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Endocrinology Vol. 143, No. 3 998-1007
Copyright © 2002 by The Endocrine Society

INSULIN-GLUCAGON-GI PEPTIDES-DIABETES MELLITUS

Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPAR{gamma} Agonists: A Potential Mechanism of Insulin Sensitization

Terry P. Combs, John A. Wagner, Joel Berger, Tom Doebber, Wen-Jun Wang, Bei B. Zhang, Michael Tanen, Anders H Berg, Stephen O’Rahilly, David B. Savage, Krishna Chatterjee, Stuart Weiss, Patrick J. Larson, Keith M. Gottesdiener, Barry J. Gertz, Maureen J. Charron, Philipp E. Scherer and David E. Moller

Departments of Cell Biology (T.P.C., A.H.B., P.E.S.) and Biochemistry (W.-H.W., M.J.C.) Albert Einstein College of Medicine, Bronx, New York 10461; Departments of Molecular Endocrinology (J.B., T.D., B.B.Z., M.T., D.E.M.), Clinical Pharmacology (J.A.W., K.M.G., B.J.G.), and Clinical Biostatistics and Research Data Systems (P.J.L.), Merck Research Laboratories, Rahway, New Jersey 07065; Departments of Medicine and Clinical Biochemistry (S.O’R., D.B.S., K.C.), University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 2QQ, United Kingdom; and San Diego Endocrine and Metabolic Clinic (S.W.), San Diego, California 92108

Address all correspondence and requests for reprints to: Philipp Scherer, Albert Einstein College of Medicine, Chanin 414, Department of Cell Biology, 1300 Morris Park Avenue, Bronx, New York 10461. E-mail: . scherer{at}aecom.yu.edu

Adipocyte complement-related protein of 30 kDa (Acrp30, adiponectin, or AdipoQ) is a fat-derived secreted protein that circulates in plasma. Adipose tissue expression of Acrp30 is lower in insulin-resistant states and it is implicated in the regulation of in vivo insulin sensitivity. Here we have characterized the ability of PPAR{gamma} agonists to modulate Acrp30 expression. After chronic treatment of obese-diabetic (db/db) mice with PPAR{gamma} agonists (11 d), mean plasma Acrp30 protein levels increased (>3x). Similar effects were noted in a nongenetic type 2 diabetes model (fat-fed and low-dose streptozotocin-treated mice). In contrast, treatment of mice (db/db or fat-fed) with metformin or a PPAR{alpha} agonist did not affect plasma Acrp30 protein levels. In a cohort of normal human subjects, 14-d treatment with rosiglitazone also produced a 130% increase in circulating Acrp30 levels vs. placebo. In addition, circulating Acrp30 levels were suppressed 5-fold in patients with severe insulin resistance in association with dominant-negative PPAR{gamma} mutations. Thus, induction of adipose tissue Acrp30 expression and consequent increases in circulating Acrp30 levels represents a novel potential mechanism for PPAR{gamma}-mediated enhancement of whole-body insulin sensitivity. Furthermore, Acrp30 is likely to be a biomarker of in vivo PPAR{gamma} activation.




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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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A. V. Hertzel, L. A. Smith, A. H. Berg, G. W. Cline, G. I. Shulman, P. E. Scherer, and D. A. Bernlohr
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression
Am J Physiol Endocrinol Metab, January 1, 2006; 290(1): E42 - E46.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Z. Duan, C. Y. Ivashchenko, M. W. Russell, D. S. Milstone, and R. M. Mortensen
Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator-Activated Receptor-{gamma} Both Induce Cardiac Hypertrophy in Mice
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[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors
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Home page
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Home page
 GutHome page
K Yamamoto, T Kiyohara, Y Murayama, S Kihara, Y Okamoto, T Funahashi, T Ito, R Nezu, S Tsutsui, J-I Miyagawa, et al.
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease
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Home page
 DiabetesHome page
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C/EBP{alpha} Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer
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[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. Kadowaki and T. Yamauchi
Adiponectin and Adiponectin Receptors
Endocr. Rev., May 1, 2005; 26(3): 439 - 451.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
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Home page
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Individual and Combined Effects of Peroxisome Proliferator-Activated Receptor and {gamma} Agonists, Fenofibrate and Rosiglitazone, on Biomarkers of Lipid and Glucose Metabolism in Healthy Nondiabetic Volunteers
J. Clin. Pharmacol., May 1, 2005; 45(5): 504 - 513.
[Abstract] [Full Text] [PDF]

