L. Miller, T. W. Doebber, M. S. Wu, D. E. Moller, and K. M. Gottesdiener
Individual and Combined Effects of Peroxisome Proliferator-Activated Receptor and {gamma} Agonists, Fenofibrate and Rosiglitazone, on Biomarkers of Lipid and Glucose Metabolism in Healthy Nondiabetic Volunteers
J. Clin. Pharmacol., May 1, 2005; 45(5): 504 - 513.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
K. Inukai, Y. Nakashima, M. Watanabe, N. Takata, T. Sawa, S. Kurihara, T. Awata, and S. Katayama
Regulation of adiponectin receptor gene expression in diabetic mice
Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E876 - E882.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
T. Pischon, C. J Girman, N. Rifai, G. S Hotamisligil, and E. B Rimm
Association between dietary factors and plasma adiponectin concentrations in men
Am. J. Clinical Nutrition, April 1, 2005; 81(4): 780 - 786.
[Abstract] [Full Text] [PDF]


Home page
Exp. Biol. Med.Home page
C. L. Winter, J. S. Lange, M. G. Davis, G. S. Gerwe, T. R. Downs, K. G. Peters, and B. Kasibhatla
A Nonspecific Phosphotyrosine Phosphatase Inhibitor, Bis(maltolato)oxovanadium(IV), Improves Glucose Tolerance and Prevents Diabetes in Zucker Diabetic Fatty Rats
Experimental Biology and Medicine, March 1, 2005; 230(3): 207 - 216.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
F. Kawasaki, M. Matsuda, Y. Kanda, H. Inoue, and K. Kaku
Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice
Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E510 - E518.
[Abstract] [Full Text] [PDF]


Home page
Reproductive SciencesHome page
V. Sepilian and M. Nagamani
Adiponectin Levels in Women With Polycystic Ovary Syndrome and Severe Insulin Resistance
Reproductive Sciences, February 1, 2005; 12(2): 129 - 134.
[Abstract] [PDF]


Home page
EndocrinologyHome page
K. A. Al-Regaiey, M. M. Masternak, M. Bonkowski, L. Sun, and A. Bartke
Long-Lived Growth Hormone Receptor Knockout Mice: Interaction of Reduced Insulin-Like Growth Factor I/Insulin Signaling and Caloric Restriction
Endocrinology, February 1, 2005; 146(2): 851 - 860.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
A. M. Delaigle, J.-C. Jonas, I. B. Bauche, O. Cornu, and S. M. Brichard
Induction of Adiponectin in Skeletal Muscle by Inflammatory Cytokines: in Vivo and in Vitro Studies
Endocrinology, December 1, 2004; 145(12): 5589 - 5597.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
Y. Guan
Peroxisome Proliferator-Activated Receptor Family and Its Relationship to Renal Complications of the Metabolic Syndrome
J. Am. Soc. Nephrol., November 1, 2004; 15(11): 2801 - 2815.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
M. Z. Strowski, Z. Li, D. Szalkowski, X. Shen, X.-M. Guan, S. Juttner, D. E. Moller, and B. B. Zhang
Small-Molecule Insulin Mimetic Reduces Hyperglycemia and Obesity in a Nongenetic Mouse Model of Type 2 Diabetes
Endocrinology, November 1, 2004; 145(11): 5259 - 5268.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
C. R. Bruce and D. J. Dyck
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-{alpha}
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E616 - E621.
[Abstract] [Full Text] [PDF]


Home page
NEJMHome page
H. Yki-Jarvinen
Thiazolidinediones
N. Engl. J. Med., September 9, 2004; 351(11): 1106 - 1118.
[Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
M.-L. Delporte, S. A. El Mkadem, M. Quisquater, and S. M. Brichard
Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E446 - E453.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
M. Tiikkainen, A.-M. Hakkinen, E. Korsheninnikova, T. Nyman, S. Makimattila, and H. Yki-Jarvinen
Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
Diabetes, August 1, 2004; 53(8): 2169 - 2176.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
G. W. Wong, J. Wang, C. Hug, T.-S. Tsao, and H. F. Lodish
A family of Acrp30/adiponectin structural and functional paralogs
PNAS, July 13, 2004; 101(28): 10302 - 10307.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J. Sutinen, K. Kannisto, E. Korsheninnikova, R. M. Fisher, E. Ehrenborg, T. Nyman, A. Virkamaki, T. Funahashi, Y. Matsuzawa, H. Vidal, et al.
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E941 - E949.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
S. D. Patel, M. W. Rajala, L. Rossetti, P. E. Scherer, and L. Shapiro
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones
Science, May 21, 2004; 304(5674): 1154 - 1158.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Q. Shen, G. W. Cline, G. I. Shulman, M. D. Leibowitz, and P. J. A. Davies
Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice
J. Biol. Chem., May 7, 2004; 279(19): 19721 - 19731.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
M. Hazel, R. C. Cooksey, D. Jones, G. Parker, J. L. Neidigh, B. Witherbee, E. A. Gulve, and D. A. McClain
Activation of the Hexosamine Signaling Pathway in Adipose Tissue Results in Decreased Serum Adiponectin and Skeletal Muscle Insulin Resistance
Endocrinology, May 1, 2004; 145(5): 2118 - 2128.
[Abstract] [Full Text] [PDF]


