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Angiotensin-(1–7): A Novel Peptide in the Ovary

Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, Brazil

Address all correspondence and requests for reprints to: Dr. Adelina Martha dos Reis, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Antonio Carlos 6627, CEP 31270–901, Belo Horizonte MG, Brazil. E-mail: adelina{at}icb.ufmg.br.

The present study was undertaken to investigate the presence of angiotensin-(1–7) [Ang-(1–7)] in the ovary and a possible role for it. Cycling female rats were killed in each phase of the estrous cycle, and ovarian Ang II and Ang-(1–7) were separated by HPLC and measured by RIA. The mean levels of Ang-(1–7) in proestrus and estrus were significantly higher than those in metestrus and diestrus (P < 0.05). Ang-(1–7) was also significantly higher in equine chorionic gonadotropin (eCG)-treated immature rats. Ang-(1–7) induced a significant increase in estradiol and progesterone production (P < 0.05) in the ovary of immature rats (24–25 d old) pretreated with eCG and perfused in a closed circuit system. This effect was blocked by A-779, a specific Ang-(1–7) antagonist (P < 0.05). The present data demonstrate the presence and physiological role of a novel renin-Ang system peptide in the ovary. The higher level of Ang-(1–7) in proestrus and estrus as well as in eCG-treated rats suggests the involvement of this renin-Ang system peptide in pre- and postovulatory events.

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