This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wang, S. H. Articles by Baker, J. R. Search for Related Content PubMed PubMed Citation Articles by Wang, S. H. Articles by Baker, J. R., Jr.

Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0648

Address all correspondence and requests for reprints to: Dr. James R. Baker, Jr., Department of Medicine, University of Michigan Medical Center, 9220 MSRB III, Ann Arbor Michigan 48109-0648. E-mail: jbakerjr{at}umich.edu.

The role of TNF-related apoptosis-inducing ligand (TRAIL) in autoimmune thyroiditis is unclear. We used experimental autoimmune thyroiditis to clarify the contribution of TRAIL to the development of autoimmune thyroiditis. CBA/J mice were immunized with murine thyroglobulin, and spleen cells from these mice were subsequently injected into irradiated recipient CBA/J mice. One week later, the recipient mice were treated with recombinant TRAIL or a control protein. Compared with control animals, TRAIL-treated mice developed a milder form of the disease with a significant decrease in mononuclear cell infiltration in the thyroid and less thyroid follicular destruction. Furthermore, the number of apoptotic thyrocytes and also thyroglobulin-specific T helper-1 cell responses in TRAIL-treated mice was lower than that in the control animals. This study suggests that exogenous TRAIL suppresses the development of autoimmune thyroiditis via altering the function of cells involved in the immune response. These findings may contribute toward a novel treatment autoimmune thyroiditis.

This article has been cited by other articles:

				S. H. Wang, G.-H. Chen, Y. Fan, M. Van Antwerp, and J. R. Baker Jr. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis by the Expansion of CD4+CD25+ Regulatory T Cells Endocrinology, April 1, 2009; 150(4): 2000 - 2007. [Abstract] [Full Text] [PDF]

				T. S. Griffith, H. Kazama, R. L. VanOosten, J. K. Earle Jr., J. M. Herndon, D. R. Green, and T. A. Ferguson Apoptotic Cells Induce Tolerance by Generating Helpless CD8+ T Cells That Produce TRAIL J. Immunol., March 1, 2007; 178(5): 2679 - 2687. [Abstract] [Full Text] [PDF]