Home page
JAMAHome page
T. Pischon, C. J. Girman, G. S. Hotamisligil, N. Rifai, F. B. Hu, and E. B. Rimm
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
JAMA, April 14, 2004; 291(14): 1730 - 1737.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
T. Tagami, N. Satoh, T. Usui, K. Yamada, A. Shimatsu, and H. Kuzuya
Adiponectin in Anorexia Nervosa and Bulimia Nervosa
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1833 - 1837.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
U. B. Pajvani, M. Hawkins, T. P. Combs, M. W. Rajala, T. Doebber, J. P. Berger, J. A. Wagner, M. Wu, A. Knopps, A. H. Xiang, et al.
Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity
J. Biol. Chem., March 26, 2004; 279(13): 12152 - 12162.
[Abstract] [Full Text] [PDF]


Home page
J ANIM SCIHome page
J. L. Miner
The adipocyte as an endocrine cell
J Anim Sci, March 1, 2004; 82(3): 935 - 941.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Chen, T. Zhang, and B. L. G. Nyomba
Insulin resistance of gluconeogenic pathways in neonatal rats after prenatal ethanol exposure
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R554 - R559.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
W. B. Kinlaw and B. Marsh
Adiponectin and HIV-Lipodystrophy: Taking HAART
Endocrinology, February 1, 2004; 145(2): 484 - 486.
[Full Text] [PDF]


Home page
DiabetesHome page
L.-J. Ma, S.-L. Mao, K. L. Taylor, T. Kanjanabuch, Y. Guan, Y. Zhang, N. J. Brown, L. L. Swift, O. P. McGuinness, D. H. Wasserman, et al.
Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1
Diabetes, February 1, 2004; 53(2): 336 - 346.
[Abstract] [Full Text]


Home page
DiabetesHome page
P. J. Havel
Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism
Diabetes, February 1, 2004; 53(90001): S143 - 151.
[Abstract] [Full Text]


Home page
HypertensionHome page
W. A. Hsueh and D. Bruemmer
Peroxisome Proliferator-Activated Receptor {gamma}: Implications for Cardiovascular Disease
Hypertension, February 1, 2004; 43(2): 297 - 305.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
M. Muurling, A. M. van den Hoek, R. P. Mensink, H. Pijl, J. A. Romijn, L. M. Havekes, and P. J. Voshol
Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance
J. Lipid Res., January 1, 2004; 45(1): 9 - 16.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
T. P. Combs, U. B. Pajvani, A. H. Berg, Y. Lin, L. A. Jelicks, M. Laplante, A. R. Nawrocki, M. W. Rajala, Albert. F. Parlow, L. Cheeseboro, et al.
A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity
Endocrinology, January 1, 2004; 145(1): 367 - 383.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
W. He, Y. Barak, A. Hevener, P. Olson, D. Liao, J. Le, M. Nelson, E. Ong, J. M. Olefsky, and R. M. Evans
Adipose-specific peroxisome proliferator-activated receptor {gamma} knockout causes insulin resistance in fat and liver but not in muscle
PNAS, December 23, 2003; 100(26): 15712 - 15717.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
R. H. Unger
Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome
Endocrinology, December 1, 2003; 144(12): 5159 - 5165.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
A. Minami, M. Iseki, K. Kishi, M. Wang, M. Ogura, N. Furukawa, S. Hayashi, M. Yamada, T. Obata, Y. Takeshita, et al.
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice
Diabetes, November 1, 2003; 52(11): 2657 - 2665.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. S. Lihn, B. Richelsen, S. B. Pedersen, S. B. Haugaard, G. S. Rathje, S. Madsbad, and O. Andersen
Increased expression of TNF-{alpha}, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1072 - E1080.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
C. Wang, N. Pattabiraman, J. N. Zhou, M. Fu, T. Sakamaki, C. Albanese, Z. Li, K. Wu, J. Hulit, P. Neumeister, et al.
Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor {gamma} Expression and Transactivation
Mol. Cell. Biol., September 1, 2003; 23(17): 6159 - 6173.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
M. W. Rajala and P. E. Scherer
Minireview: The Adipocyte--At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Endocrinology, September 1, 2003; 144(9): 3765 - 3773.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bruun, A. S. Lihn, C. Verdich, S. B. Pedersen, S. Toubro, A. Astrup, and B. Richelsen
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
Am J Physiol Endocrinol Metab, September 1, 2003; 285(3): E527 - E533.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
M. Chandran, S. A. Phillips, T. Ciaraldi, and R. R. Henry
Adiponectin: More Than Just Another Fat Cell Hormone?
Diabetes Care, August 1, 2003; 26(8): 2442 - 2450.
[Full Text] [PDF]