Home page
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Regulation of adiponectin receptor gene expression in diabetic mice
Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E876 - E882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
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Association between dietary factors and plasma adiponectin concentrations in men
Am. J. Clinical Nutrition, April 1, 2005; 81(4): 780 - 786.
[Abstract] [Full Text] [PDF]

Home page
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 Am. J. Physiol. Endocrinol. Metab.Home page
C. R. Bruce and D. J. Dyck
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-{alpha}
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E616 - E621.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
H. Yki-Jarvinen
Thiazolidinediones
N. Engl. J. Med., September 9, 2004; 351(11): 1106 - 1118.
[Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
M.-L. Delporte, S. A. El Mkadem, M. Quisquater, and S. M. Brichard
Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E446 - E453.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
M. Tiikkainen, A.-M. Hakkinen, E. Korsheninnikova, T. Nyman, S. Makimattila, and H. Yki-Jarvinen
Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
Diabetes, August 1, 2004; 53(8): 2169 - 2176.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G. W. Wong, J. Wang, C. Hug, T.-S. Tsao, and H. F. Lodish
A family of Acrp30/adiponectin structural and functional paralogs
PNAS, July 13, 2004; 101(28): 10302 - 10307.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
J. Sutinen, K. Kannisto, E. Korsheninnikova, R. M. Fisher, E. Ehrenborg, T. Nyman, A. Virkamaki, T. Funahashi, Y. Matsuzawa, H. Vidal, et al.
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E941 - E949.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
S. D. Patel, M. W. Rajala, L. Rossetti, P. E. Scherer, and L. Shapiro
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones
Science, May 21, 2004; 304(5674): 1154 - 1158.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
Q. Shen, G. W. Cline, G. I. Shulman, M. D. Leibowitz, and P. J. A. Davies
Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice
J. Biol. Chem., May 7, 2004; 279(19): 19721 - 19731.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
M. Hazel, R. C. Cooksey, D. Jones, G. Parker, J. L. Neidigh, B. Witherbee, E. A. Gulve, and D. A. McClain
Activation of the Hexosamine Signaling Pathway in Adipose Tissue Results in Decreased Serum Adiponectin and Skeletal Muscle Insulin Resistance
Endocrinology, May 1, 2004; 145(5): 2118 - 2128.
[Abstract] [Full Text] [PDF]

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 JAMAHome page
T. Pischon, C. J. Girman, G. S. Hotamisligil, N. Rifai, F. B. Hu, and E. B. Rimm
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
JAMA, April 14, 2004; 291(14): 1730 - 1737.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
T. Tagami, N. Satoh, T. Usui, K. Yamada, A. Shimatsu, and H. Kuzuya
Adiponectin in Anorexia Nervosa and Bulimia Nervosa
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1833 - 1837.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
U. B. Pajvani, M. Hawkins, T. P. Combs, M. W. Rajala, T. Doebber, J. P. Berger, J. A. Wagner, M. Wu, A. Knopps, A. H. Xiang, et al.
Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity
J. Biol. Chem., March 26, 2004; 279(13): 12152 - 12162.
[Abstract] [Full Text] [PDF]

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 J ANIM SCIHome page
J. L. Miner
The adipocyte as an endocrine cell
J Anim Sci, March 1, 2004; 82(3): 935 - 941.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Chen, T. Zhang, and B. L. G. Nyomba
Insulin resistance of gluconeogenic pathways in neonatal rats after prenatal ethanol exposure
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2004; 286(3): R554 - R559.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
W. B. Kinlaw and B. Marsh
Adiponectin and HIV-Lipodystrophy: Taking HAART
Endocrinology, February 1, 2004; 145(2): 484 - 486.
[Full Text] [PDF]

