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Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030
Address all correspondence and requests for reprints to: Bert W. O’Malley, M.D., Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030. E-mail: . berto{at}bcm.tmc.edu
Nuclear receptors (NRs) regulate the expression of target genes in response to activation by steroid hormones and other ligands, as well as a variety of other signaling pathways. NR coactivators are defined as cellular factors recruited by activated NRs that complement their function as mediators of the cellular response to endocrine signals. In this review, we will focus upon advances in our understanding of the function of coactivators as their characterization has progressed from mechanistic studies to an exploration of their biological roles in living animals.
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R. O'Lone, M. C. Frith, E. K. Karlsson, and U. Hansen Genomic Targets of Nuclear Estrogen Receptors Mol. Endocrinol., August 1, 2004; 18(8): 1859 - 1875. [Abstract] [Full Text] [PDF]
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Y. A. Elhaji, J. Hui Wu, B. Gottlieb, L. K. Beitel, C. Alvarado, G. Batist, and M. A. Trifiro An Examination of How Different Mutations at Arginine 855 of the Androgen Receptor Result in Different Androgen Insensitivity Phenotypes Mol. Endocrinol., August 1, 2004; 18(8): 1876 - 1886. [Abstract] [Full Text] [PDF]
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M. A. Iannone, C. A. Simmons, S. H. Kadwell, D. L. Svoboda, D. E. Vanderwall, S.-J. Deng, T. G. Consler, J. Shearin, J. G. Gray, and K. H. Pearce Correlation between in Vitro Peptide Binding Profiles and Cellular Activities for Estrogen Receptor-Modulating Compounds Mol. Endocrinol., May 1, 2004; 18(5): 1064 - 1081. [Abstract] [Full Text] [PDF]
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 T. Kajitani, T. Mizutani, K. Yamada, T. Yazawa, T. Sekiguchi, M. Yoshino, H. Kawata, and K. Miyamoto Cloning and Characterization of Granulosa Cell High-Mobility Group (HMG)-Box Protein-1, a Novel HMG-Box Transcriptional Regulator Strongly Expressed in Rat Ovarian Granulosa Cells Endocrinology, May 1, 2004; 145(5): 2307 - 2318. [Abstract] [Full Text] [PDF]
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B. Herzog, R. K. Hall, X. L. Wang, M. Waltner-Law, and D. K. Granner Peroxisome Proliferator-Activated Receptor {gamma} Coactivator-1{alpha}, as a Transcription Amplifier, Is Not Essential for Basal and Hormone-Induced Phosphoenolpyruvate Carboxykinase Gene Expression Mol. Endocrinol., April 1, 2004; 18(4): 807 - 819. [Abstract] [Full Text] [PDF]
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C. Elbi, D. A. Walker, G. Romero, W. P. Sullivan, D. O. Toft, G. L. Hager, and D. B. DeFranco Molecular chaperones function as steroid receptor nuclear mobility factors PNAS, March 2, 2004; 101(9): 2876 - 2881. [Abstract] [Full Text] [PDF]
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L. Wang, C.-L. Hsu, J. Ni, P.-H. Wang, S. Yeh, P. Keng, and C. Chang Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells Mol. Cell. Biol., March 1, 2004; 24(5): 2202 - 2213. [Abstract] [Full Text] [PDF]
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D. Obradovic, M. Tirard, Zs. Nemethy, O. Hirsch, H. Gronemeyer, and O. F. X. Almeida DAXX, FLASH, and FAF-1 Modulate Mineralocorticoid and Glucocorticoid Receptor-Mediated Transcription in Hippocampal Cells--Toward a Basis for the Opposite Actions Elicited by Two Nuclear Receptors? Mol. Pharmacol., March 1, 2004; 65(3): 761 - 769. [Abstract] [Full Text] [PDF]
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C. A. Lange Making Sense of Cross-Talk between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word? Mol. Endocrinol., February 1, 2004; 18(2): 269 - 278. [Abstract] [Full Text] [PDF]
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M. H. Faulds, H. Olsen, L. A. Helguero, J.-A. Gustafsson, and L.-A. Haldosen Estrogen Receptor Functional Activity Changes during Differentiation of Mammary Epithelial Cells Mol. Endocrinol., February 1, 2004; 18(2): 412 - 421. [Abstract] [Full Text] [PDF]
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G. Sathya, C.-y. Chang, D. Kazmin, C. E. Cook, and D. P. McDonnell Pharmacological Uncoupling of Androgen Receptor-mediated Prostate Cancer Cell Proliferation and Prostate-specific Antigen Secretion Cancer Res., November 15, 2003; 63(22): 8029 - 8036. [Abstract] [Full Text] [PDF]
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G. Zhou, Y. Hashimoto, I. Kwak, S. Y. Tsai, and M.-J. Tsai Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth Mol. Cell. Biol., November 1, 2003; 23(21): 7742 - 7755. [Abstract] [Full Text] [PDF]
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K. De Bosscher, W. Vanden Berghe, and G. Haegeman The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression Endocr. Rev., August 1, 2003; 24(4): 488 - 522. [Abstract] [Full Text] [PDF]
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S. Albert, S. Gaudan, H. Knigge, A. Raetsch, A. Delgado, B. Huhse, H. Kirsch, M. Albers, D. Rebholz-Schuhmann, and M. Koegl Computer-Assisted Generation of a Protein-Interaction Database for Nuclear Receptors Mol. Endocrinol., August 1, 2003; 17(8): 1555 - 1567. [Abstract] [Full Text] [PDF]
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J. M. Maglich, J. A. Caravella, M. H. Lambert, T. M. Willson, J. T. Moore, and L. Ramamurthy The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily Nucleic Acids Res., July 15, 2003; 31(14): 4051 - 4058. [Abstract] [Full Text] [PDF]
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J. Frasor, D. H. Barnett, J. M. Danes, R. Hess, A. F. Parlow, and B. S. Katzenellenbogen Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) {alpha} Activity by ER{beta} in the Uterus Endocrinology, July 1, 2003; 144(7): 3159 - 3166. [Abstract] [Full Text] [PDF]
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A. L. M. Sutton and P. N. MacDonald Vitamin D: More Than a "Bone-a-Fide" Hormone Mol. Endocrinol., May 1, 2003; 17(5): 777 - 791. [Abstract] [Full Text] [PDF]
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J. Liu, K. S. Knappenberger, H. Kack, G. Andersson, E. Nilsson, C. Dartsch, and C. W. Scott A Homogeneous in Vitro Functional Assay for Estrogen Receptors: Coactivator Recruitment Mol. Endocrinol., March 1, 2003; 17(3): 346 - 355. [Abstract] [Full Text] [PDF]
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