help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsai, S.-J.
Right arrow Articles by Wing, L.-Y. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsai, S.-J.
Right arrow Articles by Wing, L.-Y. C.
Endocrinology Vol. 143, No. 7 2715-2721
Copyright © 2002 by The Endocrine Society

GROWTH FACTORS-CYTOKINES-ONCOGENES

Fibroblast Growth Factor-9 Is an Endometrial Stromal Growth Factor

Shaw-Jenq Tsai, Meng-Hsing Wu, Hsiu-Mei Chen, Pei-Chin Chuang and Lih-Yuh C. Wing

Departments of Physiology (S.-J.T., H.-M.C., P.-C.C., L.-Y.W.) and Obstetrics & Gynecology (M.-H.W.), National Cheng Kung University Medical College, Tainan 70101, Taiwan, Republic of China

Address all correspondence and requests for reprints to: Lih-Yuh C. Wing, Ph.D., Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China. E-mail: . wing{at}mail.ncku.edu.tw

Fibroblast growth factor-9 (FGF-9) is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate. In this study, we found that FGF-9 was expressed at high levels in normal uterine endometrium, especially during the late proliferative phase, which is coincident with the rise of estradiol and the time of uterine endometrial proliferation. Using quantitative RT-PCR analysis, we found that FGF-9 mRNA was expressed primarily by endometrial stromal cells. High affinity receptors of FGF-9 were detected in both epithelial and stromal cells but with distinct patterns. FGFR2IIIc and FGFR3IIIc are abundant in endometrial stromal cell. FGFR2IIIb is mostly expressed in endometrial epithelial cells, whereas FGFR3IIIb is found in both epithelial and stromal cells. Treatment with FGF-9 induces endometrial stromal proliferation in a dose-dependent manner. Expression of FGF-9 in stromal cells was induced by 17ß-estradiol but not by progesterone. Furthermore, the administration of 17ß-estradiol stimulates endometrial stromal cell proliferation and that can be inhibited by cotreatment with anti-FGF-9 antibody. Herein we demonstrate, for the first time, that FGF-9 is an autocrine estromedin endometrial stromal growth factor that plays roles in cyclic proliferation of uterine endometrial stroma.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
C.-W. Chien, S.-C. Lin, Y.-Y. Lai, B.-W. Lin, S.-C. Lin, J.-C. Lee, and S.-J. Tsai
Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer
Clin. Cancer Res., December 15, 2008; 14(24): 8043 - 8051.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-W. Lu, S.-C. Lin, K.-F. Chen, Y.-Y. Lai, and S.-J. Tsai
Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance
J. Biol. Chem., October 17, 2008; 283(42): 28106 - 28114.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
C. N. Perera, H. S. Spalding, S. I. Mohammed, and I. G. Camarillo
Identification of Proteins Secreted from Leptin Stimulated MCF-7 Breast Cancer Cells: A Dual Proteomic Approach
Experimental Biology and Medicine, June 1, 2008; 233(6): 708 - 720.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. E. Drummond, M. Tellbach, M. Dyson, and J. K. Findlay
Fibroblast Growth Factor-9, a Local Regulator of Ovarian Function
Endocrinology, August 1, 2007; 148(8): 3711 - 3721.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P.-C. Chuang, H. S. Sun, T.-M. Chen, and S.-J. Tsai
Prostaglandin E2 Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase C{delta} and Elk-1 Signaling
Mol. Cell. Biol., November 15, 2006; 26(22): 8281 - 8292.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
K. Inada, S. Hayashi, T. Iguchi, and T. Sato
Establishment of a primary culture model of mouse uterine and vaginal stroma for studying in vitro estrogen effects.
Experimental Biology and Medicine, March 1, 2006; 231(3): 303 - 310.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. D. Hendrix, R. Wu, R. Kuick, D. R. Schwartz, E. R. Fearon, and K. R. Cho
Fibroblast Growth Factor 9 Has Oncogenic Activity and Is a Downstream Target of Wnt Signaling in Ovarian Endometrioid Adenocarcinomas
Cancer Res., February 1, 2006; 66(3): 1354 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
