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Endocrinology, doi:10.1210/en.2003-0009
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Endocrinology Vol. 144, No. 8 3338-3343
Copyright © 2003 by The Endocrine Society

Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7)

Liomar A. A. Neves, Aleck F. Williams, David B. Averill, Carlos M. Ferrario, Michael P. Walkup and K. Bridget Brosnihan

The Hypertension and Vascular Disease Center (L.A.A.N., A.F.W., D.B.A., C.M.F., K.B.B.), and Public Health Sciences (M.P.W.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1932

Address all correspondence and requests for reprints to: K. Bridget Brosnihan, Ph.D., The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1032. E-mail: bbrosnih{at}wfubmc.edu.

The vasoactive effect of angiotensin (Ang)-(1–7) in mesenteric resistance arteries together with its plasma and kidney concentration and urinary excretion was assessed in pregnant and virgin rats. Mesenteric arteries (230–290 µm) were mounted in a pressurized myograph system and Ang-(1–7) concentration-dependent response curves (10-10–10-5 M) were determined in arteries preconstricted with endothelin-1 (10-7 M). The Ang-(1–7) response was investigated in vessels with and without pretreatment with the Ang-(1–7) antagonist [D-[Ala7]-Ang-(1–7)] (10-7 M). Ang-(1–7) caused a significantly enhanced, concentration-dependent dilation of mesenteric vessels (EC50 = 2.7 nM) from pregnant compared with virgin female rats. D-[Ala7]-Ang-(1–7) eliminated the vasodilator effect of Ang-(1–7). There was no significant change in plasma concentration of Ang-(1–7) in pregnant animals. On the other hand, 24 h urinary excretion and kidney concentration of Ang-(1–7) were significantly higher in pregnant animals. The increased mesenteric dilation to Ang-(1–7) with enhanced kidney concentration and 24 h urinary excretion rate of Ang-(1–7) suggests an important role for this peptide in cardiovascular regulation during pregnancy.






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Copyright © 2003 by The Endocrine Society