| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
ARTICLE |
Max Planck Institut für Experimentelle Endokrinologie (S.F., S.C., K.B.), D-30625 Hannover, Germany; Department of Pathology, Columbia University (H.H.), New York, New York 10032; Institut für Anatomie und Zellbiologie, Philipps Universität Marburg (M.K.H.S.), D-35407 Marburg, Germany; Max Planck Institut für Biophysikalische Chemie (A.M.), D-37077 Gottingen, Germany; and Department of Internal Medicine, Erasmus University Medical Center (T.J.V.), NL-3000 DR Rotterdam, The Netherlands
Address all correspondence and requests for reprints to: Theo J. Visser, Ph.D., Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. E-mail: visser{at}inw3.azr.nl.
Thyroid hormones are essential for a variety of developmental and metabolic processes. Congenital hypothyroidism (CHT) results in severe defects in the development of different tissues, in particular brain. As an animal model for CHT, we studied Pax8-/- mice, which are born without a thyroid gland. We determined the expression of iodothyronine deiodinase D1 in liver and kidney, D2 in brain and pituitary, and D3 in brain, as well as serum T4, T3, and rT3 levels in Pax8-/- vs. control mice during the first 3 wk of life. In control mice, serum T4 and T3 were undetectable on the day of birth (d 0) and increased to maximum levels on d 15. In Pax8-/- mice, serum T4 and T3 remained below detection limits. Serum rT3 was high on d 0 in both groups and rapidly decreased in Pax8-/-, but not in control mice. Hepatic and renal D1 activities and mRNA levels were low on d 0 and increased in control mice roughly parallel to serum T4 and T3 levels. In Pax8-/- mice, tissue D1 activities and mRNA levels remained low. Cerebral D2 activities were low on d 0 and increased to maximum levels on d 15, which were approximately 10-fold higher in Pax8-/- than in control mice. D2 mRNA levels were higher in Pax8-/- than in control mice only on d 21. Cerebral D3 activities and mRNA levels were high on d 0 and showed a moderate decrease between d 3 and 15, with values slightly lower in Pax8-/- than in control mice. One day after the injection of 200 ng T4 or 20 ng T3/g body weight, tissue deiodinase activities and mRNA levels were at least partially restored toward control levels, with the exception of cerebral D3 activity. In conclusion, these findings show dramatic age and thyroid state-dependent changes in the expression of deiodinases in central and peripheral tissues of mice during the first 3 wk of life.
This article has been cited by other articles:
 |
|
 |
|
  J. Mittag, S. Friedrichsen, A. Strube, H. Heuer, and K. Bauer Analysis of Hypertrophic Thyrotrophs in Pituitaries of Athyroid Pax8-/- Mice Endocrinology, September 1, 2009; 150(9): 4443 - 4449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. D. Bassett, A. J. Williams, E. Murphy, A. Boyde, P. G. T. Howell, R. Swinhoe, M. Archanco, F. Flamant, J. Samarut, S. Costagliola, et al. A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism Mol. Endocrinol., February 1, 2008; 22(2): 501 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mittag, W. Oehr, H. Heuer, T. Hamalainen, B. Brachvogel, E. Poschl, and K. Bauer Expression and thyroid hormone regulation of annexins in the anterior pituitary J. Endocrinol., December 1, 2007; 195(3): 385 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alonso, C. Goodwin, X. Liao, D. Page, S. Refetoff, and R. E. Weiss Effects of Maternal Levels of Thyroid Hormone (TH) on the Hypothalamus-Pituitary-Thyroid Set Point: Studies in TH Receptor {beta} Knockout Mice Endocrinology, November 1, 2007; 148(11): 5305 - 5312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. D. Bassett, P. J. O'Shea, S. Sriskantharajah, B. Rabier, A. Boyde, P. G. T. Howell, R. E. Weiss, J.-P. Roux, L. Malaval, P. Clement-Lacroix, et al. Thyroid Hormone Excess Rather Than Thyrotropin Deficiency Induces Osteoporosis in Hyperthyroidism Mol. Endocrinol., May 1, 2007; 21(5): 1095 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mittag, E. Winterhager, K. Bauer, and R. Grummer Congenital Hypothyroid Female Pax8-Deficient Mice Are Infertile Despite Thyroid Hormone Replacement Therapy Endocrinology, February 1, 2007; 148(2): 719 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. M. van der Ven, A. Verhoef, T. van de Kuil, W. Slob, P. E. G. Leonards, T. J. Visser, T. Hamers, M. Herlin, H. Hakansson, H. Olausson, et al. A 28-Day Oral Dose Toxicity Study Enhanced to Detect Endocrine Effects of Hexabromocyclododecane in Wistar Rats Toxicol. Sci., December 1, 2006; 94(2): 281 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Forhead, K. Curtis, E. Kaptein, T. J. Visser, and A. L. Fowden Developmental Control of Iodothyronine Deiodinases by Cortisol in the Ovine Fetus and Placenta Near Term Endocrinology, December 1, 2006; 147(12): 5988 - 5994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ferretti, F. Arturi, T. Mattei, A. Scipioni, G. Tell, E. Tosi, I. Presta, R. Morisi, L. Lacroix, A. Gulino, et al. Expression, Regulation, and Function of Paired-Box Gene 8 in the Human Placenta and Placental Cancer Cell Lines Endocrinology, September 1, 2005; 146(9): 4009 - 4015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mittag, S. Friedrichsen, H. Heuer, S. Polsfuss, T. J. Visser, and K. Bauer Athyroid Pax8-/- Mice Cannot Be Rescued by the Inactivation of Thyroid Hormone Receptor {alpha}1 Endocrinology, July 1, 2005; 146(7): 3179 - 3184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Heuer, M. K. Maier, S. Iden, J. Mittag, E. C. H. Friesema, T. J. Visser, and K. Bauer The Monocarboxylate Transporter 8 Linked to Human Psychomotor Retardation Is Highly Expressed in Thyroid Hormone-Sensitive Neuron Populations Endocrinology, April 1, 2005; 146(4): 1701 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. W. J. S. Wassen, W. Klootwijk, E. Kaptein, D. J. Duncker, T. J. Visser, and G. G. J. M. Kuiper Characteristics and Thyroid State-Dependent Regulation of Iodothyronine Deiodinases in Pigs Endocrinology, September 1, 2004; 145(9): 4251 - 4263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rabeler, J. Mittag, L. Geffers, U. Ruther, M. Leitges, A. F. Parlow, T. J. Visser, and K. Bauer Generation of Thyrotropin-Releasing Hormone Receptor 1-Deficient Mice as an Animal Model of Central Hypothyroidism Mol. Endocrinol., June 1, 2004; 18(6): 1450 - 1460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Friedrichsen, S. Christ, H. Heuer, M. K. H. Schafer, A. F. Parlow, T. J. Visser, and K. Bauer Expression of Pituitary Hormones in the Pax8-/- Mouse Model of Congenital Hypothyroidism Endocrinology, March 1, 2004; 145(3): 1276 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Heuer and C. A. Mason Thyroid Hormone Induces Cerebellar Purkinje Cell Dendritic Development via the Thyroid Hormone Receptor {alpha}1 J. Neurosci., November 19, 2003; 23(33): 10604 - 10612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. O'Shea, C. B. Harvey, H. Suzuki, M. Kaneshige, K. Kaneshige, S.-Y. Cheng, and G. R. Williams A Thyrotoxic Skeletal Phenotype of Advanced Bone Formation in Mice with Resistance to Thyroid Hormone Mol. Endocrinol., July 1, 2003; 17(7): 1410 - 1424. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