Home page
FASEB J.Home page
P.-A. JANSSON, F. PELLME, A. HAMMARSTEDT, M. SANDQVIST, H. BREKKE, K. CAIDAHL, M. FORSBERG, R. VOLKMANN, E. CARVALHO, T. FUNAHASHI, et al.
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin
FASEB J, August 1, 2003; 17(11): 1434 - 1440.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
S. Nagasaka, A. Taniguchi, Y. Aiso, T. Yatagai, T. Nakamura, Y. Nakai, M. Fukushima, A. Kuroe, and S. Ishibashi
Effect of Glimepiride on Serum Adiponectin Level in Subjects With Type 2 Diabetes
Diabetes Care, July 1, 2003; 26(7): 2215 - 2216.
[Full Text] [PDF]


Home page
DiabetesHome page
M. Iwaki, M. Matsuda, N. Maeda, T. Funahashi, Y. Matsuzawa, M. Makishima, and I. Shimomura
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
Diabetes, July 1, 2003; 52(7): 1655 - 1663.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
M. Furuhashi, N. Ura, K. Higashiura, H. Murakami, M. Tanaka, N. Moniwa, D. Yoshida, and K. Shimamoto
Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
Hypertension, July 1, 2003; 42(1): 76 - 81.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
M. Gurnell, D. B. Savage, V. K. K. Chatterjee, and S. O'Rahilly
The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor {gamma} and Its Therapeutic Modulation
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2412 - 2421.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
Q. Tong, J.-L. Sankale, C. M. Hadigan, G. Tan, E. S. Rosenberg, P. J. Kanki, S. K. Grinspoon, and G. S. Hotamisligil
Regulation of Adiponectin in Human Immunodeficiency Virus-Infected Patients: Relationship to Body Composition and Metabolic Indices
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1559 - 1564.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
D. B. Savage, G. D. Tan, C. L. Acerini, S. A. Jebb, M. Agostini, M. Gurnell, R. L. Williams, A. M. Umpleby, E. L. Thomas, J. D. Bell, et al.
Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-{gamma}
Diabetes, April 1, 2003; 52(4): 910 - 917.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
S. Engeli, M. Feldpausch, K. Gorzelniak, F. Hartwig, U. Heintze, J. Janke, M. Mohlig, A. F.H. Pfeiffer, F. C. Luft, and A. M. Sharma
Association Between Adiponectin and Mediators of Inflammation in Obese Women
Diabetes, April 1, 2003; 52(4): 942 - 947.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
U. B. Pajvani, X. Du, T. P. Combs, A. H. Berg, M. W. Rajala, T. Schulthess, J. Engel, M. Brownlee, and P. E. Scherer
Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin. IMPLICATIONS FOR METABOLIC REGULATION AND BIOACTIVITY
J. Biol. Chem., March 7, 2003; 278(11): 9073 - 9085.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
S. A. Phillips, T. P. Ciaraldi, A. P.S. Kong, R. Bandukwala, V. Aroda, L. Carter, S. Baxi, S. R. Mudaliar, and R. R. Henry
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
Diabetes, March 1, 2003; 52(3): 667 - 674.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J.-M. Ye, M. A. Iglesias, D. G. Watson, B. Ellis, L. Wood, P. B. Jensen, R. V. Sorensen, P. J. Larsen, G. J. Cooney, K. Wassermann, et al.
PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E531 - E540.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
L. Chen and B. L. G. Nyomba
Glucose Intolerance and Resistin Expression in Rat Offspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet
Endocrinology, February 1, 2003; 144(2): 500 - 508.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
O. Tschritter, A. Fritsche, C. Thamer, M. Haap, F. Shirkavand, S. Rahe, H. Staiger, E. Maerker, H. Haring, and M. Stumvoll
Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism
Diabetes, February 1, 2003; 52(2): 239 - 243.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
T. P. Combs, A. H. Berg, M. W. Rajala, S. Klebanov, P. Iyengar, J. C. Jimenez-Chillaron, M. E. Patti, S. L. Klein, R. S. Weinstein, and P. E. Scherer
Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin
Diabetes, February 1, 2003; 52(2): 268 - 276.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2002 by The Endocrine Society