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 DiabetesHome page
L.-J. Ma, S.-L. Mao, K. L. Taylor, T. Kanjanabuch, Y. Guan, Y. Zhang, N. J. Brown, L. L. Swift, O. P. McGuinness, D. H. Wasserman, et al.
Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1
Diabetes, February 1, 2004; 53(2): 336 - 346.
[Abstract] [Full Text]

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 DiabetesHome page
P. J. Havel
Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism
Diabetes, February 1, 2004; 53(90001): S143 - 151.
[Abstract] [Full Text]

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 HypertensionHome page
W. A. Hsueh and D. Bruemmer
Peroxisome Proliferator-Activated Receptor {gamma}: Implications for Cardiovascular Disease
Hypertension, February 1, 2004; 43(2): 297 - 305.
[Abstract] [Full Text] [PDF]

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 J. Lipid Res.Home page
M. Muurling, A. M. van den Hoek, R. P. Mensink, H. Pijl, J. A. Romijn, L. M. Havekes, and P. J. Voshol
Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance
J. Lipid Res., January 1, 2004; 45(1): 9 - 16.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
T. P. Combs, U. B. Pajvani, A. H. Berg, Y. Lin, L. A. Jelicks, M. Laplante, A. R. Nawrocki, M. W. Rajala, Albert. F. Parlow, L. Cheeseboro, et al.
A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity
Endocrinology, January 1, 2004; 145(1): 367 - 383.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
W. He, Y. Barak, A. Hevener, P. Olson, D. Liao, J. Le, M. Nelson, E. Ong, J. M. Olefsky, and R. M. Evans
Adipose-specific peroxisome proliferator-activated receptor {gamma} knockout causes insulin resistance in fat and liver but not in muscle
PNAS, December 23, 2003; 100(26): 15712 - 15717.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
R. H. Unger
Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome
Endocrinology, December 1, 2003; 144(12): 5159 - 5165.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
A. Minami, M. Iseki, K. Kishi, M. Wang, M. Ogura, N. Furukawa, S. Hayashi, M. Yamada, T. Obata, Y. Takeshita, et al.
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice
Diabetes, November 1, 2003; 52(11): 2657 - 2665.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
A. S. Lihn, B. Richelsen, S. B. Pedersen, S. B. Haugaard, G. S. Rathje, S. Madsbad, and O. Andersen
Increased expression of TNF-{alpha}, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1072 - E1080.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
C. Wang, N. Pattabiraman, J. N. Zhou, M. Fu, T. Sakamaki, C. Albanese, Z. Li, K. Wu, J. Hulit, P. Neumeister, et al.
Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor {gamma} Expression and Transactivation
Mol. Cell. Biol., September 1, 2003; 23(17): 6159 - 6173.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
M. W. Rajala and P. E. Scherer
Minireview: The Adipocyte--At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Endocrinology, September 1, 2003; 144(9): 3765 - 3773.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bruun, A. S. Lihn, C. Verdich, S. B. Pedersen, S. Toubro, A. Astrup, and B. Richelsen
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
Am J Physiol Endocrinol Metab, September 1, 2003; 285(3): E527 - E533.
[Abstract] [Full Text] [PDF]

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 Diabetes CareHome page
M. Chandran, S. A. Phillips, T. Ciaraldi, and R. R. Henry
Adiponectin: More Than Just Another Fat Cell Hormone?
Diabetes Care, August 1, 2003; 26(8): 2442 - 2450.
[Full Text] [PDF]

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 FASEB J.Home page
P.-A. JANSSON, F. PELLME, A. HAMMARSTEDT, M. SANDQVIST, H. BREKKE, K. CAIDAHL, M. FORSBERG, R. VOLKMANN, E. CARVALHO, T. FUNAHASHI, et al.
A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin
FASEB J, August 1, 2003; 17(11): 1434 - 1440.
[Abstract] [Full Text] [PDF]