T.-H. Ueng, C.-C. Hung, M.-L. Kuo, P.-K. Chan, S.-H. Hu, P.-C. Yang, and L. W. Chang
Induction of Fibroblast Growth Factor-9 and Interleukin-1{alpha} Gene Expression by Motorcycle Exhaust Particulate Extracts and Benzo(a)pyrene in Human Lung Adenocarcinoma Cells
Toxicol. Sci., October 1, 2005; 87(2): 483 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
K.-F. Chen, Y.-Y. Lai, H. S. Sun, and S.-J. Tsai
Transcriptional repression of human cad gene by hypoxia inducible factor-1{alpha}
Nucleic Acids Res., September 9, 2005; 33(16): 5190 - 5198.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. T. Marquez, K. A. Baggerly, A. P. Patterson, J. Liu, R. Broaddus, M. Frumovitz, E. N. Atkinson, D. I. Smith, L. Hartmann, D. Fishman, et al.
Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon
Clin. Cancer Res., September 1, 2005; 11(17): 6116 - 6126.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S.-J. Tsai, S.-J. Lin, Y.-M. Cheng, H.-M. Chen, and L.-Y. C. Wing
Expression and Functional Analysis of Pituitary Tumor Transforming Growth Factor-1 in Uterine Leiomyomas
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3715 - 3723.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-Y. C. Wing, H.-M. Chen, P.-C. Chuang, M.-H. Wu, and S.-J. Tsai
The Mammalian Target of Rapamycin-p70 Ribosomal S6 Kinase but Not Phosphatidylinositol 3-Kinase-Akt Signaling Is Responsible for Fibroblast Growth Factor-9-induced Cell Proliferation
J. Biol. Chem., May 20, 2005; 280(20): 19937 - 19947.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M.-H. Wu, C.-A. Wang, C.-C. Lin, L.-C. Chen, W.-C. Chang, and S.-J. Tsai
Distinct Regulation of Cyclooxygenase-2 by Interleukin-1{beta} in Normal and Endometriotic Stromal Cells
J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 286 - 295.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Agrotis, P. Kanellakis, G. Kostolias, G. Di Vitto, C. Wei, R. Hannan, G. Jennings, and A. Bobik
Proliferation of Neointimal Smooth Muscle Cells after Arterial Injury: DEPENDENCE ON INTERACTIONS BETWEEN FIBROBLAST GROWTH FACTOR RECEPTOR-2 AND FIBROBLAST GROWTH FACTOR-9
J. Biol. Chem., October 1, 2004; 279(40): 42221 - 42229.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Jin, F. Wang, X. Wu, C. Yu, Y. Luo, and W. L. McKeehan
Directionally Specific Paracrine Communication Mediated by Epithelial FGF9 to Stromal FGFR3 in Two-Compartment Premalignant Prostate Tumors
Cancer Res., July 1, 2004; 64(13): 4555 - 4562.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
V. Bourdeau, J. Deschenes, R. Metivier, Y. Nagai, D. Nguyen, N. Bretschneider, F. Gannon, J. H. White, and S. Mader
Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse
Mol. Endocrinol., June 1, 2004; 18(6): 1411 - 1427.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
B.-M. Huang, K.-Y. Hsiao, P.-C. Chuang, M.-H. Wu, H.-A. Pan, and S.-J. Tsai
Upregulation of Steroidogenic Enzymes and Ovarian 17{beta}-Estradiol in Human Granulosa-Lutein Cells by Cordyceps sinensis Mycelium
Biol Reprod, May 1, 2004; 70(5): 1358 - 1364.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. Workalemahu, M. Foerster, and C. Kroegel
Expression and synthesis of fibroblast growth factor-9 in human {gamma}{delta} T-lymphocytes. Response to isopentenyl pyrophosphate and TGF-{beta}1/IL-15
J. Leukoc. Biol., April 1, 2004; 75(4): 657 - 663.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L.-Y. C. Wing, P.-C. Chuang, M.-H. Wu, H.-M. Chen, and S.-J. Tsai
Expression and Mitogenic Effect of Fibroblast Growth Factor-9 in Human Endometriotic Implant Is Regulated by Aberrant Production of Estrogen
J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5547 - 5554.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. S. Sun, K.-Y. Hsiao, C.-C. Hsu, M.-H. Wu, and S.-J. Tsai
Transactivation of Steroidogenic Acute Regulatory Protein in Human Endometriotic Stromal Cells Is Mediated by the Prostaglandin EP2 Receptor
Endocrinology, September 1, 2003; 144(9): 3934 - 3942.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2002 by The Endocrine Society