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Endocrinology, doi:10.1210/en.2003-1222
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Endocrinology Vol. 145, No. 1 36-38
Copyright © 2004 by The Endocrine Society

BRIEF COMMUNICATION

Possible Involvement of Ryanodine Receptor-Mediated Intracellular Calcium Release in the Effect of Corticotropin-Releasing Factor on Adrenocorticotropin Secretion

Etsuko Yamamori, Yasumasa Iwasaki, Yutaka Oki, Masanori Yoshida, Masato Asai, Machiko Kambayashii, Yutaka Oiso and Nobuo Nakashima

Departments of Medicine (E.Y., M.Y., M.A., Y.O.) and Clinical Pathophysiology (Y.I., M.K., N.N.), Nagoya University Graduate School of Medicine and Hospital, Nagoya 466-8550, Japan; and Department of Medicine II (Y.O.), Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan

Abstract

We examined the role of intracellular calcium release in the regulation of CRH-induced ACTH secretion using the AtT20 corticotroph cell line. We found that ruthenium red, an inhibitor of ryanodine receptor, substantially diminished the secretory response, whereas Xestospongin C, an inositol 1,4,5-triphosphate receptor antagonist, had no effect. Expression of two ryanodine receptor subtypes (RyR1 and RyR3) was confirmed by RT-PCR. We also found that caffeine, a ryanodine receptor agonist, significantly stimulated, whereas thapsigargin, which causes depletion of intracellular calcium store, markedly diminished, the ACTH release. These results suggest that ryanodine receptor-mediated calcium-induced calcium release is involved in the regulation of CRH-induced ACTH release.




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S. M. Soares, M. Thompson, and E. N. Chini
Role of the Second-Messenger Cyclic-Adenosine 5'-Diphosphate-Ribose on Adrenocorticotropin Secretion from Pituitary Cells
Endocrinology, May 1, 2005; 146(5): 2186 - 2192.
[Abstract] [Full Text] [PDF]


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