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 Diabetes CareHome page
S. Nagasaka, A. Taniguchi, Y. Aiso, T. Yatagai, T. Nakamura, Y. Nakai, M. Fukushima, A. Kuroe, and S. Ishibashi
Effect of Glimepiride on Serum Adiponectin Level in Subjects With Type 2 Diabetes
Diabetes Care, July 1, 2003; 26(7): 2215 - 2216.
[Full Text] [PDF]

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 DiabetesHome page
M. Iwaki, M. Matsuda, N. Maeda, T. Funahashi, Y. Matsuzawa, M. Makishima, and I. Shimomura
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
Diabetes, July 1, 2003; 52(7): 1655 - 1663.
[Abstract] [Full Text] [PDF]

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 HypertensionHome page
M. Furuhashi, N. Ura, K. Higashiura, H. Murakami, M. Tanaka, N. Moniwa, D. Yoshida, and K. Shimamoto
Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
Hypertension, July 1, 2003; 42(1): 76 - 81.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
M. Gurnell, D. B. Savage, V. K. K. Chatterjee, and S. O'Rahilly
The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor {gamma} and Its Therapeutic Modulation
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2412 - 2421.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
Q. Tong, J.-L. Sankale, C. M. Hadigan, G. Tan, E. S. Rosenberg, P. J. Kanki, S. K. Grinspoon, and G. S. Hotamisligil
Regulation of Adiponectin in Human Immunodeficiency Virus-Infected Patients: Relationship to Body Composition and Metabolic Indices
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1559 - 1564.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
D. B. Savage, G. D. Tan, C. L. Acerini, S. A. Jebb, M. Agostini, M. Gurnell, R. L. Williams, A. M. Umpleby, E. L. Thomas, J. D. Bell, et al.
Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-{gamma}
Diabetes, April 1, 2003; 52(4): 910 - 917.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
S. Engeli, M. Feldpausch, K. Gorzelniak, F. Hartwig, U. Heintze, J. Janke, M. Mohlig, A. F.H. Pfeiffer, F. C. Luft, and A. M. Sharma
Association Between Adiponectin and Mediators of Inflammation in Obese Women
Diabetes, April 1, 2003; 52(4): 942 - 947.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
U. B. Pajvani, X. Du, T. P. Combs, A. H. Berg, M. W. Rajala, T. Schulthess, J. Engel, M. Brownlee, and P. E. Scherer
Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin. IMPLICATIONS FOR METABOLIC REGULATION AND BIOACTIVITY
J. Biol. Chem., March 7, 2003; 278(11): 9073 - 9085.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. A. Phillips, T. P. Ciaraldi, A. P.S. Kong, R. Bandukwala, V. Aroda, L. Carter, S. Baxi, S. R. Mudaliar, and R. R. Henry
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
Diabetes, March 1, 2003; 52(3): 667 - 674.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
J.-M. Ye, M. A. Iglesias, D. G. Watson, B. Ellis, L. Wood, P. B. Jensen, R. V. Sorensen, P. J. Larsen, G. J. Cooney, K. Wassermann, et al.
PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E531 - E540.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
L. Chen and B. L. G. Nyomba
Glucose Intolerance and Resistin Expression in Rat Offspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet
Endocrinology, February 1, 2003; 144(2): 500 - 508.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
O. Tschritter, A. Fritsche, C. Thamer, M. Haap, F. Shirkavand, S. Rahe, H. Staiger, E. Maerker, H. Haring, and M. Stumvoll
Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism
Diabetes, February 1, 2003; 52(2): 239 - 243.
[Abstract] [Full Text] [PDF]

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 DiabetesHome page
T. P. Combs, A. H. Berg, M. W. Rajala, S. Klebanov, P. Iyengar, J. C. Jimenez-Chillaron, M. E. Patti, S. L. Klein, R. S. Weinstein, and P. E. Scherer
Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin
Diabetes, February 1, 2003; 52(2): 268 - 276.
[Abstract] [Full Text] [PDF]


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