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Growth Hormone Rapidly Induces Resistin Gene Expression in White Adipose Tissue of Spontaneous Dwarf (SDR) Rats

Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St Leonards, NSW, Australia (P.J.D.D., D.M., F.M., R.C.B.); Department of Intensive Care Medicine, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium (D.M.)

Growth hormone is an important regulator of metabolism; both acromegaly and GH therapy in GH-deficiency are associated with a tendency towards insulin-resistance and loss of adiposity. A possible mediator of these effects is the recently identified white adipose tissue (WAT)-derived factor resistin that has been shown to impair glucose tolerance and inhibit adipocyte differentiation. We found that WAT resistin gene expression was significantly suppressed in GH-deficient (SDR) rats compared with their Sprague-Dawley background strain. However, within 4h of treatment of SDRs with a bolus of rhGH (1.5 mg/kg) there was a significant 150–170% increase in WAT resistin mRNA. Moreover, 24h continuous infusion of recombinant human GH (1 mg/kg/day) caused marked increases in epididymal and subcutaneous WAT resistin of 720% and 950%, respectively, compared to controls. By 48h of infusion these values had fallen to 510% and 330%. Infusion of porcine GH (1 mg/kg/day) had a similar inductive effect on WAT resistin mRNA. Our data demonstrate an unexpected marked, rapid and sustained up-regulattion of resistin by GH. This may indicate a role for resistin in GH-dependent metabolic and differentiative effects in WAT.

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