| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
1 Knockout Mice Reveals an Interplay between Thyroid Hormone Receptor Isoforms
Instituto de Investigaciones Biomédicas Alberto Sols (B.M., J.M., J.B.), Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, 28029 Madrid, Spain;. Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology (T.S.S.), University of California, San Francisco, California 94143-2280; and Laboratory of Developmental Biology (B.V.), CMB, Karolinska Institute, Stockholm S-17177, Sweden
Address all correspondence and requests for reprints to: Dr. Juan Bernal, Instituto de Investigaciones Biomédicas, Arturo Duperier 4, 28029 Madrid, Spain. E-mail: jbernal{at}iib.uam.es.
Although the effects of thyroid hormones on the development of neurons and oligodendrocytes are well documented, less is known about the hormonal effects on astrocytes. Our analyses of cerebellar slices from 2-month-old T3 receptor protein (TR)
1-deficient mice show that mature astrocytes, Golgi epithelial cells, and their Bergmann processes had strongly reduced glial fibrillary acidic protein (GFAP) and nestin immunoreactivity, in contrast to wild-type mice. Furthermore, the Bergmann processes exhibited an irregular GFAP staining. A similar expression of nestin and GFAP was observed in 11-d-old (P11) mutant pups. Surprisingly, however, hypothyroidism normalized the appearance of these markers in the P11 mutants, suggesting that liganded TRß is detrimental to astroglial cell differentiation in the absence of TR1. To test this hypothesis, hypothyroid mice were treated from birth until P11 with the TRß-selective ligand GC-1. This treatment was devastating in the TR1-/- mice, causing little if any nestin or GFAP immunoreactivity, whereas the wild-type mice were normal. The results thus indicate an important interplay between thyroid hormone receptor isoforms in astroglial cell maturation.
This article has been cited by other articles:
 |
|
 |
|
  J. Manzano, M. Cuadrado, B. Morte, and J. Bernal Influence of Thyroid Hormone and Thyroid Hormone Receptors in the Generation of Cerebellar {gamma}-Aminobutyric Acid-Ergic Interneurons from Precursor Cells Endocrinology, December 1, 2007; 148(12): 5746 - 5751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Quignodon, C. Grijota-Martinez, E. Compe, R. Guyot, N. Allioli, D. Laperriere, R. Walker, P. Meltzer, S. Mader, J. Samarut, et al. A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum J. Mol. Endocrinol., July 1, 2007; 39(1): 17 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M Villicev, F. R S Freitas, M. S Aoki, C. Taffarel, T. S Scanlan, A. S Moriscot, M. O Ribeiro, A. C Bianco, and C. H A Gouveia Thyroid hormone receptor {beta}-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats J. Endocrinol., April 1, 2007; 193(1): 21 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Columbano, M. Pibiri, M. Deidda, C. Cossu, T. S. Scanlan, G. Chiellini, S. Muntoni, and G. M. Ledda-Columbano The Thyroid Hormone Receptor-{beta} Agonist GC-1 Induces Cell Proliferation in Rat Liver and Pancreas Endocrinology, July 1, 2006; 147(7): 3211 - 3218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Trentin Thyroid hormone and astrocyte morphogenesis. J. Endocrinol., May 1, 2006; 189(2): 189 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Zoeller, R. Bansal, and C. Parris Bisphenol-A, an Environmental Contaminant that Acts as a Thyroid Hormone Receptor Antagonist in Vitro, Increases Serum Thyroxine, and Alters RC3/Neurogranin Expression in the Developing Rat Brain Endocrinology, February 1, 2005; 146(2): 607 - 612. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
